G da Silva

In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts

Maytenus heterophylla (Eckl & Zeyh.) Robson and Maytenus senegalensis (Lam). Exell are two African medicinal plants used to treat painful and inflammatory diseases. We evaluated the in vivo (per os) anti-inflammatory activity of M. heterophylla leaf, stem and root extracts and of M. senegalensis leaf and stem extracts. Additionally, we assessed their in vivo acute and sub-acute toxicities. Anti-inflammatory activities of ethanol extracts were determined in Wistar albino rats, by the carrageenan-induced paw oedema method. Acute and sub-acute toxicity screening of the extracts was evaluated in adult male CD-6 mice. Leaf extracts of M. heterophylla and M. senegalensis exhibited significant anti-inflammatory activity (120 mg/kg, per os), reducing oedema by 51% and 35%, respectively. While M. heterophylla extracts at 1200 mg/kg have shown to be non-toxic, M. senegalensis extracts indicated some toxicity. Our results show a significant anti-inflammatory effect of both M. heterophylla and M. senegalensis leaf extracts in a local model of acute inflammation and suggest the absence of acute and sub-acute toxicity signs of the M. heterophylla leaf extract (but not of M. senegalensis). Ongoing studies will surely shed some light into the mechanism of action of this active extract and establish its chemical fingerprint.

Maytenus heterophylla and Maytenus senegalensis, two traditional herbal medicines

Maytenus heterophylla (Eckl. and Zeyh.) N.K.B. Robson and Maytenus senegalensis (Lam.) Exell are two African shrubs or trees that go under the common name of spike thorn, which belong to the Celastraceae family. Different plant parts of this species are largely used in traditional medicine for infectious and inflammatory diseases treatment. Several studies have been reported for both these species, but there are no recent review articles focusing microscopic, phytochemistry and pharmacological studies. The aim of this review is to summarize the information about these two African traditional medicines. Such kind of data can be applied in future experimental work and may guide future studies, namely in the field of validation of traditional medicine.

Emerald — European Medical Radiation Learning Development — for Vocational Training and Interactive Learning on World Wide Web — Nuclear Medicine Training Module

EMERALD is an EC-funded Leonardo da Vinci pilot project in which three common transnational vocational training modules in Medical Radiation Physics are developed; Physics in Diagnostic Radiology, Nuclear Medicine and Radiotherapy. They will be delivered for training of graduate and postgraduate students. Each module, following a syllabus and a workbook for students, will last about four months. It incorporates material for interactive computerbased learning and distance learning on CD-ROMs, as well as a database of technical and physical images (i.e. equipment, phantom images, simulated images, artefacts, etc.). An extension of the EMERALD project considers the design of an electronic course and conversion to network-based material on interactive WWW-pages for on-line initial vocational training (IVT) and continuing vocational training (CVT) in “life long learning and training”.