G. Candiano

Characterization of a Silicon Strip Detector and a YAG:Ce Calorimeter for a Proton Computed Radiography Apparatus

Today, there is a steadily growing interest in the use of proton beams for tumor therapy, as they permit to tightly shape the dose delivered to the target reducing the exposure of the surrounding healthy tissues. Nonetheless, accuracy in the determination of the dose distribution in proton-therapy is up to now limited by the uncertainty in stopping powers, which are presently calculated from the photon attenuation coefficients measured by X-ray tomography. Proton computed tomography apparatus (pCT) has been proposed to directly measure the stopping power and reduce this uncertainty. Main problem with proton imaging is the blurring effect introduced by multiple Coulomb scattering: single proton tracking is a promising technique to face this difficulty. As a first step towards a pCT system, we designed a proton radiography (pCR) prototype based on a silicon microstrip tracker (to characterize particle trajectories) and a segmented YAG:Ce calorimeter (to measure their residual energy). Aim of the system is to detect protons with a ~1 MHz particle rate of and with kinetic energy in the range 250-270 MeV, high enough to pass through human body. Design and development of the pCR prototype, as well as the characterization of its single components, are described in this paper.

Monte Carlo Studies of a Proton Computed Tomography System

Proton therapy is a precise forms of radiation therapy that makes use of high energy proton compared to the conventional, more commonly used and less precise x-ray and electron beams. On the other hand, to fully exploit the proton therapy advantages, very accurate quality controls of the treatments are required. These are mainly related to the dose calculations and treatment planning. Actually dose calculations are routinely performed on the basis of X-ray computed tomography while a big improvement could be obtained with the direct use of protons as the imaging system. In this work we report the results of Monte Carlo simulations for the study of an imaging system based on the use of high energy protons: the proton computed tomography (pCT). The main limitation of the pCT and the current adopted technical solutions, based on the use of the most likely path (MLP) approximation are illustrated. Simulation results are compared with experimental data obtained with a first prototype of pCT system tested with 200 MeV proton beams available at the Loma Linda University Medical Center (LLUMC) (CA).

The Energy Selection System for the laser-accelerated proton beams at ELI-Beamlines

ELI-Beamlines is one of the four pillars of the ELI (Extreme Light Infrastructure) pan-European project. It will be an ultrahigh-intensity, high repetition-rate, femtosecond laser facility whose main goals are the generation and applications of high-brightness X-ray sources and accelerated charged particles. In particular medical and multidisciplinary applications with laser-accelerated beams are treated by the ELIMED task force, a collaboration between different research institutes. A crucial goal for this network is represented by the design and the realization of a transport beamline able to provide ion beams with suitable characteristics in terms of energy spectrum and angular distribution in order to perform dosimetric tests and biological cell irradiations. A first prototype of transport beamline has been already designed and some magnetic elements are already under construction. In particular, an Energy Selector System (ESS) prototype has been already realized at LNS-INFN. This paper reports about the studies of the ESS properties as, for instance, energy spread and transmission efficiency, carried out using the GEANT4 Monte Carlo code.

A New Thomson Spectrometer for high energy laser-driven beams diagnostic

Thomson Spectrometers (TPs) are widely used for beam diagnostic as they provide simultaneous information on charge over mass ratio, energy and momentum of detected ions. A new TP design has been realized at INFN-LNS within the LILIA (Laser Induced Light Ion Acceleration) and ELIMED (MEDical application at ELI-Beamlines) projects. This paper reports on the construction details of the TP and on its experimental tests performed at PALS laboratory in Prague, with the ASTERIX IV laser system. Reported data are obtained with polyethylene and polyvinyl alcohol solid targets, they have been compared with data obtained from other detectors. Consistency among results confirms the correct functioning of the new TP. The main features, characterizing the design, are a wide acceptance of the deflection sector and a tunability of the, partially overlapping, magnetic and electric fields that allow to resolve ions with energy up to about 40 MeV for protons.

Development of a proton computed radiography apparatus

There is today a growing up interest in proton therapy for tumor treatment, because these particles permit to tightly shape the dose to the target. Anyway, the accuracy in the determination of dose distribution for proton therapy is presently limited by the uncertainty in stopping power distribution, which is calculated from the photon attenuation coefficients measured by X-ray tomography. A proton computed tomography apparatus (pCT) could be used to directly measure stopping power and reduce this uncertainty. The main problem with proton imaging is the blurring effect introduced by multiple Coulomb scattering, but single proton tracking is a promising technique to face this difficulty. As a first step toward a pCT system, we designed a proton radiography (pCR) prototype based on a silicon microstrip tracker to characterize particle trajectories and on a segmented YAG:Ce calorimeter to measure their residual energy. The target is to detect protons with initial kinetic energy in the range 250-270 MeV and with a particle rate of ∼1MHz. Design and development of the pCR prototype, as well as the characterization of its single components, are described in this article. Status of development of reconstruction algorithms capable to account for Coulomb scattering is reported too.

Detailed Monte Carlo investigation of a proton computed tomography system

Proton therapy is a precise form of radiation therapy and thus it requires accurate quality control of patients treatment. Protons may be more suitable than conventional X-rays for this task since the relative electron density distribution can be measured directly with proton computed tomography (pCT). However, proton CT has its own limitation. The main limit is that of spatial resolution limited by multiple coulomb scattering of proton inside the body of patient. In order to improve spatial resolution we need to determine the most likely path of single proton inside the body. In this work we realized a set of Monte Carlo simulations for the calculation of the most likely path

The radiobiology of laser-driven particle beams: focus on sub-lethal responses of normal human cells

Accelerated proton beams have become increasingly common for treating cancer. The need for cost and size reduction of particle accelerating machines has led to the pioneering investigation of optical ion acceleration techniques based on laser-plasma interactions as a possible alternative. Laser-matter interaction can produce extremely pulsed particle bursts of ultra-high dose rates (≥ 109 Gy/s), largely exceeding those currently used in conventional proton therapy. Since biological effects of ionizing radiation are strongly affected by the spatio-temporal distribution of DNA-damaging events, the unprecedented physical features of such beams may modify cellular and tissue radiosensitivity to unexplored extents. Hence, clinical applications of laser-generated particles need thorough assessment of their radiobiological effectiveness. To date, the majority of studies have either used rodent cell lines or have focussed on cancer cell killing being local tumour control the main objective of radiotherapy. Conversely, very little data exist on sub-lethal cellular effects, of relevance to normal tissue integrity and secondary cancers, such as premature cellular senescence. Here, we discuss ultra-high dose rate radiobiology and present preliminary data obtained in normal human cells following irradiation by laser-accelerated protons at the LULI PICO2000 facility at Laser Lab Europe, France.

Absolute and relative dosimetry for ELIMED

The definition of detectors, methods and procedures for the absolute and relative dosimetry of laser-driven proton beams is a crucial step toward the clinical use of this new kind of beams. Hence, one of the ELIMED task, will be the definition of procedures aiming to obtain an absolute dose measure at the end of the transport beamline with an accuracy as close as possible to the one required for clinical applications (i.e. of the order of 5% or less). Relative dosimetry procedures must be established, as well: they are necessary in order to determine and verify the beam dose distributions and to monitor the beam fluence and the energetic spectra during irradiations. Radiochromic films, CR39, Faraday Cup, Secondary Emission Monitor (SEM) and transmission ionization chamber will be considered, designed and studied in order to perform a fully dosimetric characterization of the ELIMED proton beam.

Medical research and multidisciplinary applications with laser-accelerated beams: the ELIMED netwotk at ELI-Beamlines

Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikalni ustar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

Assembling and test of a proton computed radiography apparatus

Proton Computed Tomography (pCT) is a medical imaging method, based on the use of proton beams with kinetic energy of the order of 250 MeV, aimed to directly measure the stopping power distribution of tissues (presently calculated from X-rays attenuation coefficients), thus improving the accuracy of treatment planning in hadron therapy. A pCT system should be capable to measure tissue electron densities with an accuracy better than 1% and with a spatial resolution better than 1 mm. The blurring effect due to multiple Coulomb scattering can be circumvented by single proton tracking. As a first step toward pCT, we designed a proton computed radiography (pCR) prototype capable to carry out a single projection. The pCR apparatus includes a tracker (based on identical tracker modules, each including a silicon microstrip detector) to measure proton trajectory and a calorimeter (made of four YAG:Ce optically separated crystals) to measure residual energy. The tracker modules have been extensively tested and calibrated with beta particles and 62 MeV protons. The calorimeter has been tested with 62MeV and 200MeV protons, as well. The tracker assembly and the test of the tracker modules coupled to the calorimeter are presently under way. Results from these experiments are presented in this contribution.