Gabriel L. Plaa

A procedure for estimating the hepatotoxic potential of certain industrial solvents.

Abstract A screening procedure has been described for estimating the hepatotoxic potential of industrial solvents in mice. Data on lethality, barbiturate sleeping time, and bromosulfalein retention, coupled with minimal histologic examination, were employed to determine the individual hepatotoxic potency and relative hepatotoxic potencies for nine halogenated methane derivatives. A method has been described for estimating the industrial hepatotoxic hazard by these data.

Effect of Carbon Tetrachloride on Thioridazine Action and Metabolism.

Summary CCI4 treatment was found to increase both lethal and hypothermic potency of thioridazine. The dose of CCI4 employed produced liver damage but no kidney damage. A method is described for determining thioridazine in tissues. Whole body concentrations of this phenothiazine were found to be significantly higher in mice treated with CCI4.