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Dive into the research topics where Gang Ho Lee is active.

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Featured researches published by Gang Ho Lee.


ACS Nano | 2009

Paramagnetic Ultrasmall Gadolinium Oxide Nanoparticles as Advanced T1 MRI Contrast Agent: Account for Large Longitudinal Relaxivity, Optimal Particle Diameter, and In Vivo T1 MR Images

Ja Young Park; Myung Ju Baek; Eun Sook Choi; Seungtae Woo; Joo-Hyun Kim; Tae-Jeong Kim; Jae Chang Jung; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

Paramagnetic ultrasmall gadolinium oxide (Gd(2)O(3)) nanoparticles with particle diameters (d) of approximately 1 nm were synthesized by using three kinds of Gd(III) ion precursors and by refluxing each of them in tripropylene glycol under an O(2) flow. A large longitudinal relaxivity (r(1)) of water proton of 9.9 s(-1) mM(-1) was estimated. As a result, high contrast in vivo T(1) MR images of the brain tumor of a rat were observed. This large r(1) is discussed in terms of the huge surface to volume ratio (S/V) of the ultrasmall gadolinium oxide nanoparticles coupled with the cooperative induction of surface Gd(III) ions for the longitudinal relaxation of a water proton. It is found from the d dependence of r(1) that the optimal range of d for the maximal r(1), which may be used as an advanced T(1) MRI contrast agent, is 1-2.5 nm.


Chemical Physics Letters | 2002

The cluster size dependence of thermal stabilities of both molybdenum and tungsten nanoclusters

Haekwon Kim; S.H. Huh; Jeong-A Park; J.W. Jeong; Gang Ho Lee

Abstract We measured, for the first time, the oxidation enthalpies of both molybdenum (Mo) and tungsten (W) nanoclusters at several cluster sizes. We observed that the oxidation enthalpies of both Mo and W nanoclusters went down to the corresponding bulk values, respectively, with increasing cluster size. By using the oxidation enthalpies, we estimated the formation enthalpies by using H nanocluster = O nanocluster − O bulk . The formation enthalpies of both Mo and W nanoclusters were all positive and went down to the bulk value (defined as 0 kcal/mol), indicating that the thermal stabilities of both Mo and W nanoclusters improved toward the bulk state with increasing cluster size.


ACS Applied Materials & Interfaces | 2011

A Facile Synthesis, In vitro and In vivo MR Studies of d-Glucuronic Acid-Coated Ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) Nanoparticles as a New Potential MRI Contrast Agent

Krishna Kattel; Ja Young Park; Wenlong Xu; Han Gyeol Kim; Eun Lee; Badrul Alam Bony; Woo Choul Heo; Jae Jun Lee; Seong-Uk Jin; Jong Su Baeck; Yongmin Chang; Tae-Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee

A facile one-pot synthesis of d-glucuronic acid-coated ultrasmall Ln(2)O(3) (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles is presented. Their water proton relaxivities were studied to address their possibility as a new potential MRI contrast agent. We focused on the d-glucuronic acid-coated ultrasmall Dy(2)O(3) nanoparticle because it showed the highest r(2) relaxivity among studied nanoparticles. Its performance as a T(2) MRI contrast agent was for the first time proved in vivo through its 3 T T(2) MR images of a mouse, showing that it can be further exploited for the rational design of a new T(2) MRI contrast agent at high MR fields.


Physical Chemistry Chemical Physics | 2012

Paramagnetic nanoparticle T1 and T2 MRI contrast agents.

Wenlong Xu; Krishna Kattel; Ja Young Park; Yongmin Chang; Tae-Jeong Kim; Gang Ho Lee

There is no doubt that magnetic resonance imaging contrast agents (MRI CAs) can play a vital role in diagnosing diseases. Therefore, demand for new MRI CAs with an enhanced sensitivity and advanced functionalities is very high. Here, paramagnetic nanoparticles (NPs) are reviewed as new potential candidates for either T(1) or T(2) MRI CAs or both. These include surface coated lanthanide (Ln) oxide NPs (Ln = Gd, Dy, and Ho) and manganese oxide NPs. Surface coating materials should be biocompatible and hydrophilic. Compared to conventional large NPs, these surface coated paramagnetic NPs can be made ultrasmall with core particle diameter ranging from 1 to 3 nm, but their magnetic properties are still sufficient for MRI CAs. At this particle diameter, they can be easily excreted from the body through the renal system, which is prerequisite for in vivo applications. Mixed lanthanide oxide NPs into which a fluorescent Ln material is incorporated will be valuable as multiple imaging agents for both MRI-fluorescent imaging (FI) and MRI-cellular imaging (CL). These paramagnetic NPs can be further functionalized towards target-specific imaging, multiplex imaging, and drug delivery.


ACS Applied Materials & Interfaces | 2010

Water-Soluble MnO Nanocolloid for a Molecular T1 MR Imaging: A Facile One-Pot Synthesis, In vivo T1 MR Images, and Account for Relaxivities

Myung Ju Baek; Ja Young Park; Wenlong Xu; Krishna Kattel; Han Gyeol Kim; Eun Lee; Anilkumar Kantilal Patel; Jae Jun Lee; Yongmin Chang; Tae-Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee

A facile one-pot synthesis of a water-soluble MnO nanocolloid (i.e., D-glucuronic acid-coated MnO nanoparticle) is presented. The MnO nanoparticle in the MnO nanocolloid was coated with a biocompatible and hydrophilic D-glucuronic acid, and its particle diameter was nearly monodisperse and ranged from 2 to 3 nm. The average hydrodynamic diameter of the MnO nanocolloid was estimated to be 5 nm. The MnO nanoparticle was nearly paramagnetic down to T=3 K. The MnO nanocolloid showed a high longitudinal water proton relaxivity of r1=7.02 s(-1) mM(-1) with the r2/r1 ratio of 6.83 due to five unpaired S-state electrons of Mn(II) ion (S=5/2) as well as a high surface to volume ratio of the MnO nanoparticle. High contrast in vivo T1 MR images were obtained for various organs, showing the capability of the MnO nanocolloid as a sensitive T1 MRI contrast agent. The suggested three key-parameters which control the r1 and r2 relaxivities of nanocolloids (i.e., the S value of a metal ion, the spin structure, and the surface to volume ratio of a nanoparticle) successfully accounted for the observed r1 and r2 relaxivities of the MnO nanocolloid.


Scientific Reports | 2015

Potential dual imaging nanoparticle: Gd2O3 nanoparticle

Md. Wasi Ahmad; Wenlong Xu; Sung June Kim; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Ji Ae Park; Tae-Jeong Kim; Gang Ho Lee

Gadolinium (Gd) is a unique and powerful element in chemistry and biomedicine which can be applied simultaneously to magnetic resonance imaging (MRI), X-ray computed tomography (CT), and neutron capture therapy for cancers. This multifunctionality can be maximized using gadolinium oxide (Gd2O3) nanoparticles (GNPs) because of the large amount of Gd per GNP, making both diagnosis and therapy (i.e., theragnosis) for cancers possible using only GNPs. In this study, the T1 MRI and CT dual imaging capability of GNPs is explored by synthesizing various iodine compound (IC) coated GNPs (IC-GNPs). All the IC-GNP samples showed stronger X-ray absorption and larger longitudinal water proton relaxivities (r1 = 26–38 s−1mM−1 and r2/r1 = 1.4–1.9) than the respective commercial contrast agents. In vivo T1 MR and CT images of mice were also acquired, supporting that the GNP is a potential dual imaging agent.


Biomaterials | 2012

Paramagnetic dysprosium oxide nanoparticles and dysprosium hydroxide nanorods as T2 MRI contrast agents

Krishna Kattel; Ja Young Park; Wenlong Xu; Han Gyeol Kim; Eun Lee; Badrul Alam Bony; Woo Choul Heo; Seong-Uk Jin; Jong Su Baeck; Yongmin Chang; Tae-Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee

We report here paramagnetic dysprosium nanomaterial-based T(2) MRI contrast agents. A large r(2) and a negligible r(1) is an ideal condition for T(2) MR imaging. At this condition, protons are strongly and nearly exclusively induced for T(2) MR imaging. The dysprosium nanomaterials fairly satisfy this because they are found to possess a decent r(2) but a negligible r(1) arising from L + S state 4f-electrons in Dy(III) ion ((6)H(15/2)). Their r(2) will also further increase with increasing applied field because of unsaturated magnetization at room temperature. Therefore, MR imaging and various physical properties of the synthesized d-glucuronic acid coated ultrasmall dysprosium oxide nanoparticles (d(avg) = 3.2 nm) and dysprosium hydroxide nanorods (20 × 300 nm) are investigated. These include hydrodynamic diameters, magnetic properties, MR relaxivities, cytotoxicities, and 3 tesla in vivo T(2) MR images. Here, MR imaging properties of dysprosium hydroxide nanorods have not been reported so far. These two samples show r(2)s of 65.04 and 181.57 s(-1)mM(-1), respectively, with negligible r(1)s at 1.5 tesla and at room temperature, no in vitro cytotoxicity up to 100 μM Dy, and clear negative contrast enhancements in 3 tesla in vivo T(2) MR images of a mouse liver, which will be even more improved at higher MR fields. Therefore, d-glucuronic acid coated ultrasmall dysprosium oxide nanoparticles with renal excretion can be a potential candidate as a sensitive T(2) MRI contrast agent at MR field greater than 3 tesla.


Journal of Magnetism and Magnetic Materials | 2002

Excellent magnetic properties of fullerene encapsulated ferromagnetic nanoclusters

Gang Ho Lee; S.H. Huh; J.W. Jeong; H.-C. Ri

Abstract Ferromagnetic nanoclusters are very useful for a magnetic recording. However, application of ferromagnetic nanoclusters is limited due to air-oxidation. One way to solve air-oxidation is to encapsulate ferromagnetic nanoclusters with inert materials such as carbon when they are produced. This allows us to keep excellent magnetic properties for a long time. In this work, we report a very simple synthetic method of fullerene (i.e., onions and nanotubes) encapsulated ferromagnetic nickel and cobalt nanoclusters by thermally decomposing metallocene vapors with a resistive heater. Protection from air-oxidation was tested by annealing encapsulated ferromagnetic nanoclusters in air up to ∼180°C for half a day and then, recording XRD patterns. No oxide peaks were observed in the XRD patterns, indicating that oxidation protection via fullerene encapsulation is very good. Magnetic property measurement showed that both fullerene encapsulated nickel and cobalt nanoclusters possessed excellent magnetic properties.


Current Topics in Medicinal Chemistry | 2013

Gadolinium Oxide Nanoparticles as Potential Multimodal Imaging and Therapeutic Agents

Tae-Jeong Kim; Kwon Seok Chae; Yongmin Chang; Gang Ho Lee

Potentials of hydrophilic and biocompatible ligand coated gadolinium oxide nanoparticles as multimodal imaging agents, drug carriers, and therapeutic agents are reviewed. First of all, they can be used as advanced T1 magnetic resonance imaging (MRI) contrast agents because they have r1 larger than those of Gd(III)-chelates due to a high density of Gd(III) per nanoparticle. They can be further functionalized by conjugating other imaging agents such as fluorescent imaging (FI), X-ray computed tomography (CT), positron emission tomography (PET), and single photon emission tomography (SPECT) agents. They can be also useful for drug carriers through morphology modifications. They themselves are also potential CT and ultrasound imaging (USI) contrast and thermal neutron capture therapeutic (NCT) agents, which are superior to commercial iodine compounds, air-filled albumin microspheres, and boron ((10)B) compounds, respectively. They, when conjugated with targeting agents such as antibodies and peptides, will provide enhanced images and be also very useful for diagnosis and therapy of diseases (so called theragnosis).


Scientific Reports | 2013

Mixed lanthanide oxide nanoparticles as dual imaging agent in biomedicine

Wenlong Xu; Badrul Alam Bony; Cho Rong Kim; Jong Su Baeck; Yongmin Chang; Ji Eun Bae; Kwon Seok Chae; Tae-Jeong Kim; Gang Ho Lee

There is no doubt that the molecular imaging is an extremely important technique in diagnosing diseases. Dual imaging is emerging as a step forward in molecular imaging technique because it can provide us with more information useful for diagnosing diseases than single imaging. Therefore, diverse dual imaging modalities should be developed. Molecular imaging generally relies on imaging agents. Mixed lanthanide oxide nanoparticles could be valuable materials for dual magnetic resonance imaging (MRI)-fluorescent imaging (FI) because they have both excellent and diverse magnetic and fluorescent properties useful for dual MRI-FI, depending on lanthanide ions used. Since they are mixed nanoparticles, they are compact, robust, and stable, which is extremely useful for biomedical applications. They can be also easily synthesized with facile composition control. In this study, we explored three systems of ultrasmall mixed lanthanide (Dy/Eu, Ho/Eu, and Ho/Tb) oxide nanoparticles to demonstrate their usefulness as dual T2 MRI–FI agents.

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Yongmin Chang

Kyungpook National University

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Tae-Jeong Kim

Kyungpook National University

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Kwon Seok Chae

Kyungpook National University

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Ji Eun Bae

Kyungpook National University

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Hyunsil Cha

Kyungpook National University

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Jong Su Baeck

UPRRP College of Natural Sciences

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Hee-Kyung Kim

Kyungpook National University

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In Taek Oh

Kyungpook National University

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Ki-Hye Jung

Kyungpook National University

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Seong-Uk Jin

Kyungpook National University

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