G. A. Harrison

An Investigation of Sclerema Neonatorum; with Special Reference to the Chemistry of the Subcutaneous Tissues: (Part II.).

CIIEMICAL INNVESTIGATION OF SUBCUTANEOUS TISSUES. A few preliminary determinations only were nmade by McNee in Cases I. and IT. These will be given first. As a result of the experience gained in these two eases, a definite plan of campaign was outlined for the investigation of Cases III. and IV. Case V. recovered spontaneously and no biopsy was made. A. Cases I. a-1(1 II. and Controls. The fat was melted otut of a imiassof subcutaneous fat, and dried. TIhe melting point of this separated fat was taken by the capillary method; and the, iodine value was determined by Hubls method.

THE STRENGTH OF INSULIN PREPARATIONS: A COMPARISON BETWEEN LABORATORY AND CLINICAL MEASUREMENTS.

lfayo, W. J.: Journ. Amer. Med. Assoc., 1924, lxxxiii, 815. aegeli, 0.: Blutkrankheiten und Bluddiagnostib 1923. Osman, A. A.: Guys Hosp. Reports, 1922, lxXi, 1i. Parisot, J., et Heully, L.: Bull. et mem. Soc. mid. des hdp. do Paris, 1912, 3e sir., xxxiv, 527. Poynton, F. J., Thursfield, H., and Paterson, D.: Brit. Journ. Child. Die., 1922, xix, 143. Ricaldo et Albo: Bull. et m6m. Soc. m6d. des h6p. de Paris, 1924, 3e air., xlviii, 493. Richards, O., and Day, H. B.: Trans. Soc. Trop. Med. and Hyg., 1911-12, v, 333. Rogers, L.: Fevers in the Tropics, p. 8, 1919. 8till, G. F.: Practitioner, 1904, lxxiii, 101. 8utherland, G. A., and Williamson, B.: Lancet 1925, 1, 323. Talbot F. B. and Lyon, A. B.: Amner. Journ. bis. Child 1918, xvi, 156. Thomson, Jobn: The Clinical Study and Treatment ;1 Sick Children, 1925, p. 425. Thursfield, H.: Diseases of Children (Garrod, Batten, and Thursfield), 1913, pp. 527, 534. Tidy, H. L.: Quart. .ourn. Med. Oxford, 1923.24, xvii, 210. Vincent, B. Boston Med. and gur . Journ. 1925, cxciii, 191. Waugh, H. R., and MacIntosh, D. ., Arch. mt. Med., 1924, xxxiii,-599. Weber F P.: Polycythaemia, Erythrocytosis, and Erythraemia (Vaquezs Osier Disease), 1921, p. 71. Well, E.-: Bull. et menm. Soc. mid. des h6p. de Paris, 1919, 3. sir., xliii, 111 Thitcher, B. R.: Proc. New York Path. Soc., 1925, xxv, 25. Willmore, J. G., and Mackenzie Douglas: BRITISH MEDICAL JouRNA, 1925, i, 16. NWyl.lie, W. G.: Proc. Roy. Soc. Med., 1925, xix (Dis. Child. Sect.), 5.

THE PATHOGENESIS OF XANTHOMATOSIS, WITH REPORT OF A CASE

A. WHITFIELD, M.D.LOND., F.R.C.P., Professor of Dermatology, Kings College ; and Physician-in-Charge, Skin Department, Kings College Hospital. CONSIDERABLE interest has been evinced in this comparatively rare disease during recent years, largely we believe on account of the introduction into clinical medicine of relatively simple methods of blood analysis. The following case has been fairly thoroughly investigated on modern lines, and is of especial value in that it would appear to occupy an intermediate position between the types with frank diabetes and the varieties without any glycosuria. Mrs. W—, aged 62 years. Small lumps were noticed on both elbows twelve years ago, at the end of the climacteric. The patient states that her arms became excessively freckled at the same time, and that between the ages of 45 and 55 she gained 3 st. in weight. She was seen by one of us (A. W.) in 1913, and exhibited before the Dermatological Section of the Royal Society of Medicine (Whitfield p)). The nodules on the left elbow disappeared after a single application of carbon dioxide snow in October, 1913. Those on the right elbow were treated with X-rays—three or four applications with intervals of three weeks—later in 1913 without effect. In 1915 or 1916 one of the nodules on the right elbow was frozen. The patient did not return for treatment until 1922 when she noted that the elbows were a little tender on rising from bed. In May this year two more nodules were successfully treated with carbon dioxide snow. In August a large nodule was excised for histological and

On the Clinical Value of Blood Analyses in Nephritis in Childhood.

The following analyses (Tables I and II) confirm the work of previous investigators. The series is, however, fairly extensive, arid serves as the basis of a short discussion on the value of such estimations in clinical medicine. tTrea was estimated by the urease method, using 3 c.cm. of blood. Cholesterol and plasma proteins were determined colorimetrically, according to the techniques of Myers and Wardell( 2), and of W11 (3) respectively. The tables are self-explanatory. TABLE I. BLOOD CHOLESTEROL AND UREA IN NEPHRITIS.