Gaetano Dattolo

3-Triazenoindoles. Synthesis and antileukemic activity

Abstract Triazenoindoles of type 3 were synthesized in excellent yields by coupling the 3-diazoindole 1 with the suitable amines. The 3-triazenoindoles 3a-c and the 3-diazoindole 1 showed good cytotoxic activity in vitro against erythroleukemia and multi-drug-resistant cells, with IC50 values in the range 0.053-0.080 μM and 0.10-0.34 μM, respectively.

3-Diazopyrroles—IV. Structure determination using 13C NMR spectroscopy

Abstract On the basis of the 13 C NMR chemical shifts, it is proposed that, although b is the major canonical structure, structure c , in which a negative charge resides at C-3, provides an important contribution to the resonance stabilization of the 3-diazopyrroles, 1–4 .