Gábor Szabad
University of Szeged
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Featured researches published by Gábor Szabad.
PLOS ONE | 2011
Bernadett Kormos; Nóra Belső; Attila Bebes; Gábor Szabad; Sarolta Bacsa; Márta Széll; Lajos Kemény; Zsuzsanna Bata-Csörgő
In previous work we described a novel culture technique using a cholera toxin and PMA-free medium (Mel-mix) for obtaining pure melanocyte cultures from human adult epidermis. In Mel-mix medium the cultured melanocytes are bipolar, unpigmented and highly proliferative. Further characterization of the cultured melanocytes revealed the disappearance of c-Kit and TRP-1 and induction of nestin expression, indicating that melanocytes dedifferentiated in this in vitro culture. Cholera toxin and PMA were able to induce c-Kit and TRP-1 protein expressions in the cells, reversing dedifferentiation. TRP-1 mRNA expression was induced in dedifferentiated melanocytes by UV-B irradiated keratinocyte supernatants, however direct UV-B irradiation of the cells resulted in further decrease of TRP-1 mRNA expression. These dedifferentiated, easily accessible cultured melanocytes provide a good model for studying melanocyte differentiation and possibly transdifferentiation. Because melanocytes in Mel-mix medium can be cultured with human serum as the only supplement, this culture system is also suitable for autologous cell transplantation.
Wound Repair and Regeneration | 2008
Nikoletta Nagy; István Németh; Gábor Szabad; Gyözö Szolnoky; Nóra Belsõ; Zsuzsanna Bata-Csörgõ; A. Dobozy; Lajos Kemény; Márta Széll
Syndecan 4 (SDC4), a heparan sulfate proteoglycan, and neuropilin 1 (NRP1), a transmembrane receptor, are both involved in normal wound healing, but little is known about their possible role in venous leg ulcer pathogenesis. We aimed to investigate whether there are any expression abnormalities and/or gene polymorphisms of SDC4 and NRP1 associated with venous leg ulcer. SDC4 showed significantly lower mRNA and protein expression in the uninvolved dermis of venous leg ulcer patients (n=15) compared with controls (n=15; p=0.0136), while NRP1 showed no expression abnormalities. None of the examined SDC4 and NRP1 polymorphisms showed a difference in their allelic distribution between leg ulcer patients (n=92) and controls (n=92). We hypothesize that SDC4 may play an essential role not only in the inflammation and tissue formation phases of normal wound healing, but its expression abnormalities observed in the uninvolved dermis of venous leg ulcer patients may contribute to venous leg ulcer development.
Ulcers | 2013
Nikoletta Nagy; Gábor Szabad; Győző Szolnoky; Zsuzsanna Kiss-László; Éva Dósa-Rácz; Zsuzsanna Bata-Csörgő; Lajos Kemény; Márta Széll
Background. A number of well-known acquired and putative inherited etiological factors contribute to the development of venous leg ulcer (VLU). Aim. In this study we set out to perform a meta-analysis of putative genetic and acquired factors predisposing to VLU development. Methods. VLU patients () were divided into three subgroups in accordance with their acquired etiological factors. The frequencies of four genetic factors were determined: the R506Q (Leiden) mutation of the F5 gene, the G20210A mutation of the F2 (prothrombin) gene, the 2451 A/G SNP of the fibroblast growth factor receptor 2 (FGFR2) 3′ UTR, and the −308 G/A SNP of the tumor necrosis factor α (TNFA) promoter. Results. The −308 TNFA SNP exhibited a higher frequency among VLU patients without known acquired predisposing factor in their history, than among patients with thrombosis or soft tissue infection in their history (Fisher ). Conclusions. This study has demonstrated that the group of VLU patients is heterogeneous in their genetic predisposing factors. Further large-scale studies are needed to delineate the associations among genetic and acquired etiological factors with regard to VLU development and to integrate the consequences of the already known genetic factors to the management of VLU.
Journal of Investigative Dermatology | 2000
Zsuzsa Darvas; Hargita Hegyesi; Valéria László; Márta Bencsáth; András Falus; Mary Haak-Frendscho; Sarolta Kárpáti; Randall L. Hoffman; Csaba Szalai; József Fürész; József Tímár; Zsuzsanna Bata-Csorgo; Gábor Szabad; Andor Pivarcsi; Éva Pállinger; Lajos Kemény; Attila Horváth; A. Dobozy
Journal of Investigative Dermatology | 2005
Nikoletta Nagy; Győző Szolnoky; Gábor Szabad; Z. Bata-Csörgö; A. Dobozy; Lajos Kemény; Márta Széll
Archive | 2005
Lajos Kemény; Zsuzsa Bata-Csörgö; Gábor Szabad
Archives of Dermatological Research | 2007
Gábor Szabad; Bernadett Kormos; Andor Pivarcsi; Márta Széll; Kornélia Kis; Anna Szabó; A. Dobozy; Lajos Kemény; Zsuzsanna Bata-Csörgő
Journal of Investigative Dermatology | 2007
Nikoletta Nagy; Gyözö Szolnoky; Gábor Szabad; Zsuzsanna Bata-Csörgõ; Attila Balogh; Gergely Klausz; Yvette Mándi; A. Dobozy; Lajos Kemény; Márta Széll
Journal of Investigative Dermatology | 2007
Nikoletta Nagy; Győző Szolnoky; Gábor Szabad; Zsuzsanna Bata-Csörgõ; Attila Balogh; Gergely Klausz; Yvette Mándi; A. Dobozy; Lajos Kemény; Márta Széll
Archive | 2010
Zsuzsanna Bata; Nóra Belső; Anna Szabó; Mária Kiss; Bernadett Kormos; Hilda Polyánka; Gábor Szabad