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Featured researches published by Gary D. Madding.


Tetrahedron-asymmetry | 1998

REGIO- AND STEREOSELECTIVE RING OPENING OF EPOXIDE WITH CYANOGUANIDINE DIANIONS, A FACILE SYNTHESIS OF THE KATP OPENER BMS-180448

Bang-Chi Chen; Sandra L. Quinlan; J. Gregory Reid; Paul A. Jass; Tonya P Robinson; William Early; Edward J. Delaney; Michael Humora; Gary D. Madding; John J. Venit; William J. Winter

Abstract BMS-180448, (3S,4R)- 2 , was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with the potassium dianion of cyanoguanidine 11 .


Journal of Heterocyclic Chemistry | 1987

Regioselective syntheses of 2-amino-4,5-dialkylthiophene-3-carboxylates and their conversion to 3,4-dihydro-4-oxothieno[2,3-d]pyrimidine-2-carboxylates

Gary D. Madding; Michael D. Thompson


Organic Process Research & Development | 1997

Process Development of 5-Fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole Dihydrochloride

Neal G. Anderson; Thomas D. Ary; James L. Berg; Peter J. Bernot; Yeung Y. Chan; Chien-Kuang Chen; Merrill L. Davies; John D. Dimarco; Ronald D. Dennis; Rajan P. Deshpande; Hoang D. Do; Roberto Droghini; William Early; Jack Z. Gougoutas; John Anthony Grosso; John C. Harris; Oscar W. Haas; Paul A. Jass; Daniel H. Kim; Gus Kodersha; Atul S. Kotnis; Jean Lajeunesse; David A. Lust; Gary D. Madding; Sandeep P. Modi; Jerome L. Moniot; Andrew Nguyen; Venkatapuram Palaniswamy; Douglas W. Phillipson; James H. Simpson


Journal of Heterocyclic Chemistry | 1985

Synthesis and X-Ray crystal structure of a 2,4,5-trisubstituted 1,2,4-triazolin-3-one

Gary D. Madding; David W. Smith; Robert I. Sheldon; Byungkook Lee


Journal of Organic Chemistry | 2004

Efficient crystallization-induced dynamic resolution of α-substituted carboxylic acids

Susanne Kiau; Robert P. Discordia; Gary D. Madding; Francis J. Okuniewicz; Victor W. Rosso; John J. Venit


Archive | 1989

Process for large-scale production of BMY 21502

Gary D. Madding; Joseph L. Minielli; Ronald J. Mattson


Archive | 2001

Dynamic resolution of isomers and resolved isomers

John J. Venit; Gary D. Madding; Victor W. Rosso; Francis J. Okuniewicz; Robert P. Discordia; Susanne Kiau; Atul S. Kotnis; Michael E. Randazzo; David D. Hennings; Jingyang Zhu; Jason G. Chen


Archive | 1986

4-(2-phenoxyethyl)-1,2,4-triazolone process intermediates

Gary D. Madding


Journal of Heterocyclic Chemistry | 1993

Condensation reactions of activated picolines with anthranilate esters and o-nitrobenzaldehyde: Improved syntheses of the antiarrhythmic drug encainide

John L. Dillon; Richard H Spector; Gary D. Madding; Mary E. Wire


Archive | 1985

Intermediates useful in the preparation of 3,4-dihydro-4-oxothieno[2,3-d]pyrimidine-2-carboxylates and process for preparing same

Michael D. Thompson; Gary D. Madding

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