G. N. Mehta

New and Improved Synthesis of Telmisartan: An Antihypertensive Drug

Abstract An improved, cost-effective, and industrially advantageous process suitable for large-scale production of telmisartan 1 has been described. The key steps include Suzuki coupling for the preparation of key intermediate 2-(4′-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 10 of telmisartan, N-alkylation, and oxazoline hydrolysis.

Improved Synthesis of Valsartan via Nucleophilic Aromatic Substitution on Aryloxazoline

Abstract A highly efficient approach to the synthesis of the angiotensin II receptor antagonist valsartan (Diovan), one of the most important agents used in antihypertensive therapy today is described. The formation of the aryl–aryl bond represents the key step of its synthesis, which has been done by simple nucleophelic aromatic substitution on aryloxazoline with good yield and purity.

Efficient Syntheses of (±)-Cherylline and Latifine Dimethyl Ether

A concise route for the syntheses of (±)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet–Spengler cyclization.

IMPEDANCE TECHNIQUE TO STUDY PASSIVITY OF STEEL

ABSTRAT Steel was exposed to 0.1M sodium nitrite solution. Corrosion potentials and impedances were measured at the intervals of 3, 27 and 96 hours. The corrosion potential shifted towards the noble direction, the interfacial capacitance remained unchanged with elapse of time. However, the extent of these changes was initially higher, upto 27 hours and then decreased to almost half during the next interval. While this higher extent indicated the onset and expansion, the lesser extent reflected plugging of the defects and the growth, of the passive film on the steel surface. The corrosion current density, calculated as supporting data from the charge transfer resistance, decreased with ealpse of time.

Convenient synthesis of amaryllidaceae alkaloid, (+/–) latifine dimethyl ether

A short route for the synthesis of (+/-) latifine dimethyl ether is reported. The key steps involved are Grignard reaction, conversion of alcohol to nitrile using trimethylsilyl cyanide, reduction of the nitrile intermediate followed by Pictet–Spengler cyclisation and reductive N-methylation in a single step to provide latifine dimethyl ether as a racemate.

An efficient synthesis of (+/-) cherylline dimethyl ether

A concise route for the synthesis of (+/-) cherylline dimethyl ether is reported. The key steps involved are Grignard reaction, conversion of alcohol to nitrile using (N-(p-toluene sulfonyl)imidazole and sodium cyanide), reduction of the nitrile intermediate followed by Pictet–Spengler cyclisation and reductive N-methylation in a single step to provide cherylline dimethyl ether as a racemate.