G. Fyrmpas
Aristotle University of Thessaloniki
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Featured researches published by G. Fyrmpas.
International Seminars in Surgical Oncology | 2006
G. Fyrmpas; Nikolaos Barbetakis; Andreas Efstathiou; Iordanis Konstantinidis; Christodoulos Tsilikas
BackgroundFacial skin metastases from colorectal cancer are extremely rare and appear several years after resection of the primary tumour. They are an important finding, often being the first sign of metastasis from a previously treated colon cancer.Case presentationWe describe a case of a 69 year old patient with cutaneous metastasis to the chin from a previously treated adenocarcinoma of the colon. The patient presented with dyspnoea, pleuritic pain and loss of weight. A chest x-ray revealed a right upper lobe mass of the lung which on subsequent surgical exploration proved to be metastatic from colorectal adenocarcinoma resected three years ago. During the postoperative course, a nodule was noted on the chin and excision biopsy revealed it was also a metastasis from the initial colorectal cancer. Palliative chemoradiotherapy was administered and the patient survived 8 months.ConclusionHigh index of suspicion is necessary for the early detection of facial cutaneous metastases from colorectal cancer. The aim is to start treatment as soon as possible before widespread visceral metastases occur. Cutaneous metastases from colorectal cancer carry a better prognosis in comparison to those of other epithelial tumours.
Journal of Laryngology and Otology | 2009
G. Fyrmpas; Wurm J; Athanassiadou F; Papageorgiou T; Beck Jd; Heinrich Iro; Jannis Constantinidis
BACKGROUND AND AIM Rhabdomyosarcoma is the commonest malignant tumour of the nose and paranasal sinuses in the paediatric population. Due to its rarity and largely unknown biological behaviour, the treatment of this tumour is complex and controversial. We present the results of multimodality treatment of paediatric sinonasal rhabdomyosarcoma, and we explore the role of surgery in the management of this malignancy. METHODS We retrospectively reviewed the records of 14 patients (median age 7.5 years) with sinonasal rhabdomyosarcoma. Six patients underwent major surgery with post-operative chemoradiation. Eight patients received multi-agent chemotherapy and radiotherapy. The mean follow-up time was 58 months (range seven to 276 months). RESULTS The five-year overall survival rates for all patients and for the surgery group were 53.9 and 83.3 per cent, respectively. All patients with alveolar rhabdomyosarcoma had a poor prognosis, with a median survival time of 17 months. Intracranial extension and an age greater than 10 years were also associated with an unfavourable outcome. Non- or partial responders to initial chemoradiation died within a year of diagnosis. CONCLUSIONS Management of paediatric rhabdomyosarcoma requires a combination of chemotherapy, radiotherapy and surgery. Primary chemoradiotherapy is the established treatment approach for advanced tumours. Early stage tumours with favourable histology can be treated successfully with radical surgery, provided that function and cosmetic appearance are preserved.
Journal of Laryngology and Otology | 2014
G. Fyrmpas; Iordanis Konstantinidis; Panagiotis Selviaridis; Jannis Constantinidis
BACKGROUND Closure of spontaneous sphenoid sinus cerebrospinal fluid leaks can be challenging because of the relative inaccessibility of the lateral recess and the presence of intracranial hypertension. We present our experience of such cases and highlight factors associated with a successful outcome. METHODS Eleven patients with spontaneous, laboratory confirmed, sphenoid sinus cerebrospinal fluid leaks were included. All patients underwent endoscopic closure by either a three-layer technique or fat obliteration. RESULTS In all but one patient, the leak was successfully sealed (success rate, 90.9 per cent; mean follow up, 37.1 months). Elevated intracranial pressure was measured in eight patients, two of whom did not exhibit relevant clinical or radiological characteristics. Five patients received diuretics and dietary advice for weight reduction. In one patient with recurrence two weeks after repair, successful revision was performed by additional placement of a ventriculoperitoneal shunt (follow up, 67 months). CONCLUSION Long-lasting cerebrospinal fluid fistula sealing in the sphenoid sinus requires stable reconstruction of the defect in three layers or fat obliteration if the anatomy is unfavourable. All patients should be intra- and post-operatively screened for elevated intracranial pressure to identify those who need additional intracranial pressure reduction measures.
Journal of Laryngology and Otology | 2010
G. Fyrmpas; Jannis Constantinidis; Nikolaos Foroglou; Panagiotis Selviaridis
OBJECTIVE To highlight the possibility of pituitary apoplexy after functional endoscopic sinus surgery for elimination of sinonasal infection, an important preparatory step for safe trans-sphenoidal access to the pituitary fossa. CASE REPORT A 67-year-old man with a known pituitary macroadenoma developed headache, diplopia and reduced vision after endoscopic middle meatal antrostomy and ethmoidectomy for rhinosinusitis with polyps. Magnetic resonance imaging showed pituitary haemorrhage. The patient underwent emergency endoscopic trans-sphenoidal resection of the tumour, with significant symptomatic improvement. Despite mild right eyelid ptosis and persistent diabetes insipidus, the patient resumed normal activities in a few weeks. To our knowledge, this is the first report of pituitary apoplexy after a nasal operation. CONCLUSION Pituitary apoplexy is a rare and potentially life-threatening event in high risk patients with pituitary adenomas; it may occur spontaneously or after surgical procedures. Early, combined surgical intervention by rhinologists and neurosurgeons is recommended. The endoscopic trans-sphenoidal approach is a safe and effective technique for the acute management of pituitary apoplexy.
European Archives of Oto-rhino-laryngology | 2008
G. Fyrmpas; Iordanis Konstantinidis; D. Hatzibougias; Victor Vital; Jannis Constantinidis
European Archives of Oto-rhino-laryngology | 2012
G. Fyrmpas; Iordanis Konstantinidis; J. Constantinidis
Auris Nasus Larynx | 2009
G. Fyrmpas; Demitrios Rachovitsas; Anna-Bettina Haidich; Jiannis Constantinidis; Stefanos Triaridis; Victor Vital; Meltiadis Tsalighopoulos
European Archives of Oto-rhino-laryngology | 2008
G. Fyrmpas; D. Televantou; V. Papageorgiou; F. Nofal; Jannis Constantinidis
Acta Otorhinolaryngologica Italica | 2007
Iordanis Konstantinidis; S Paschaloudi; Stefanos Triaridis; G. Fyrmpas; S Sechlidis; Jiannis Constantinidis
European Archives of Oto-rhino-laryngology | 2006
G. Fyrmpas; J. Constantinidis; D. Televantou; Iordanis Konstantinidis; J. Daniilidis