G.M. De Ferrari
University of Pavia
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Featured researches published by G.M. De Ferrari.
Circulation | 1991
F Nador; G Beria; G.M. De Ferrari; M Stramba-Badiale; E H Locati; A Lotto; Peter J. Schwartz
BackgroundThe idiopathic long QT syndrome (LQTS) is characterized by electrocardiographic abnormalities and by a high incidence of lethal arrhythmias. The present case/control study demonstrates the frequent occurrence of unusual and specific ventricular wall motion abnormalities in LQTS and their association with history of syncope or cardiac arrest. These anomalies were present in 23 of 42 LQTS patients (55%) and in two of 42 healthy controls (5%, p < 0.0001) matched for age, sex, height, and weight. Methods and ResultsTwo new measurements were developed to assess quantitatively the abnormalities observed. The first, Thl/2, is an index of the rapidity of the early contraction phase; the second, TSTh, is an index of the presence of a slow movement in the late thickening phase. Thl/2 was smaller in LQTS patients (15.0 + 4.1 versus 19.9 + 3.9% of the cardiac cycle, p < 0.001), indicating that they reach half-maximal systolic contraction more rapidly than controls. TSTh was greater in LQTS patients (9.37 ± 6.82 versus 2.88 ± 4.46%, p < 0.001), indicating that they spend more time at a very low thickening rate. A peculiar double peak pattern of late thickening was present in 11 patients and in no controls. These abnormalities were more frequent in symptomatic than in asymptomatic patients (20 of 26, 77%, versus three of 16, 19%, p < 0.005; relative risk, 2.75). They were not affected by α-blockade or by left cardiac sympathetic denervation. The same echocardiographic abnormalities were produced by right stellectomy in nine of nine anesthetized dogs, were not dependent on cycle length, and were not modified by subsequent left stellectomy. ConclusionsThis study demonstrates a previously unsuspected abnormality in the ventricular contraction pattern of LQTS patients and, for the first time, provides evidence that a noninvasively detected cardiac abnormality is associated with a higher risk for syncope/cardiac arrest. The experimental reproduction of this echocardiographic abnormality by right stellectomy indicates that this newly found clinical characteristic of LQTS does not contradict the “sympathetic imbalance” hypothesis.
European Heart Journal | 2018
Claudia Raineri; Claudia Pavesi; Annalisa Turco; Stefano Ghio; Laura Scelsi; Adele Valentini; Emilio Bassi; Veronica Dusi; Barbara Petracci; Simone Savastano; Antonio Sanzo; A. Vicentini; Roberto Rordorf; L. Oltrona Visconti; G.M. De Ferrari
European Heart Journal | 2018
Federico Guerra; Pietro Palmisano; Veronica Dusi; G Dell'era; Valentina Catto; D Facchin; S Simovic; O Fabregat; Michele Accogli; G.M. De Ferrari; Eraldo Occhetta; Corrado Carbucicchio; Alessandro Proclemer; Laura Cipolletta; Alessandro Capucci; Electra investigators
European Heart Journal | 2018
A. Demarchi; Stefano Cornara; Alberto Somaschini; G. Crimi; M Ferlini; Rita Camporotondo; M. Ferrario Ormezzano; Massimiliano Gnecchi; L. Oltrona Visconti; S. De Servi; G.M. De Ferrari
European Heart Journal | 2018
M Ferlini; Federico Fortuni; Antonella Potenza; G. Crimi; S. Mauri; Stefano Cornara; Alberto Somaschini; A Balduini; G.M. De Ferrari; L. Oltrona Visconti
European Heart Journal | 2018
Enrico Baldi; Alessandra Palo; Aurora Ilaria Danza; Fabrizio Canevari; Chiara Mosca; Simone Molinari; Michele Pagani; Bruno Lusona; Francesco Mojoli; Roberta Bertona; Riccardo Osti; G.M. De Ferrari; L. Oltrona Visconti; Simone Savastano; Pavia Care researchers
European Heart Journal | 2018
Veronica Dusi; Luigi Pugliese; S Castelletti; Federica Dagradi; Lia Crotti; A. Mori; Rita Camporotondo; Claudia Raineri; Laura Scelsi; Stefano Ghio; Simone Savastano; A. Vicentini; Roberto Rordorf; P. J. Schwartz; G.M. De Ferrari
European Heart Journal | 2018
Federico Fortuni; C Crimi; Sergio Leonardi; Filippo Angelini; Arturo Raisaro; Luca Lanzarini; L. Oltrona Visconti; Maurizio Ferrario; G.M. De Ferrari
European Heart Journal | 2018
Alberto Somaschini; G. Crimi; Stefano Cornara; Stefano Buratti; Marco Ferlini; Rita Camporotondo; Massimiliano Gnecchi; D Bartolini; S Belotti; M Fedele; A Iannone; F Beccaria; L. Oltrona Visconti; Paolo Rubartelli; G.M. De Ferrari
European Heart Journal | 2018
Stefano Cornara; G. Crimi; Stefano Buratti; Alberto Somaschini; M Ferlini; Rita Camporotondo; Massimiliano Gnecchi; D Bartolini; S Belotti; M Fedele; A Iannone; F Beccaria; L. Oltrona Visconti; Paolo Rubartelli; G.M. De Ferrari