G. Volpe

Fetal cardiac evaluation at 11–14 weeks by experienced obstetricians in a low‐risk population

The aim of this study was to evaluate the detection rate of congenital heart diseases (CHD) in a low‐risk population by performing cardiac evaluation during the first‐trimester screening for chromosomal abnormalities. In this context, the role of four‐chamber view, tricuspid regurgitation and abnormal ductus venosus flow in the screening for cardiac anomalies in a low‐risk population was also investigated.

Aberrant right subclavian artery (ARSA) in unselected population at first and second trimester ultrasonography

To evaluate the feasibility of examining aberrant right subclavian artery (ARSA) at first and second trimester gestation, its prevalence and associations in an unselected population.

Abnormal sonographic appearance of posterior brain at 11–14 weeks and fetal outcome

The aim of this retrospective study was to describe the sonographic appearance of the posterior brain anatomy in normal fetuses at 11 to 14 weeks of pregnancy and to determine the fetal outcome when one of the posterior brain anatomical space is not recognized.

The three‐vessel and trachea view (3VTV) in the first trimester of pregnancy: an additional tool in screening for congenital heart defects (CHD) in an unselected population

The aim of the study was to evaluate the feasibility of obtaining the three‐vessel and trachea view (3VTV) in an unselected population undergoing first trimester screening for aneuploidy, and to investigate its role in the early detection of congenital heart defects (CHD).

EP04.44: Accuracy of early fetal echocardiography within 16 weeks of gestation in the diagnosis of aortic arch anomalies in a high-risk population

Objectives: Ductus venous (DV) evaluation is used today in detection of major cardiac abnormalities and for aneuploidy screening at 11-13+6 weeks’ scan. Our aim was the development of an objective method for identifying abnormal / negative DV a-wave by semi-quantitative analysis of DV waveform. Methods: Depending to the aspect of the a-wave, the active ventricular filling during atrial systole, DV flows were classified into normal, false or real negative a-wave. We calculated the S/V, S/D and V/D ratios, where S ventricular systole (S-wave) V – ventricular tele-diastolic relaxation, D passive ventricular diastolic filling (waveform D). Were considered unique, singleton fetuses with a Crown–rump length of 45-84 mm. Studied cases were retrospectively identified in 2009-2016 database, classified with possible or real negative DV a-wave. 439 normal pregnancies, with positive DV a-wave, prospectively evaluated during 2015-2016, formed the control group. Results: Were available for analysis 436 cases a-wave positive, 37 with a-wave false positive and 24 with a-wave real negative. The average values of S/V and S/D ratios were significantly different among all three study groups, having a progressive increase from the normal towards the true negative form, respectively 1.48±0.15, 1.67±0.17 and 2.08±0.75 for S/V; 1.19±0.06, 1.23±0.06 and 1.33±0.15 for S/D (means ± standard deviation). Mean value for V/D ratio was greater for the flow with a-wave positive, but there were no significant differences between groups with the a-wave false or real negative. Conclusions: Semi-quantitative assessment of DV blood flow waveform can facilitate recognition of negative a-waves.

OC11.03: *Velum interpositi cyst: is it a benign finding?

loss occurred in 10.4% and 1.6% of children with 1st and 2nd trimester infection, respectively. One child with deafness treated with cochlear implant and one child diagnosed with mild CP, (attributed to prematurity) both after 1st trimester infection. Three children, after 2ed trimester infection, diagnosed with hypotonia (2) and mild developmental delay (1). Nineteen patients had abnormal sonographic findings (4 with normal MRI, and 10 with subtle MRI findings). Of those, 3 (15.7%) had damage to the auditory system. Two other fetuses had very abnormal US findings (refuse TOP) and they suffered severe neurologic damage. In all cases infection occurred during the 1st trimester. None of the children infected during the third trimester were affected. Conclusions: The outcome of congenital primary CMV infection with normal prenatal US and MRI is favorable. The prognostic value of subtle MRI findings is probably limited and as an isolated finding it probably does not justify termination of pregnancies.

OP12.11: Comparison of the cardiac findings at 11 to 14 weeks' gestation with the second trimester findings

Conclusions: Congenital malformations of the tricuspid valve are known to show a gradation of changes, ranging from Ebstein’s malformation with downward displacement of the valvar leaflets inisolation, through combinations of displacement and dysplasia, to exclusive dysplasia of normally attached leaflets. Several studies have described the prenatal diagnosis of tricuspid valve disease at advanced gestational age, but none addressed the early prenatal diagnosis of tricuspid valve disease. This study addressed for the first time the early prenatal diagnosis of tricuspid valve disease.

OC02.05: Fetal echocardiography at 11–14 weeks by experienced obstetricians in a routine population during first trimester US screening for chromosomal abnormalities

C. B. Miltoft1, C. K. Ekelund1, B. M. Hansen2, A. Lando2, O. B. Petersen3, P. Skovbo4, F. S. Jørgensen5, L. Sperling6, H. Zingenberg7, A. Nikkila8, A. C. Shalmi9, I. Stornes10, V. Ersbak11, A. Tabor1 1Fetal Medicine and Ultrasound, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 2Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Department of Obstetrics and Gynaecology, Aarhus University Hospital, Skejby, Aarhus, Denmark; 4Department of Obstetric and Gynaecology, Aalborg University Hospital, Aalborg, Denmark; 5Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark; 6Department of Obstetrics and Gynecology, Copenhagen University Hospital, Herlev, Copenhagen, Denmark; 7Department of Obstetrics and Gynecology, Copenhagen University Hospital, Glostrup, Copenhagen, Denmark; 8Department of Obstetrics and Gynecology, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark; 9Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hillerød, Copenhagen, Denmark; 10Department of Obstetrics and Gynecology, Randers Hospital, Randers, Denmark; 11Department of Obstetrics and Gynecology, Silkeborg Hospital, Silkeborg, Denmark