G. A. Mokrushina

Nucleophilic substitution in 2-nitro-3-halopyridines

Nucleophilic substitution occurs in the 2 or 3 position in 2-nitro-3-halopyridines depending on the nature of the halogen and the substituting agent. A series of new 2,3-substituted pyridines were obtained as a result of the reactions.

Syntheses of bisheterocycles from 2-hydrazino-3-aminopyridine

Abstract2-Hydrazino-3-aminopyridine reacts with carbon disulfide in an alkaline medium to give 1H-3-aminoimidazo[4,5-b]pyridine-2-thione and in a neutral medium to give 8-amino-3-thio-sym-triazolino[4,3-a]pyridine. The reaction of 2-α-methylhydrazino-3-aminopyridine with carbon disulfide leads to anhydro-1-methyl-3-mercapto-8-amino-sym-triazolo[4,3-a]pyridinium betaine.

Synthesis of 2-hydrazinobenzimidazoles and their antiinfluenza activity

New antiviral agents are being sought in various classes of compounds, including derivatives of benzimidazole. The present study offers data on the antiinfluenza activity and synthesis of the 2-hydrazine derivatives of benzlmidazole which have various substituents both on the nitrogen atom N(1) (hydrogen, methyl, ethyl, benzyl, oxyethyl, and chlorine-compounds I-XV)) and 1,5,6-trlmethyl-2-hydrazinobenzimidazole (XVI).

Benzimidazole derivatives with zwitterion structures

Abstract2-Pyridinium and β- and γ-picolinium-5,6-dinitrobenzimidazole betaines were obtained by reaction of 5,6-dinitro-2-chlorobenzimidazole with pyridine and β- and γ-picolines.

Synthesis and biological activity of benzimidazole-5-carboxamides

We have previously reported [4] that in 2-hydrazinobenzimidazoles, the greatest antiviral activity is shown by compounds bearing a carboxy or ethoxycarbonyl group in the 5-position. Continuing work on the synthesis and examination of the antiviral activity of benzimidazoles, we have synthesized some benzimidazole-5-carboxamides substituted in the 2-position with chloro-, hydrazine-, and isopropylidene (and isobutylidene)hydrazino-groups (III-XIX).

SYNTHESIS AND PROPERTIES OF PYRIDINE SULFAMIDES AND S-TRIAZOLO(4,3-A)PYRIDINES

Durch Uberfuhrung von 2-Nitro-3-aminopyridin (I) in 2-Chlorpyridin-3-sulfonsaure- Chlorid (II) durch Diazotieren von (I), durch Ersatz der Diazoniumgruppe durch die Sulfochlorid-Gruppe sowie Austausch der Nitrogruppe gegen ein Chloratom (Kotovskaya, S.K.

Synthesis and properties of 3-thiono derivatives of pyrido[2,3-e]-asym-triazine

Abstract2-Amino-3-hydrazinopyridine reacts with carbon disulfide to give 1,2,3,4-tetrahydropyrido[2,3-e]-asym-triazine-3-thione. The methylthio derivative obtained from it is oxidized to the sulfone, which undergoes exchange of the methylsulfonyl group for an amine residue in the cold. The methylthio derivative undergoes this sort of reaction only on heating, whereas in the cold it reacts with amines to give adducts that are unstable in solution and on heating.