G. Collura

Retrograde ureteroscopy for distal ureteric stone removal in children.

A wide range of topics is covered in the Paediatric Urology section in this months issue: retrograde ureteroscopy for distal ureteric stones, outcomes of continent catheterizable stomas for urinary and faecal incontinence, an exploration of a possible common cause between enuresis in childhood and urinary and faecal incontinence in adult life, and a description of a new surgical procedure, the colpo‐wrap.

Renal damage in vesico-ureteric reflux.

To detect the different extent of renal parenchymal involvement in primary vesico‐ureteric reflux (VUR), and to evaluate the relationship between VUR grade, patient age and different patterns of parenchymal damage.

Cystitis glandularis in children

To assess the characteristics of cystitis glandularis in children.

Severe Primary Obstructive Megaureter in the First Year of Life: Preliminary Experience With Endoscopic Balloon Dilation

BACKGROUND AND PURPOSE Although conservative management is indicated in most cases of primary obstructed megaureter (POM), surgery is still indicated when POM is associated with increasing dilation, symptoms, or progressive renal damage. Surgery is associated with a significant rate of complications, however, especially in the case of very large ureter in the first year of life. A valid alternative could be endoscopic high pressure balloon dilation (EHPBD) of the vesicoureteral junction (VUJ). We report the first experience with EHPBD in patients under 1 year of age who were affected by severe POM. PATIENTS AND METHODS Five patients, aged between 6 and 12 months, were treated with EHPBD. In all patients, preoperative renal ultrasonography showed a distal ureteral dilation ≥15 mm that increased at later evaluations; an obstructive pattern was detected by preoperative diuretic renography. An 8-9,8 F cystoscope, and a 3F balloon catheter (balloon maximum diameter 4 mm) was used. The VUJ was dilated for 5 minutes at 12 to 14 atm. A 4.7F Double-J stent was then positioned and left in place for 6 to 8 weeks. Ultrasonography was performed every 3 months, and renography and voiding cystourethrography the fourth month after the EHPBD. RESULTS No operative complications were observed. All the patients showed an improvement at the ultrasonography postoperative follow-up, and there was no evidence of obstruction/reflux at the postoperative check up. CONCLUSIONS Our preliminary results seem to indicate that EHPBD is a feasible, safe, and successful procedure. It could play a role as a minimally invasive alternative to open surgery in cases of POM that necessitate intervention in the first year of life. Longer follow-up is necessary to verify the stability of these results.

Primary obstructive megaureter in infants: our experience with endoscopic balloon dilation and cutting balloon ureterotomy.

The management of primary obstructive megaureter (POM) is usually conservative, at least in the first year of life. Nevertheless, in high-grade POMs with increasing dilation, obstructive patterns found at renography, or cases involving decreased renal function, there is a clear indication for surgery. From January 2009 to March 2013, 12 patients, aged 6 to 12 months (mean 8 months), were treated endoscopically for POM. At the procedure, a clear stenotic ring was identified in 10 of the 12 patients, and a simple endoscopic high-pressure balloon dilation (EHPBD) was well performed in 7 patients. In the three cases with persistent ring, a cutting balloon ureterotomy (CBU) was then performed, resulting in the immediate and complete disappearance of the stenosis. In two cases, no ring could be seen at the procedure, and they showed no improvement at the follow-up. The mean follow-up was 21 months. Considering the whole series of patients treated endoscopically, the overall success rate of EHPBD+CBU was 83%. Patients with POM can be treated endoscopically. In the case of a persistent ring that is unresponsive to EHPBD, CBU seems to provide a valid definitive treatment of POM.

Hydronephrosis due to Malrotationin a Pelvic Ectopic Kidney withVascular Anomalies

A particular case of hydronephrosis in ectopic kidney due to a malrotation and vascular anomalies in a young girl is described. The patient was previously operated for ureteropelvic junction obstruction at the age of two. Clinic and radiographic and pathologic findings are discussed and the literature is reviewed.

Microperc for pediatric nephrolithiasis: technique in valdivia-modified position.

INTRODUCTION Micropercutaneous nephrolithotomy (microperc) has been recently proposed in adult patients. We present our initial experience in children using a modified technical approach. METHODS After the retrograde positioning of a 5F catheter, a 4.85F metallic needle (1.9 mm) was used for direct percutaneous calyceal access under ultrasonographic and fluoroscopic guidance with the patient in supine Valdivia-modified position. Once a three-way connector was inserted to the needle, stone fragmentation was performed under direct vision using a 200 μm holmium:YAG laser fiber and a 0.9-mm high-resolution (10,000 pixels) optic flexible wire connected with the telescope, with intermittent saline infusion. The transureteral catheter was removed within 18 to 24 hours. RESULTS A total of five patients aged 18 months to 11 years (mean, 5.8 years) received microperc lithotripsy in a 6-month period. The mean stone size was 15.0 mm (± 2.5 mm). Conversion to retrograde intrarenal surgery was necessary in one case, due to stone migration and poor visibility. Moderate hydronephrosis was present in one kidney. The mean operative time was 56 minutes (± 23 minutes). The blood loss was insignificant (< 0.6 Hbg/dL) and postoperative discomfort was minimal. The mean hospital stay was 2.4 ± 0.6 days for four patients after the removal of ureteral catheter. The JJ stent was removed after 15 days in the last patient. The overall stone-free rate at 1 month was 100% and no ancillary procedures were required. Conclusions Microperc is a new cost-effective and time-saving technique that we demonstrated as safe and effective in minimally invasive procedure for lower pole and pelvic renal stones of small size. Indications and limits should be defined by multicenter randomized studies, comparing the former procedures.

Renal transplant donation from a deceased cardiac graft recipient: a case for marginal donors.

Abstract:  We describe a case of dual kidney transplant in a highly sensitized 18‐yr‐old male patient followed for chronic renal failure secondary to focal and segmental glomerulosclerosis. The donor was a six‐yr‐old boy who had received a cardiac transplant at the age of three months and had been treated with CNIs for over five yr. Renal biopsy performed before the transplant revealed focal sclerosis in 30–40% of the donor’s glomeruli. Considering the long expected time on the waiting list for this highly sensitized boy and the absence of prohibited antigens in the donor, we decided to perform the transplant. To increase renal mass, both kidneys were transplanted. Clinical course was good but the patient developed proteinuria, which improved with ramipril. We performed two renal biopsies in the first nine months post‐transplant which showed a progressive increase of the glomerulosclerosis. Despite the histology, renal function remains good 24 months after transplant. This is the first report of a transplant using a kidney from a donor who had received long‐term CNI treatment. Short‐term outcome is satisfactory. We suggest that marginal donors could also be considered for donation in pediatric age for selected groups of patients.

Arterial Changes in Children Undergoing Renal Transplantation

INTRODUCTION Pathological changes of large arterial walls and the heart have been described in patients with chronic renal failure. The aim of the study was to verify the incidence of arterial changes among our series of pediatric patients with end-stage renal disease undergoing transplantation. PATIENTS AND METHODS From January 2004 to December 2006, 26 patients (15 boys and 11 girls) of overall mean age of 13.12 years (range=3-27 years) underwent renal transplantation in our department. The pretransplant dialysis treatment was peritoneal in eight and hemodialysis in 18 cases. All patients were divided in two groups according to primary renal disease: group A were 18 patients with congenital urinary malformations; and group B, eight patients with acquired glomerular diseases. In each case, a sample of artery from both donor (aortic patch of kidney) and recipient (iliac patch of graft allocation) was obtained during renal transplantation. The donors were considered to be the control group. RESULTS Light microscopy showed pathological changes in 12/26 recipient arteries: nine showed light fragmentation of the internal elastic lamina; two, more severe fragmentations; and one, fragmentation of the internal elastic lamina associated with mucopolysaccharide deposits. Pathological changes were more evident in group A than B, but the difference was not significant (P> .05). Among the donor group, 11 patients showed light fragmentation of the internal elastic lamina, but there was no significant difference with the recipients (P> .05). CONCLUSIONS Among our group of patients, we observed only slight modifications of the arterial wall. These changes were nonspecific, similar to those in a control group of donors matched for age. A possible explanation of these findings may depend on the short time of dialysis before transplantation.

Retrograde Ureteroscopy for Distal Ureteral Stones Removal in Childhood

Distal ureteral stones are commonly treated by extracorporeal shock wave lithotripsy (ESWL) as first option in adult age patients, but no agreement is achieved about the treatment in children. Efficacy and safety of ureteroscopy with ureterolithotripsy (ULT) was compared with ESWL results for distal ureteral calculi treatment in childhood. Materials e Methods From July 2002 to July 2003, paediatric patients presenting ureteral stones were consecutively randomized for treatment, using ULT or ESWL. The success rate, effectiveness quotient, complication rate and hospitalization length were evaluated. T-Student test (chi-square) was adopted for statistical analysis. Results A total of 31 patients, aged 2 to 17 years (mean age 7.2 years) were recruited. ULT was performed in 17 children. All the females (100%) and 4 males (80%) were stone-free in a single endoscopic procedure. ESWL was performed as a primary procedure in 14 cases, 5 males and 9 females. Four females (44.4%) and 2 males (40%) resulted stone-free at first treatment. The total stone-free rate was 94.1% for ULT and 42.8% for ESWL (p=0.004). Eight patients (57%) underwent a second ESWL and 3 of them (37.5%) became stone-free súbsequently. The 5 patients (62.5%) with failed double ESWL underwent ULT successfully. The calculated efficiency quotient for treating distal ureteral calculi was significantly lower in the ESWL than in the ULT group (p=0.05). Conclusions ULT should be recommended as treatment of choice for distal ureteral calculi in childhood. Using small ureteroscopes the target stone was treated safety and effectively in our patients.