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Dive into the research topics where G. Borroni is active.

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Featured researches published by G. Borroni.


Journal of Hepatology | 1994

Vasopressin release and water metabolism in patients with cirrhosis

Francesco Salerno; Alberto DelBo; Alessandra Maggi; Monica Marabini; Maria Maffi; G. Borroni; Pamela Moser

Water retention is a complication in many patients with cirrhosis, usually attributed to excessive release of arginine vasopressin. To investigate the responsiveness of arginine vasopressin to osmotic and non-osmotic stimuli and its relationship to free water excretion, we studied 19 patients with cirrhosis under three different conditions: 45 min with legs raised to 60 degrees, to expand the central blood volume; infusion of 1000 ml of 0.45% saline solution to reduce plasma osmolality; and rapid injection of 50 ml of 2 M NaCl to increase plasma osmolality. Both expansion of central blood volume and decrease of plasma osmolality significantly reduced plasma vasopressin levels (from 2.1 +/- 0.6 to 1.39 +/- 0.3 pg/ml, p < 0.04; and from 1.09 +/- 0.25 to 0.41 +/- 0.13 pg/ml, p < 0.0001). The changes in free water excretion differentiated two subgroups of patients during each test: excretors and non-excretors. In the excretors, increased free water excretion was associated with suppressed vasopressin levels (below 0.5 pg/ml) and normal renal function. In the non-excretors, inability to improve free water excretion was associated with high vasopressin levels or with reduced distal delivery of the glomerular filtrate, except in some cases where vasopressin levels had fallen below 0.5 pg/ml and renal function was normal. For these cases the presence of other vasopressin-independent antidiuretic mechanisms is conceivable. The injection of hypertonic saline solution caused significant rises in plasma osmolality (from 287 +/- 1.9 to 292 +/- 1.6 mmol/kg, p < 0.05) and in plasma vasopressin levels (from 1.13 +/- 0.29 to 2.86 +/- 0.52 pg/ml, p < 0.05). These results suggest that vasopressin release in patients with cirrhosis is normally responsive to osmotic and non-osmotic stimuli, although our results show a lower theoretical osmolar threshold for suppression of vasopressin release in non-excretors than in excretors (276 vs 284 mmol/kg).


Digestive and Liver Disease | 2011

P.1.41: REDUCED RENAL FUNCTION IS ASSOCIATED WITH ANEMIA DURING TREATMENT WITH PEGINTERFERON/RIBAVIRIN IN ELDERLY CHRONIC HEPATITIS C PATIENTS

R. Ceriani; M. Andreoletti; G. Borroni; Aurora Bortoli; M.A. Casiraghi; M. Cazzaniga; P. Guerzoni; G. Mandelli; B. Omazzi; M.G.L. Pich; Alberto Prada; N. Terreni; G. Spinzi

REDUCED RENAL FUNCTION IS ASSOCIATEDWITH ANEMIA DURING TREATMENT WITH PEGINTERFERON/RIBAVIRIN IN ELDERLY CHRONIC HEPATITIS C PATIENTS R. Ceriani∗ ,1, M. Andreoletti 2 , G. Borroni 3, A. Bortoli 4 , M. Casiraghi 5, M. Cazzaniga6 , P. Guerzoni7 , G. Mandelli 8 , B. Omazzi 4, M.G. Pich1, A. Prada4, N. Terreni 8, G. Spinzi 8 1Irccs Istituto Clinico Humanitas, Rozzano (MI), Italy; 2Ospedale A Manzoni, Lecco, Italy; 3Asl Milano 1, Milano, Italy; 4Ospedale G Salvini, Rho (MI), Italy; 5Ospedale Civile, Legnano, Italy; 6Irccs Policlinico S. Donato, S Donato Milanese (MI), Italy; 7Ospedale Varese, Varese, Italy; 8Ospedale Valduce, Como, Italy


The American Journal of Gastroenterology | 1993

Survival and prognostic factors of cirrhotic patients with ascites : a study of 134 outpatients

Francesco Salerno; G. Borroni; Pamela Moser; Badalamenti S; Cassarà L; Alessandra Maggi; Fusini M; Bruno Cesana


Digestive and Liver Disease | 2000

Clinical relevance of hyponatraemia for the hospital outcome of cirrhotic patients

G. Borroni; Alessandra Maggi; A. Sangiovanni; M. Cazzaniga; Francesco Salerno


Hepatology | 1992

Renal effects in cirrhotic patients with avid sodium retention of atrial natriuretic factor injection during norepinephrine infusion

Salvatore Badalamenti; G. Borroni; Elettra Lorenzano; Pierluigi Incerti; Francesco Salerno


Hepatology | 1996

Long-term administration of Isosorbide-5-mononitrate does not impair renal function in cirrhotic patients

Francesco Salerno; G. Borroni; Elettra Lorenzano; Daniela Solenghi; M. Cazzaniga; Franco Bissoli; Roberto Ceriani; Roberto DeFranchis


Journal of Hepatology | 2004

463 Comparison of usefulness and accuracy of simple noninvasive models as predictors of cirrhosis in chronic hepatitis C (CHC)

G. Borroni; M. Cazzaniga; Roberto Ceriani; M.A. Tommasini; C. Maltempo; C. Felline; A. Maggi


Journal of Hepatology | 2008

723 ARTIFICIAL NEURAL NETWORK (ANN) TO PREDICT CIRRHOSIS IN CHRONIC HEPATITIS C (CHC). COMPARISON WITH A LOGISTIC REGRESSION (LG) MODEL

M. Cazzaniga; G. Borroni; Roberto Ceriani; P. Guerzoni; M.A. Casiraghi; Francesco Salerno


Journal of Hepatology | 2013

909 IMPACT OF DEMOGRAPHIC CHARACTERISTICS ON RESPONSE TO PEGYLATED INTERFERON/RIBAVIRIN TREATMENT IN GENOTYPE 2 AND 3 CHC PATIENTS

G. Spinzi; M. Andreoletti; G. Borroni; A. Bortoli; M.A. Casiraghi; M. Cazzaniga; Roberto Ceriani; P. Guerzoni; B. Omazzi; S. Paggi; M.G.L. Pich; A. Prada; N. Terreni


Digestive and Liver Disease | 2013

P.18.7 IMPACT OF AGE AND SEX ON RESPONSE TO THERAPY WITH PEGYLATED INTERFERON PLUS RIBAVIRIN IN GENOTYPE 2 AND 3 CHRONIC HEPATITIS C PATIENTS

G. Spinzi; M. Andreoletti; G. Borroni; Aurora Bortoli; M.A. Casiraghi; M. Cazzaniga; R. Ceriani; P. Guerzoni; G. Mandelli; B. Omazzi; M.G.L. Pich; Alberto Prada; N. Terreni

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Aurora Bortoli

Vita-Salute San Raffaele University

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