G. Borroni
University of Milan
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Featured researches published by G. Borroni.
Journal of Hepatology | 1994
Francesco Salerno; Alberto DelBo; Alessandra Maggi; Monica Marabini; Maria Maffi; G. Borroni; Pamela Moser
Water retention is a complication in many patients with cirrhosis, usually attributed to excessive release of arginine vasopressin. To investigate the responsiveness of arginine vasopressin to osmotic and non-osmotic stimuli and its relationship to free water excretion, we studied 19 patients with cirrhosis under three different conditions: 45 min with legs raised to 60 degrees, to expand the central blood volume; infusion of 1000 ml of 0.45% saline solution to reduce plasma osmolality; and rapid injection of 50 ml of 2 M NaCl to increase plasma osmolality. Both expansion of central blood volume and decrease of plasma osmolality significantly reduced plasma vasopressin levels (from 2.1 +/- 0.6 to 1.39 +/- 0.3 pg/ml, p < 0.04; and from 1.09 +/- 0.25 to 0.41 +/- 0.13 pg/ml, p < 0.0001). The changes in free water excretion differentiated two subgroups of patients during each test: excretors and non-excretors. In the excretors, increased free water excretion was associated with suppressed vasopressin levels (below 0.5 pg/ml) and normal renal function. In the non-excretors, inability to improve free water excretion was associated with high vasopressin levels or with reduced distal delivery of the glomerular filtrate, except in some cases where vasopressin levels had fallen below 0.5 pg/ml and renal function was normal. For these cases the presence of other vasopressin-independent antidiuretic mechanisms is conceivable. The injection of hypertonic saline solution caused significant rises in plasma osmolality (from 287 +/- 1.9 to 292 +/- 1.6 mmol/kg, p < 0.05) and in plasma vasopressin levels (from 1.13 +/- 0.29 to 2.86 +/- 0.52 pg/ml, p < 0.05). These results suggest that vasopressin release in patients with cirrhosis is normally responsive to osmotic and non-osmotic stimuli, although our results show a lower theoretical osmolar threshold for suppression of vasopressin release in non-excretors than in excretors (276 vs 284 mmol/kg).
Digestive and Liver Disease | 2011
R. Ceriani; M. Andreoletti; G. Borroni; Aurora Bortoli; M.A. Casiraghi; M. Cazzaniga; P. Guerzoni; G. Mandelli; B. Omazzi; M.G.L. Pich; Alberto Prada; N. Terreni; G. Spinzi
REDUCED RENAL FUNCTION IS ASSOCIATEDWITH ANEMIA DURING TREATMENT WITH PEGINTERFERON/RIBAVIRIN IN ELDERLY CHRONIC HEPATITIS C PATIENTS R. Ceriani∗ ,1, M. Andreoletti 2 , G. Borroni 3, A. Bortoli 4 , M. Casiraghi 5, M. Cazzaniga6 , P. Guerzoni7 , G. Mandelli 8 , B. Omazzi 4, M.G. Pich1, A. Prada4, N. Terreni 8, G. Spinzi 8 1Irccs Istituto Clinico Humanitas, Rozzano (MI), Italy; 2Ospedale A Manzoni, Lecco, Italy; 3Asl Milano 1, Milano, Italy; 4Ospedale G Salvini, Rho (MI), Italy; 5Ospedale Civile, Legnano, Italy; 6Irccs Policlinico S. Donato, S Donato Milanese (MI), Italy; 7Ospedale Varese, Varese, Italy; 8Ospedale Valduce, Como, Italy
The American Journal of Gastroenterology | 1993
Francesco Salerno; G. Borroni; Pamela Moser; Badalamenti S; Cassarà L; Alessandra Maggi; Fusini M; Bruno Cesana
Digestive and Liver Disease | 2000
G. Borroni; Alessandra Maggi; A. Sangiovanni; M. Cazzaniga; Francesco Salerno
Hepatology | 1992
Salvatore Badalamenti; G. Borroni; Elettra Lorenzano; Pierluigi Incerti; Francesco Salerno
Hepatology | 1996
Francesco Salerno; G. Borroni; Elettra Lorenzano; Daniela Solenghi; M. Cazzaniga; Franco Bissoli; Roberto Ceriani; Roberto DeFranchis
Journal of Hepatology | 2004
G. Borroni; M. Cazzaniga; Roberto Ceriani; M.A. Tommasini; C. Maltempo; C. Felline; A. Maggi
Journal of Hepatology | 2008
M. Cazzaniga; G. Borroni; Roberto Ceriani; P. Guerzoni; M.A. Casiraghi; Francesco Salerno
Journal of Hepatology | 2013
G. Spinzi; M. Andreoletti; G. Borroni; A. Bortoli; M.A. Casiraghi; M. Cazzaniga; Roberto Ceriani; P. Guerzoni; B. Omazzi; S. Paggi; M.G.L. Pich; A. Prada; N. Terreni
Digestive and Liver Disease | 2013
G. Spinzi; M. Andreoletti; G. Borroni; Aurora Bortoli; M.A. Casiraghi; M. Cazzaniga; R. Ceriani; P. Guerzoni; G. Mandelli; B. Omazzi; M.G.L. Pich; Alberto Prada; N. Terreni