Ganga S Pilli

Anencephaly: A pathological study of 41 cases

Background : Anencephaly is a lethal neural tube defect which is due to the defective closure of rostral pore of neural tube. In more than 50% of cases it is associated with other systemic anomalies. Hence this study was undertaken to assess pathological parameters associated with anencephaly in particular attention to associated systemic anomalies. Materials and Methods: It is a study on 41 anencephaly fetuses conducted in the Department of Pathology. The period of study is from January 2001 to December 2011. Results: Out of 41 cases, 30 (73%) cases showed presence of systemic anomalies, 48.5% of the cases were observed in primigravida. Most common associated anomaly was spina bifida followed by gastrointestinal anomalies. Conclusion: Pathological examination of the abortus is essential to document the associated anomalies.

Craniorachischisis Totalis with Congenital Diaphragmatic Hernia—A Rare Presentation of Fryns Syndrome

ABSTRACT Fryns syndrome is a multiple congenital anomaly syndrome with an autosomal recessive inheritance. Here we describe the autopsy case findings of a 19-week male fetus, born out of a consanguineous marriage. The dissection revealed left-sided diaphragmatic hernia, resulting in pulmonary hypoplasia and shift of heart to the right side. In addition, anencephaly and spina bifida throughout the vertebral column were observed. All six criteria for Fryns syndrome were met. Such a presentation of Fryns syndrome associated with Craniorachischisis Totalis has not been reported so far. We have also tabulated the overlapping features of some multiple congenital anomaly syndromes that need to be distinguished at autopsy for an accurate diagnosis.

Squamous cell carcinoma of the middle ear arising from CSOM: A case report

Squamous cell carcinoma occurring in a background of chronic suppurative otitis media (CSOM) is a rare complication. It runs an aggressive course. Hence early identification is significant to prevent disease progression and to improve the survival rate. Subjecting granulation tissue from middle ear for histopathologic examination is of importance to rule out associated malignant change.

Craniospinal rachischisis with multiple anomalies in an anencephalic fetus: A rare case report

Neural tube defects (NTDs) are the most common malformations accounting for 0.5-1.3 cases/1000 live births with multifactorial etiology. Anencephaly and craniospinal rachischisis are open NTDs. Associated malformations are noted in anencephaly, indicating some etiological heterogeneity. Here, we report an anencephalic fetus with craniospinal rachischisis and multiple other anomalies.

Fine needle aspiration cytology of lymph node in erythema nodosum leprosum: A case report with review of literature

The acute manifestations and subsequent complications call for early recognition and management of erythema nodosum leprosum (ENL). Its diagnosis is conventionally based on skin biopsy and slit skin smears. Fine needle aspiration cytology (FNAC) has been found to be a simple and useful tool in the diagnosis of this entity. Lymphadenopathy is a known manifestation of leprosy and its reactions. The present case is reported to underscore the importance of FNAC of lymph node in diagnosis of ENL. A 39-year-old male, known case of lepromatous leprosy on treatment, presented with fever, joint pains, raised lesions all over the body and enlarged bilateral inguinal lymph nodes. FNA of the lymph node revealed characteristic features of ENL. FNA of lymph nodes is simple, non-invasive, useful tool in early diagnosis of ENL.