G. M. Cooper
Bristol Royal Infirmary
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Featured researches published by G. M. Cooper.
Anaesthesia | 1982
G. M. Cooper; A. M. Scoggins; I. D. Ward; D. Murphy
The metabolic and hormonal response to laparoscopy was investigated in 22 patients, in whom nitrous oxide‐oxygen anaesthesia was supplemented with either 150 μg fentanyl or an Althesin infusion. There were significant increases in plasma cortisol (p < 0.05) from 303 to 458 mmol/litre and prolactin from 1869 to 3918 mU/litre (p < 0.01) at the end of laparoscopy in both groups of patients; these were sustained during the first hour of the recovery period. The blood glucose concentration increased significantly (p < 0.05) from 4.48 to 5.28 mmol/litre at the end of laparoscopy in the Althesin patients and remained increased 1 hour postoperatively at 5.54 mmol/litre (p < 0.01). The blood glucose concentration increased significantly (p < 0.05) from 4.43 to 5.36 mmol/litre in the fentanyl patients only during the recovery period. There was no significant difference between the metabolic and hormonal changes observed with the two anaesthetic techniques.
Anaesthesia | 1988
K.L. Kong; G. M. Cooper
Recovery of neuromuscular function and postoperative morbidity were studied in 51 fit female patients who had nonemergency gynaecological laparoscopy as inpatients. They were allocated randomly to one of three groups to receive either atracurium 0.31 mg/kg, alcuronium 0.25 mg/kg, or vecuronium 0.06 mg/kg as part of an otherwise standard anaesthetic technique. There were neither differences in intubation conditions nor in the occurrence of postoperative diplopia whichever muscle relaxant was used. Deficits in grip strength and expiratory force were seen at one hour after reversal with atropine 1.2 mg and neostigmine 2.5 mg in all patients, deficits which persisted for 3 hours in those who received alcuronium. The recovery of inspiratory force, was slower and less complete at up to 3 hours in those who received alcuronium and there was a high incidence of minor postoperative morbidity at up to 24 hours in each of the three groups. The only statistical difference in symptomatic morbidity was an increase in muscle weakness in those who received alcuronium compared with atracurium at 3 hours after laparoscopy. Only 25Va, 20% and 31% of the patients who received atracurium, alcuronium and vecuronium respectively said that they would have liked to be day stay patients.
Anaesthesia | 1980
J. W. Sear; G. M. Cooper; N.B. Williams; P.J. Simpson; C. Prys-Roberts
Minaxolone citrate, a new water‐soluble steroid intravenous anaesthetic, has been compared with Althesin as an induction agent and subsequently intermittently supplemented by nitrous oxide and oxygen alone for anaesthesia for short surgical procedures. Short term recovery following Minaxolone was significantly slower than after Althesin, but 1 h after the end of anaesthesia, no differences could be detected between the two groups of patients. Minaxolone, given by intravenous increments to supplement nitrous oxide following an induction dose of 0·5 mg/kg, appears to provide satisfactory anaesthesia for short surgical procedures.
Anaesthesia | 1983
N. W. Goodman; G. M. Cooper; A. F. Malins; C. Prys-Roberts
Patients, aged 36 to 78 years, who had participated in two studies that included the ventilatory effects of postoperative analgesia, returned a questionnaire canvassing their views of the procedure for obtaining consent and the conduct of the study. Fourteen of 18 patients from one study, and all 18 from the second, returned their questionnaires. Thirty of the 32 patients were satisfied with the pre‐operative explanation. Eleven patients felt obliged to take part, not because of coercion, but from a sense of duty to others. The breathing tests caused discomfort to eight patients but only one of them found this more than expected from the pre‐operative explanation. Only two patients, both in the second study, said that they would not volunteer again for a similar study. There was no suggestion that the age of the patient or the fact that they were undergoing major surgery had any influence on their attitudes or comprehension. It may be prudent to use this type of questionnaire to evaluate the response of patients to some research projects.
Anaesthesia | 1983
J. W. Sear; G. M. Cooper; V. Kumar
Eighty unpremedicated patients undergoing dilatation and curettage were randomly allocated to receive induction of anaesthesia with either Althesin or thiopentone prior to maintenance with nitrous oxide, oxygen and halothane. Patients in each group were divided into those under 50 years (‘young’) or over SO years (‘old’). Recovery was assessed by the time taken to opening their eyes, to give correct date of birth and to achieve their baseline ability of manipulative skill with a childrens post box toy. There was no difference in the time taken to open eyes or give correct birth date whether the patients received Althesin or thiopentone, or whether they were ‘young’ or ‘old’. An age‐related difference emerged with the post box test inpatients who had received thiopentone, the older patients recovery time being increased from 28.5 minutes to 45.1 minutes. There was no difference between the old and young patients who received Althesin in the time taken to complete the post box test.
Survey of Anesthesiology | 1986
J. A. Carter; A. M. Dye; G. M. Cooper
Sixty unpremedicated patients undergoing dilatation and curettage were allocated randomly to receive one of three inhalational agents (halothane, enflurane or isoflurane) to supplement 67% nitrous oxide in oxygen after induction of anaesthesia with methohexitone. Recovery was assessed by the time patients took to open their eyes, to give their correct date of birth, to regain their pre-operative level of manipulative skill with a childrens postbox toy, and by comparing pre-operative and postoperative performance of a paper and pencil test (the p-deletion test). There was no difference in the time to open eyes or to regain their pre-operative score with the postbox whether the patients received halothane, enflurane or isoflurane. Patients in the isoflurane group took longer than patients in the enflurane group to give their correct date of birth, but they performed better in the p-deletion test postoperatively, completing more lines with the same number of errors. Patients receiving enflurane committed more errors postoperatively in the p-deletion test. The incidence of complications was low and was not influenced by the choice of inhalational agent.
Anaesthesia | 1983
V. Kumar; J. Harvey; G. M. Cooper
One hundred and twenty unpremedicated patients, scheduled for minor gynaecological procedures, were randomly allocated to receive Althesin or methohexitone to supplement N2O and O2 anaesthesia. Patients were assessed as thin, medium or fat according to the degree of obesity as measured by skinfold calipers. The range of mean times for the patients to open their eyes was 3.1–4.0 minutes, to be orientated was 4.4–6.7 minutes and to perform a manipulative test was 27.7–32.1 minutes. No statistically significant differences were seen in these indices of recovery whether they received Althesin or methohexitone or whether they were thin, medium or fat. A paper and pencil test was also performed.
Survey of Anesthesiology | 1987
P. M. Mcateer; J. A. Carter; G. M. Cooper; C. Prys-Roberts
Isoflurane was compared with halothane as the sole supplement to anaesthesia with nitrous oxide and oxygen for outpatient dental extractions in 80 children. Induction and maintenance of anaesthesia were satisfactory with both agents, although there was a higher incidence of coughing, salivation and laryngospasm in the group receiving isoflurane. However, in contrast to predictions from the physical properties of isoflurane and halothane, immediate recovery was significantly slower in patients who had received isoflurane. Recovery was complicated by coughing in a significant number of patients in the isoflurane group. The incidence of reported complications during later recovery was similar with both agents, apart from the complaint of non-specific postoperative aches in a significant number of patients to whom isoflurane was administered.
Anaesthesia | 1982
J.A. Carter; A. M. Dye; G. M. Cooper
Anaesthesia | 1983
M. E. Sinclair; G. M. Cooper