G. W. Morgan

Antibody Responses to Xenogeneic Red Blood Cell Challenge in the Japanese Quail

Previous reports indicate that Japanese quail are hyporesponsive to such conventionally used antigens as sheep red blood cells and bovine serum albumin. In this study the immune responsiveness of Japanese quail to several erythrocyte antigens was investigated. The quail produced higher antibody titers when immunized with chukar red blood cells than when immunized with sheep, turkey, or pheasant red blood cells. It is concluded that Japanese quail are capable of producing HA titers comparable in magnitude to those demonstrated by other laboratory animals, when the quail are immunized with an appropriate antigen. Chukar red blood cells are such an antigen.

Recrudescence of the thymus and repopulation of lymphocytes during an artificially induced molt in the domestic chicken: Proposed model system

Abstract Thymic recrudescence accompanied by a lymphocytic repopulation was induced in Single Comb White Leghorn (SCWL) hens by an artificially induced molt. Molting induction involved manipulating the photoperiod combined with periods of food and water deprivation. Thymic recrudescence was evidenced by an increase in size and number of thymic lobes and repopulation of cortical lymphocytes. Lymphocytic repopulation occurred only in molting hens, and upon resumption of reproduction, the thymus again regressed. Artificially induced molting is a model system for studying the immunologic, physiologic, and endocrinologic effects of lymphocytic repopulation in the thymus.

Ontogeny of delayed hypersensitivity in young turkeys

Hypersensitivity to phytohemagglutinin (PHA-P) and Freunds adjuvant containing Mycobacterium tuberculosis was investigated in turkey poults. The kinetics, as indicated by dosage and response time after sensitization, were similar to responses in other birds and laboratory mammals. Newly hatched poults demonstrated delayed hypersensitivity responses, and 2 week old poults exhibited responses of greater magnitude than 8 week old poults. The turkey is proposed as another acceptable species for study of cell-mediated immunity (CMI).