G. Anner

Über Synthesen in der Aldosteron-Reihe I. Totalsynthese des racemischen Aldosterons

d,l-Aldosterone (XXIV) has been prepared by total synthesis, involving more than 20 new steps, from the tricyclic compound I.

Ein neues Verfahren zur Herstellung von 19-Norsteroiden

The new methods for the production of 19-norsteroids described involve the conversion of 5α-halogen-6β-hydroxy-steroids into the corresponding 5α-halogen-6β:19-ethers either with lead tetraacetate or by the hypoiodite reaction8,10. The 6β:19-oxygen bridge is then opened reductively either directly or after oxidation of the 6β:19-ethers to lactones or preferably after introduction of a Δ4,6-3-oxo grouping. Acylolytic cleavage of the Δ4-3-oxo-6β:19-ethers followed by alkaline hydrolysis gives Δ4,6-3-oxo-19-hydroxy-steroids. The 19-hydroxycompounds formed are easily converted into 19-norsteroids by known methods.

Über eine neue Synthese von 18-Hydroxy- und 18-Oxo-progesteron

18-Hydroxyprogesterone (VII) and the corresponding 18-aldehyde (IX), hitherto only accessible with difficulty from natural 18-substituted steroids, have been synthesized starting from progesterone.