G. Morin

Les syndromes autoimmuns multiples, mythe ou réalité ?

Disorders of autoimmune pathogenesis are occurring with increased frequency in patients with a previous history of another autoimmune disease. This way, the combinaison of at least three autoimmune diseases in the same patient provides a Multiple Autoimmune Syndrome (MAS). It is believed that the MAS could help to prevent the occurrence of a new condition in a patient previously affected by two others. The purpose of this paper is to report 10 new cases of MAS, in which the third autoimmune disease was prevented using this new classification.

Le lymphome angiotrope : à propos de 2 cas

Malignant angioendotheliomatosis, actually called angiographic lymphoma, is a rare disease characterized by an intravascular proliferation of malignant lymphoid cells in small arteries. Clinical expressions are mostly consisted in cutaneous lesions, neurologic signs, fever and asthenia. Chemotherapy is used, but the prognosis is very poor.

Diabète lipoatrophique, acanthosis nigricans, hypertrophie musculaire, atteinte osseuse. Une observation exceptionnelle du syndrome de Berardinelli

We report an exceptionnal case of Berardinelli syndrome with osteolytic and osteocondensation bone lesions associated with insulino-resistant diabetes mellitus, hyperlipidemia, muscular-over-development, hirsutism and loss of adipose tissue.

Paralysie périodique hypokaliémique précédant de 5 ans la découverte d'une thyrotoxicose chez un asiatique

We report a case of 30 year-old asiatic man with acute thyrotoxic periodic paralysis (TPP). He had experienced multiple similar episodes for five years. Primary diagnosis was Westphal syndrome. T.P.P. although rare, may occur in caucasian patients and should be considered in the differential diagnosis of muscle weakness.

Trois observations atypiques de fièvre hémorragique avec syndrome rénal

We report 3 cases of haemorragic fever with renal syndrome (HFRS). The first case presented with neuropathy, the second case with plasmocytosis, the third case with benign thrombepenia. These cases increase physician awareness of HFRS protean manifestations.

Efficacité du méthotrexate dans un cas de sarcoïdose cutanée floride

Methotrexate is a good therapy in cutaneous sarcoidosis when others treatments are ineffective or with adverse effects. The doses are low and allow to continue the therapy many months. This treatment is often used after corticosteroids or APS.

La thrombocytose dans la maladie cœliaque de l'adulte : un argument en faveur d'un hyposplénisme associé ?

In the present study, 22 patients with coeliac disease were analysed for the frequency of thrombocytosis. 57 % of them were having a thrombocytosis more than 500 × 103/mm3. Our results confirmed that functionnal hyposplenism is frequently associated with coeliac disease. Its pathogenesis is unknown. We concluded that thrombocytosis is common in adulthoods coeliac diagnosed, and may be an argument for the diagnosis.

À l'ombre de la spasmophilie : les myopathies enzymatiques de l'adulte. Leur diagnostic : une affaire d'interniste

Adults enzymopathic myopathies may be confused with spasmophilia in consideration of the normality of the clinical examination, electromyographic studies and muscle enzymes levels, when studied at rest. We report 6 cases of different enzymatic myopathies which give an illustration of such a confusion.

Les manifestations systémiques de la maladie de Gougerot-Sjögren primitive : responsabilité d'une hyper-perméabilité intestinale ?

51 CR-EDTA test for intestinal permeability was performed in 22 patients with Sjogren syndrome. Hyperpermeability was detected in 16 patients (73 %) and was more frequent and pronounced in patients with systemic features than in those with sicca syndrom alone.