Gabriela Sentena Severino
Universidade Federal do Rio Grande do Sul
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Publication
Featured researches published by Gabriela Sentena Severino.
Physiology & Behavior | 2004
Gabriela Sentena Severino; Isabel Amaral Martins Fossati; Maristela J. Padoin; Cármen Marilei Gomes; Luciano Trevizan; Gilberto Luiz Sanvitto; Celso Rodrigues Franci; Janete A. Anselmo-Franci; Aldo Bolten Lucion
Neonatal handling induces behavioral and hormonal changes, characterized by reduced fear in novel environments, and lesser elevation and faster return to basal levels of plasma corticosterone, prolactin and adrenaline, in response to stressors in adulthood. The present study aimed to analyze the effects of neonatal handling from Days 1 to 10 postnatal on prolactin response to ether stress in male and female rats at three life periods: neonatal, peripubertal and adulthood. Moreover, adult females were tested in two different phases of the estrous cycle, i.e., diestrus and estrus. In another set of experiments, the behavior of peripubertal and adult males and females in estrus and diestrus was analyzed in the elevated plus maze test. Pups were either handled for 1 min (handled group) or left undisturbed (nonhandled group) during the first 10 days after delivery. In adults, in the handled females in diestrus, stress induced a lesser increase in plasma prolactin compared with nonhandled ones, as in males. However, in estrus, handled females showed no difference in the prolactin response to stress. In the elevated plus maze, handled females in diestrus, but not in estrus, showed higher locomotor activity compared with nonhandled ones. Peripubertal male and female rats handled during the neonatal period showed no difference in behavior in the elevated plus maze compared with nonhandled animals. Early-life stimulation can induce long-lasting behavioral and stress-related hormonal changes, but they are not stable throughout life and phases of the estrous cycle.
Brazilian Journal of Medical and Biological Research | 2001
Erica do Espirito Santo Hermel; Gabriela Sentena Severino; Ana Lúcia Cecconello; Francine Martins Pereira; Gilberto Luiz Sanvitto; Aldo Bolten Lucion
Neonatal handling has long-lasting effects on behavior and stress reactivity. The purpose of the present study was to investigate the effect of neonatal handling on the number of dopaminergic neurons in the hypothalamic nuclei of adult male rats as part of a series of studies that could explain the long-lasting effects of neonatal stimulation. Two groups of Wistar rats were studied: nonhandled (pups were left undisturbed, control) and handled (pups were handled for 1 min once a day during the first 10 days of life). At 75-80 days, the males were anesthetized and the brains were processed for immunohistochemistry. An anti-tyrosine hydroxylase antibody and the avidin-biotin-peroxidase method were used. Tyrosine hydroxylase-immunoreactive (TH-IR) neurons were counted bilaterally in the arcuate, paraventricular and periventricular nuclei of the hypothalamus in 30-microm sections at 120-microm intervals. Neonatal handling did not change the number of TH-IR neurons in the arcuate (1021 +/- 206, N = 6; 1020 +/- 150, N = 6; nonhandled and handled, respectively), paraventricular (584 +/- 85, N = 8; 682 +/- 62, N = 9) or periventricular (743 +/- 118, N = 7; 990 +/- 158, N = 7) nuclei of the hypothalamus. The absence of an effect on the number of dopaminergic cells in the hypothalamus indicates that the reduction in the amount of neurons induced by neonatal handling, as shown by other studies, is not a general phenomenon in the brain.
Archive | 2006
Gabriela Sentena Severino; Aldo Bolten Lucion
Archive | 2004
Mariana Benetti Torres; Gabriela Sentena Severino; Gisele Vieira Rodovalho; Raphael Escorsim Szawka; Janete Aparecida Anselmo Franci; Celso Rodrigues Franci
Archive | 2003
Mariana Benetti Torres; Gabriela Sentena Severino; Tatiane Sabriela Cagol; Janete Aparecida Anselmo Franci; Celso Rodrigues Franci; Gilberto Luiz Sanvitto
Archive | 2002
Ana Lúcia Cecconello; Gabriela Sentena Severino; Aldo Bolten Lucion; Gilberto Luiz Sanvitto
Archive | 1998
Gabriela Sentena Severino; Maristela J. Padoin
Archive | 1997
Lígia M. Barbosa Coutinho; Maristela J. Padoin; Luciana P. Cadore; Cláudia E. de Aguiar; Gabriela Sentena Severino
Archive | 1996
Gabriela Sentena Severino; Laura Verrastro Viñas; Erica do Espirito Santo Hermel
Archive | 1996
Erica do Espirito Santo Hermel; Laura Verrastro Viñas; Gabriela Sentena Severino
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Erica do Espirito Santo Hermel
Universidade Federal do Rio Grande do Sul
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