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Dive into the research topics where Gabriel Famulari is active.

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Featured researches published by Gabriel Famulari.


Physics in Medicine and Biology | 2017

Microdosimetry calculations for monoenergetic electrons using Geant4-DNA combined with a weighted track sampling algorithm

Gabriel Famulari; P Pater; Shirin A. Enger

The aim of this study was to calculate microdosimetric distributions for low energy electrons simulated using the Monte Carlo track structure code Geant4-DNA. Tracks for monoenergetic electrons with kinetic energies ranging from 100 eV to 1 MeV were simulated in an infinite spherical water phantom using the Geant4-DNA extension included in Geant4 toolkit version 10.2 (patch 02). The microdosimetric distributions were obtained through random sampling of transfer points and overlaying scoring volumes within the associated volume of the tracks. Relative frequency distributions of energy deposition f(>E)/f(>0) and dose mean lineal energy ([Formula: see text]) values were calculated in nanometer-sized spherical and cylindrical targets. The effects of scoring volume and scoring techniques were examined. The results were compared with published data generated using MOCA8B and KURBUC. Geant4-DNA produces a lower frequency of higher energy deposits than MOCA8B. The [Formula: see text] values calculated with Geant4-DNA are smaller than those calculated using MOCA8B and KURBUC. The differences are mainly due to the lower ionization and excitation cross sections of Geant4-DNA for low energy electrons. To a lesser extent, discrepancies can also be attributed to the implementation in this study of a new and fast scoring technique that differs from that used in previous studies. For the same mean chord length ([Formula: see text]), the [Formula: see text] calculated in cylindrical volumes are larger than those calculated in spherical volumes. The discrepancies due to cross sections and scoring geometries increase with decreasing scoring site dimensions. A new set of [Formula: see text] values has been presented for monoenergetic electrons using a fast track sampling algorithm and the most recent physics models implemented in Geant4-DNA. This dataset can be combined with primary electron spectra to predict the radiation quality of photon and electron beams.


Applied Radiation and Isotopes | 2017

Practical aspects of 153Gd as a radioactive source for use in brachytherapy

Gabriel Famulari; Tomas Urlich; Andrea F. Armstrong; Shirin A. Enger

The goal of this study was to investigate the production, purification and immobilization techniques for a 153Gd brachytherapy source. We have investigated the maximum attainable specific activity of 153Gd through the irradiation of Gd2O3 enriched to 30.6% 152Gd at McMaster Nuclear Reactor. The advantage of producing 153Gd through this production pathway is the possibility to irradiate pre-sealed pellets of 152Gd enriched Gd2O3, thereby removing the need to perform chemical separation with large quantities of radio-impurities. However, small amounts of long-lived impurities are produced from the irradiation of enriched 152Gd targets due to traces of Eu in the sample. If the amount of impurities produced is deemed unacceptable, 153Gd can be isolated as an aqueous solution, chemically separated from impurities and loaded onto a sorbent with a high affinity for Gd before encapsulation.


Physics in Medicine and Biology | 2018

RapidBrachyMCTPS: a Monte Carlo-based treatment planning system for brachytherapy applications

Gabriel Famulari; Marc-André Renaud; Christopher M Poole; Michael D.C. Evans; J Seuntjens; Shirin A. Enger

Despite being considered the gold standard for brachytherapy dosimetry, Monte Carlo (MC) has yet to be implemented into a software for brachytherapy treatment planning. The purpose of this work is to present RapidBrachyMCTPS, a novel treatment planning system (TPS) for brachytherapy applications equipped with a graphical user interface (GUI), optimization tools and a Geant4-based MC dose calculation engine, RapidBrachyMC. Brachytherapy sources and applicators were implemented in RapidBrachyMC and made available to the user via a source and applicator library in the GUI. To benchmark RapidBrachyMC, TG-43 parameters were calculated for the microSelectron v2 (192Ir) and SelectSeed (125I) source models and were compared against previously validated MC brachytherapy codes. The performance of RapidBrachyMC was evaluated for a prostate high dose rate case. To assess the accuracy of RapidBrachyMC in a heterogeneous setup, dose distributions with a cylindrical shielded/unshielded applicator were validated against film measurements in a Solid WaterTM phantom. TG-43 parameters calculated using RapidBrachyMC generally agreed within 1%-2% of the results obtained in previously published work. For the prostate case, clinical dosimetric indices showed general agreement with Oncentra TPS within 1%. Simulation times were on the order of minutes on a single core to achieve uncertainties below 2% in voxels within the prostate. The calculation time was decreased further using the multithreading features of Geant4. In the comparison between MC-calculated and film-measured dose distributions, at least 95% of points passed the 3%/3 mm gamma index criteria in all but one case. RapidBrachyMCTPS can be used as a post-implant dosimetry toolkit, as well as for MC-based brachytherapy treatment planning. This software is especially well suited for the development of new source and applicator models.


International Journal of Radiation Oncology Biology Physics | 2018

Microdosimetric evaluation of current and alternative brachytherapy sources - a Geant4-DNA simulation study

Gabriel Famulari; P Pater; Shirin A. Enger


Brachytherapy | 2018

Can Intermediate Energy Sources Result in Increased Bone Doses for Pelvic and Head-and-Neck Brachytherapy?

Gabriel Famulari; Joanne Alfieri; Shirin A. Enger


Brachytherapy | 2018

Rapidbrachymctps: A Monte Carlo Based Treatment Planning System for Brachytherapy Applications

Gabriel Famulari; Marc-André Renaud; Shirin A. Enger


Brachytherapy | 2018

Model Based Dosimetrical Study for Image Guided HDR Brachytherapy Treatment of Rectal Cancer with 192 Ir and 169 Yb

Harry Glickman; Té Vuong; Slobodan Devic; Khaled Adil; Gabriel Famulari; Shirin A. Enger


Physica Medica | 2017

Abstract ID: 41 Consequences of patient heterogeneities for intermediate-energy sources in post-implant assessment of prostate brachytherapy treatment plans

Gabriel Famulari; E Soisson; M. Duclos; Shirin A. Enger


Physica Medica | 2017

Abstract ID: 40 Microdosimetry calculations for monoenergetic electrons using Geant4-DNA combined with a weighted track sampling algorithm

Gabriel Famulari; P Pater; Shirin A. Enger


International Journal of Radiation Oncology Biology Physics | 2017

IMBrachy: A Novel Intensity Modulated High Dose Rate Brachytherapy Delivery System with 169 Yb

Gabriel Famulari; S. Abbasinejad Enger

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E Soisson

McGill University Health Centre

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Michael D.C. Evans

McGill University Health Centre

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