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Gary A. Howie

Purdue University

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Featured researches published by Gary A. Howie.

Journal of The Chemical Society, Chemical Communications | 1974

Synthesis and stereochemistry of dilactones related to strigol

John M. Cassady; Gary A. Howie

A general approach to the synthesis of strigol (1) analogues has been developed which involves the stereospecific coupling of bromobutenolides (3a) and (3b) with the sodium enolate (2) of 3-(hydroxymethylene)dihydrofuran-2(3H)-one to give dilactones (4a) and (4b) one of which showed significant cytotoxicity against Hela cells in preliminary testing to evaluate the potential anticancer activity of strigol analogues.

Journal of Medicinal Chemistry | 1978

Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids.

Kupchan Sm; Sneden At; Branfman Ar; Gary A. Howie; Rebhun Li; McIvor We; Wang Rw; Schnaitman Tc

Journal of Medicinal Chemistry | 1974

Synthesis of alkyl-substituted .alpha.,.beta.-unsaturated .gamma.-lactones as potential antitumor agents

Gary A. Howie; Peter E. Manni; John M. Cassady

Journal of Medicinal Chemistry | 1976

Potential antitumor agents. Synthesis of bifunctional .alpha.-methylene-.gamma.-butyrolactones

Gary A. Howie; Ioannis K. Stamos; John M. Cassady

Journal of Organic Chemistry | 1972

Simplification of epoxide and lactone proton magnetic resonance spectra using tris(dipivalomethanato)europium shift reagent

Peter E. Manni; Gary A. Howie; Barry. Katz; John M. Cassady

Journal of Organic Chemistry | 1977

Synthesis and structures of dilactones related to anemonin

Ioannis K. Stamos; Gary A. Howie; Peter E. Manni; Warren J. Haws; Stephen R. Byrn; John M. Cassady

ChemInform | 1974

SYNTHESIS OF ALKYL‐SUBSTITUTED ALPHA,BETA‐UNSATURATED GAMMA‐LACTONES AS POTENTIAL ANTITUMOR AGENTS

Gary A. Howie; Peter E. Manni; John M. Cassady

ChemInform | 1978

Tumor inhibitors. 124. Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids

S. Morris Kupchan; Albert T. Sneden; Alan R. Branfman; Gary A. Howie; Lionel I. Rebhun; Wilson E. McIvor; Regina Wen-Jen Wang; Terry C. Schnaitman

ChemInform | 1977

SYNTHESIS AND STRUCTURES OF DILACTONES RELATED TO ANEMONIN

Ioannis K. Stamos; Gary A. Howie; Peter E. Manni; W. J. Haws; Stephen R. Byrn; John M. Cassady

Organic Syntheses | 2003

Methyl α-(Bromomethyl)Acrylate

John M. Cassady; Gary A. Howie; J. Michael Robinson; Ioannis K. Stamos

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John M. Cassady

Ohio State University

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Ioannis K. Stamos

Purdue University

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Stephen R. Byrn

Purdue University

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Albert T. Sneden

University of Virginia

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J. Michael Robinson

Purdue University

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Lionel I. Rebhun

University of Virginia

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S. Morris Kupchan

University of Wisconsin-Madison

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Terry C. Schnaitman

University of Virginia

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