Gang-Wei Wang

Palladium-Catalyzed sp2 and sp3 C–H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles

The first Pd(II)-catalyzed C-H addition to isatins by direct sp(2)/sp(3) C-H bond activation for the construction of 3-substituted-3-hydroxy-2-oxindoles is reported. The bidentate nitrogen ligands were found to promote this reaction. Specifically, the preliminary bioassay indicated that 3-(5-chlorobenzoxazole)-3-hydroxy-N-benzyl-2-oxindole (2w) is a new inhibitor of human kidney cancer and hepatocellular carcinoma cells. Moreover, this reaction system exhibits great functional group tolerance and requires no directing group, extra base, or additives.

Cu-catalyzed sp3 C–H bond oxidative functionalization of alkylazaarenes and substituted ethanones: an efficient approach to isoxazoline derivatives

Cu-catalyzed sp3 C–H bond oxidative functionalization of alkylazaarenes and substituted ethanones to different kinds of isoxazoline derivatives by 1,3-dipolar cycloaddition is reported. Cheap sources of nitro, commercially available substrates, as well as a variety of alkenes (alkynes) are applied in this transformation.