Gao Cao

4-tert-Butyl-5-(2,4,5-trimethoxy­benz­yl)thia­zol-2-amine

The title compound, C17H24N2O3S, has been synthesized from 2-bromo-4,4-dimethyl-1-(2,4,5-trimethoxyxadphenxadyl)pentan-3-one via cyclization by thioxadurea, acidification by hydrogen bromide which is the by-product of the cyclic reaction, and then neutralization by an aqueous solution of ammonia. Geometric parameters are in the usual ranges. The dihedral angle between the benzene ring and the thiazole ring is 65.9u2005(2)°. The crystal structure shows N—H⋯N and N—H⋯O hydrogen bonds.

2-Amino-4-[4-(benz­yloxy)phen­yl]-5-methyl­thia­zol-3-ium bromide monohydrate

The crystal packing of the hydrated title salt, C17H17N2OS+·Br−·H2O, dominated by an extensive N—H⋯Owater, N—H⋯Br and Owater—H⋯Br hydrogen-bonding network between organic molxadecules, bromine anions and water molxadecules. The anions are located on crystallograpic twofold axes.

5,5′-(1,3-Phenylenedimethylene)bis(2-amino-4-tert-butylthiazol-3-ium) dibromide monohydrate

Geometric parameters of the title salt, C22H32N4S22+·2Br−·H2O, are in the usual ranges. The crystal packing is stabilized by N–H⋯O, N–H⋯Br and O–H⋯Br hydrogen bonds.

(R*)‐(−)‐3‐[4‐(Benzyloxy)benzoylmethyl] 5‐ethyl 2,6‐dimethyl‐4‐(3‐nitrophenyl)‐1,4‐dihydropyridine‐3,5‐dicarboxylate

In the optically active title compound, C32H30N2O8, the substituted 1,4-dihydroxadpyridine ring adopts a flattened boat conformation. The crystal structure is stabilized by interxadmolecular N—H⋯O hydrogen bonding.

(E)-2-[4-tert-Butyl-5-(2,4,5-trimethoxy-benz-yl)thia-zol-2-ylimino-meth-yl]phenol.

In the title compound, C24H28N2O4S, the dihedral angle between the phenol ring and the thiazole ring system is 10.6u2005(1)°, and the trimethoxyphenyl group is approximately perpendicular to the thiazole ring, the dihedral angle being 84.7u2005(2)°. There is a strong intramolecular hydrogen-bonding interaction between the Schiff base and the hydroxy group.

Ethyl 2-methyl-1-(4-phenylthiazol-2-yl)-1H-benzimidazole-6-carboxylate

The title compound, C20H17N3O2S, was prepared by the reaction of ethyl 4-acetamido-3-thioxadureidobenzoate with 2-bromo-1-phenylxadethanone in acetone under reflux, followed by neutralization with ammonia. The molxadecule contains a nonplanar benzimidazole system, displaying a dihedral angle of 1.24u2005(8)°. The dihedral angle between the thiazole and phenyl rings is 3.62u2005(5)°. The crystal structure is stabilized by C—H⋯O hydrogen bonding. The molxadecules are packed in a face-to-face arrangement showing π–π stacking (centroid-to-centroid distance 3.804u2005A).

3-Cinnamyl 5-(2-methoxy­ethyl) 2,6-dimethyl-4-(3-nitro­phen­yl)-1,4-dihydro­pyridine-3,5-dicarboxyl­ate

The title compound, C27H28N2O7, has been synthesized by the reaction of 2-methoxyxadethyl 2-(3-nitroxadbenzylxadidene)acetoxadacetate with cinnamyl 3-aminoxadcrotonate and crystallized from methanol. The substituted 1,4-dihydroxadpyridine ring adopts a flattened boat conformation. The 3-nitroxadphenyl ring is approximately perpendicular to the mean plane of the 1,4-dihydroxadpyridine ring.

1‐(5‐Chloro‐6‐methoxy­naphthalen‐2‐yl)propan‐1‐one

The title compound, C14H13ClO2, has been synthesized from 2-methoxyxadnaphthalene via chlorination by cupric chloride and reaction with propionyl chloride. The 6-methxadoxy and 2-propionyl groups are coplanar with the naphthalene ring system. The molxadecules are packed in a head-to-tail arrangement showing π–π stacking interxadactions.

2-(2,4-Dichloro-5-fluoro­phen­yl)-4-(2-hydroxy­ethyl)morpholin-4-ium chloride

The title compound, C12H15Cl2FNO2+·Cl−, has been synthesized from 2-(2,4-dichloro-5-fluoroxadphenxadyl)-4-(2-hydroxyxadethyl)morpholin-2-ol via reduction by formic acid and acidification by hydrogen chloride. The morpholine unit adopts an almost ideal chair conformation. The crystal structure is consolidated by N—H⋯Cl and O—H⋯Cl interxadmolecular hydrogen bonding.