G. A. Kuznetsova

Acyl Iodides in Organic Synthesis: IX. Cleavage of the Si-O-C and Si-O-Si Moieties

Reactions of acyl iodides RCOI (R = Me, Ph) with organosilicon compounds involve cleavage of the Si-O-C and Si-O-Si fragments. Acetyl iodide reacts with alkyl(alkoxy)silanes with evolution of heat, and cleavage of the Si-O bond results in the formation of oligo-or polysiloxanes, alkyl iodides, and alkyl acetates. 1,3-Diacetoxytetramethyldisiloxane is formed in the reaction of acetyl iodide with dimethoxy(dimethyl)silane. Acyl iodides readily react with 1-ethoxysilatrane to give 1-acyloxysilatranes as a result of cleavage of the C-O bond. The reaction of acetyl iodide with hexaethyldisiloxane yields triethylsilyl acetate and triethyliodosilane, while in the reaction with octamethyltrisiloxane iodo(trimethyl)silane and dimethyl(trimethylsiloxy)silyl acetate are obtained.

Complexes of triethanolamine with aroxyacetic acids and their metal salts as a new class of biologically active compounds

A series of complexes of triethanolamine with metal salts of aroxyacetic acids has been prepared. The complexes are perspective biologically active compounds for search for new immunomodulating, antistress, anti-inflammatory and other types of agents. The structure and acid-base properties of these compounds were studied by NMR and IR spectroscopy and potentiometric titration.

New biologically active arylchalcogenylacetates based on triethanolamine N -oxide

New potentially pharmacologically active tris(2-hydroxyethyl)hydroxyammonium salts were synthesized by the reaction of triethanolamine N-oxide with biologically active acetic acid derivatives RYCH2CO2H (R = Ar, 3-indolyl; Y = O, S, SO2).

Synthesis of triethanolamine complexes with zinc organylheteroacetates, promising biologically active compounds

A series of two- and three-component complexes was synthesized of triethanolamine with zinc salts of organylheteroacetic acids, promising biologically active compounds for the search for immunomodulating, antistressor, antitumor, etc. drugs.

Thermodynamic properties of 1,3-dimethylsilatrane and 1-(2-cyanoethyl)silatrane

The heat capacities of 1,3-dimethylsilatrane and 1-(2-cyanoethyl)silatrane were measured, and their thermodynamic functions were calculated. In the intervals 12–205 and 215–315 K, the heat capacity of 1,3-dimethylsilatrane smoothly varies with temperature. A reproducible thermal effect is observed at ∼315 K, and a G-type transition, in the range 205–215 K. 1-(2-Cyanoethyl)silatrane shows no anomalies in the examined temperature range. Above 260 K, the rate of the growth of the heat capacity with temperature increases.

Oxatrane is a parent compound of a new atrane family: Crystal and molecular structure of triethanolamine N-oxide

⎯ (previously O=NR3 or O → NR3) continue to attract interest of synthetic, theoretical, and applied chemists. They are already used in cosmetics, as bio medical agents, and as oxidants in a number of organic reactions (catalytic epoxidation and dihydroxylation of alkenes, catalytic oxidation of alcohols, etc.) [1, 2]. The most general method of their synthesis is the oxi dation of tertiary amines with hydrogen peroxide, per oxy acids, dioxiranes, and oxaazapyridines [1].

Direct synthesis of 1-organylsilatranes from organyltrichlorosilanes and tris(2-hydroxyethyl)amine

A direct method of synthesis of 1-organylsilatranes by the reaction of organyltrichlorosilanes with tris(2-hydroxyethyl)amine was developed. 1-Organylsilatranes RSi(OCH2CH2)3N with R = Me, Et, Ph, ClCH2, ICH2, Cl(CH2)3 were prepared by this method in up to 72% yield.

Crystal and molecular structure of 1-(iodmethyl)- and 1-(iodpropyl)silatranes

The crystal and molecular structures of 1-(iodmethyl)silatrane and 1-(iodpropyl)silatrane are determined by X-ray diffraction. The effect of the iodine heteroatom upon silatrane moieties of the molecules through oneand three-carbon chains is studied based on the geometric characteristics of the molecules and the analysis of their packings.

Fungistatic polyphenylmethylsiloxane resin prepared from the phenyltrichlorosilane production bottoms

Polyphenylmethylsiloxane resin exhibiting a strong fungistatic effect was prepared by hydrolysis of phenyltrichlorosilane production bottoms with addition of phenyltrichlorosilane and methyltrichlorosilane.

Electronic and conformational effects in 2-hydro-1,3-dioxa-6-aza-2-silacyclooctanes

Conclusions1.The degree of the transannular interaction N → Si in 2-hydro-l,3-dioxa-6-aza-2-silacyclooctanes was evaluated from the dependence of the frequency of the band of the stretching vibration of the Si-H bond on the polarity of the solvent and the temperature.2.The presence of two bands of the stretching vibration of the Si-H bond in the IR spectra of the solutions of derivatives of 2-hydro-l,3-dioxa-6-aza-2-silacyclooctanes was caused by the conformational isomerism of the (H)SiOC fragment.