G. Chandrashekar

Highly efficient cleavage of epoxides catalyzed by B(C6F5)3

A highly effective protocol for ring opening of epoxides with allyl and propargyl alcohols, aniline and thiophenol in the presence of catalytic amounts of B(C 6 F 5 ) 3 has been developed. Benzyl, tetrahydropyranyl, tert-butyldimethyl silyl protecting groups were stable under the reaction conditions.

Formation of left-handed helices in hybrid peptide oligomers with cis β-sugar amino acid and L-Ala as building blocks

Residue based control of specific helical folding is explored in hybrid peptide oligomers consisting of alternating L-Ala and cis-beta-furanoid sugar amino acid (FSAA) residues as building blocks; two series of these hybrid oligomers are designed, synthesized and extensively characterized by using NMR, CD, FT-IR and MD simulation studies; results show the co-existence of left-handed 11- and 14/15-helical conformations in these short oligomers of Boc-(alpha/beta) and Boc-(beta/alpha) series.