Futoshi Matsui

Long-term outcome of ovotesticular disorder of sex development: A single center experience

Objectives:  To describe the clinical features of children with ovotesticular disorder of sex development (DSD) and to review cases of ovotesticular DSD in Japan.

Bladder Function After Total Urogenital Mobilization for Persistent Cloaca

PURPOSE Total urogenital mobilization has achieved widespread use because it avoids surgical complications of vaginal reconstruction. We used urodynamic studies to assess bladder function and urological outcomes after definitive repair by total urogenital mobilization. MATERIALS AND METHODS We identified 27 girls diagnosed with persistent cloaca between 1991 and 2008. We retrospectively reviewed the records of 11 patients (median age 14 months) who underwent reconstruction of the cloaca by total urogenital mobilization. Urinary continence was assessed in 7 patients older than 4 years. Urodynamic studies were performed postoperatively in 7 patients. Median followup was 72 months. RESULTS Rate of surgical complications was 9%. Urinary continence was achieved in 6 patients (86%), while 1 patient (14%) remained incontinent. Of the continent patients 3 (43%) voided spontaneously and 3 (43%) required clean intermittent catheterization. Urodynamic studies showed detrusor underactivity or acontractile detrusor in all patients during the voiding phase. Bladder compliance was normal in 6 patients (86%) and poor in 1 (14%). Detrusor overactivity was seen in 5 patients (71%) but resolved on followup in 2 (40%). Rate of continence was higher in the absence of detrusor overactivity (1 of 1 patient vs 2 of 3 with detrusor overactivity). CONCLUSIONS Most patients with persistent cloaca can achieve urinary continence after total urogenital mobilization. Two-thirds of patients display bladder dysfunction after the procedure. Detrusor overactivity can resolve with development of the bladder but persistent detrusor overactivity might delay the achievement of mechanisms of urinary continence.

Late Recurrence of Symptomatic Hydronephrosis in Patients With Prenatally Detected Hydronephrosis and Spontaneous Improvement

PURPOSE Most prenatal hydronephrosis improves or resolves spontaneously with conservative treatment. However, late recurrence of prenatal hydronephrosis sometimes develops after improvement. To define the need for continuous observation after improvement of hydronephrosis, long-term followup was carried out in children with prenatally diagnosed hydronephrosis. MATERIALS AND METHODS We retrospectively evaluated 344 cases initially presenting between July 1991 and June 2004 with prenatally detected hydronephrosis that persisted postnatally. Subjects underwent periodic assessment of hydronephrosis using ultrasonography and diuretic renography. Indications for surgery were associated symptoms, enlarged renal pelvis, worsening hydronephrosis on sequential ultrasonography and decrease in differential renal function greater than 5%. Mean duration of followup was 10.1 years. RESULTS Of the 394 kidneys followed nonoperatively 4 (1%) displayed worsened hydronephrosis after spontaneous improvement. Initial grade of hydronephrosis was grade I in 1 patient, grade II in 1, grade III in 1 and grade IV in 1. On serial ultrasonographic followup hydronephrosis worsened to grade IV in 3 kidneys and to grade III in 1 kidney. Mean patient age at worsening of hydronephrosis was 40 months (range 22 to 60). All 4 patients presented with clinical symptoms. All patients who underwent pyeloplasty displayed no symptoms, and had improved hydronephrosis after pyeloplasty. CONCLUSIONS Prenatally detected hydronephrosis can worsen after spontaneous postnatal improvement. Long-term followup is not required after improvement of prenatal hydronephrosis. However, pediatric urologists need to tell the parents that the child should undergo ultrasonography if clinical symptoms develop.

Delayed decrease in differential renal function after successful pyeloplasty in children with unilateral antenatally detected hydronephrosis

Aim:  The aim of this study was to evaluate functional outcome of congenital hydronephrotic kidney.

Urological emergency in neonates with congenital hydronephrosis

Objective:  It is well described that unilateral pelviureteric junction obstruction (PUJO) is a benign condition, because the dilatation resolves spontaneously and the function does not decrease in most of the kidneys. However, there is exceptional PUJO that requires emergent treatment in neonatal periods. The aim of this article is to report the urological emergency and management in neonates with PUJO.

Measurement‐specific bioavailable testosterone using concanavalin A precipitation: Comparison of calculated and assayed bioavailable testosterone

Objective:  To assess the value of calculated bioavailable testosterone (cBT) and assayed BT (aBT) for the diagnosis of late‐onset hypogonadism (LOH) in middle‐aged and elderly subjects.

Acquired Undescended Testes in Boys With Hypospadias

PURPOSE We determined the incidence of acquired undescended testes in boys with hypospadias. MATERIALS AND METHODS We retrospectively reviewed the records of 566 boys with hypospadias who were referred to our outpatient clinic between January 2000 and September 2009. Acquired undescended testes were defined as testes that were documented at the bottom of the scrotum at least once after birth by the pediatric urologist at our institution but were subsequently documented to have moved from a satisfactory scrotal position by the same pediatric urologist or an equally experienced pediatric urologist. However, this definition did not include undescended testes after inguinoscrotal surgery. We excluded boys with gender development disorders with testicular dysgenesis, those who underwent bilateral inguinoscrotal surgery and those without congenital cryptorchidism who were followed less than 3 months. RESULTS Of the 566 boys with hypospadias 100 met study exclusion criteria. Of the 466 boys included in analysis 29 (6.2%) had congenital cryptorchidism and 15 (3.2%) had acquired undescended testes. Urethroplasty was performed in 413 boys, including 91 with distal, 132 with mid and 181 with proximal hypospadias. The incidence of congenital cryptorchidism and acquired undescended testes in boys with proximal hypospadias was significantly higher than that in boys with other types of hypospadias (p = 0.03 and 0.001, respectively). CONCLUSIONS Boys with proximal hypospadias are at a higher risk for acquired undescended testes than those with other mild types of hypospadias. Thus, testicular location should be monitored regularly until after puberty.

Positioning the instillation of contrast at the ureteral orifice cystography can be useful to predict postoperative contralateral reflux in children with unilateral vesicoureteral reflux

The aim of the present study was to evaluate the usefulness of positioning the instillation of contrast at the ureteral orifice (PIC) cystography in prediction of postoperative contralateral reflux in patients with unilateral vesicoureteral reflux (VUR) undergoing ureteral reimplantation. Between January 2007 and March 2009, 34 children (20 boys and 14 girls) had antireflux surgery for unilateral primary VUR. This was diagnosed by conventional fluoroscopic voiding cystourethrography (VCUG) in all patients. After induction of general anesthesia, PIC cystography was carried out immediately before ureteral reimplantation by instilling contrast material at the ureteral orifice. Patients with positive PIC cystogram on the contralateral side underwent bilateral ureteral reimplantation via the Cohen technique. VCUG was repeated at 6–12 months postoperatively. Of the 34 patients, 16 (47%) showed VUR on the contralateral side on PIC cystography and underwent bilateral reimplantation. The remaining 18 patients (53%) with negative PIC cystogram underwent unilateral reimplantation, and no VUR was detected by postoperative VCUG in all ureters. None of the 34 patients had surgical complications or recurrent urinary tract infections. In conclusion, PIC cystography represents a useful tool to predict new onset contralateral VUR in patients with unilateral VUR on conventional VCUG.

Prepuce-Sparing hypospadias repair with tubularized incised plate urethroplasty

Objectives:  Modifications in surgical methods of hypospadias repair have been influenced by social considerations. Most Japanese parents wish their children to retain their foreskin during hypospadias repair. We report on short‐term results of foreskin reconstruction associated with hypospadias repair.

Surgical treatment for ureterocele with special reference to lower urinary tract reconstruction

Objectives:  We reviewed the results of surgical treatment for children with ureterocele, especially addressing the importance of the lower urinary tract reconstruction.