Gabriella Mezey‐Vándor

Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies

Abstract Novel acridino- and phenazino-18-crown-6 ligands 5 and 6 were prepared from acridine-4,5-diol (9) and phenazine-1,9-diol (10) with tetraethylene glycol di-p-tosylate (11) using potassium teri-butoxide as a base in THF. New optically pure dimethyl-substituted acridino- and phenazino-18-crown-6 ligands (R,R)-7 and (R,R)-8 were also prepared by treating 9 and 10 with optically pure dimethyl-substituted tetraethylene glycol di-p-tosylate [(S,S)-18] . Molecular recognition studies on these novel ligands are underway.

Total synthesis of plagiochins C and D, macrocyclic bis(bibenzyl) constituents of plagiochila acantophylla

Abstract Plagiochins C ( 3 ) and D ( 4 ) were synthesized by convergent schemes. Rings C and B were joined by Ullman ether synthesis, the arylaryl bond between rings A and D was formed by Pd(0)-catalysed coupling of an arylboronic acid (ring D) and a bromobenzoic ester (ring A). Rings C and D were linked by the Wittig reaction, while final ring closure was effected by tetraphenylethene assisted Wurtz reaction.

The synthesis of Garugamblin-1

Abstract The Z isomer of the title compound (21) and its regioisomer (22) were synthesized using an isoxazole synthon (17) for the elaboration of the β-methoxy-enone function. 21 and 20 spontaneously isomerized to the E isomers i.e. to garugamblin-1 (1) and its regioisomer (22) resp.

Ketal mediated diels-alder type dimerization of an arylideneacetone

SummaryDuring ketalization with ethyleneglycol an arylideneacetone1 dimerized via its ketal2 to give a 4-acetyl-3,5-diarylcyclohexanone ketal5.ZusammenfassungBei der Ketalisierung des Arylidenaceton-Derivates1 erfolgt eine Diels-Alder-Dimerisierung des Ethylenketals2 zu einem 4-Acetyl-3,5-diaryl-cyclohexanon5.