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Gary Francis Breen

GlaxoSmithKline

Publication

Featured researches published by Gary Francis Breen.

Tetrahedron Letters | 2001

A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A

Ian P Andrews; Richard J Atkins; Neil Francis Badham; Richard K. Bellingham; Gary Francis Breen; John S. Carey; Stephen K. Etridge; Jerome F. Hayes; Nigel Hussain; David O. Morgan; Andrew C. Share; Stephen A. Smith; Timothy Charles Walsgrove; Andrew S. Wells

A new synthesis of lotrafiban SB-214857-A is reported. The key steps are the preparation of racemic (4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid methyl ester from 2-nitrobenzyl alcohol, a resolution using an immobilised lipase enzyme and a palladium-catalysed aminocarbonylation reaction.

Tetrahedron-asymmetry | 2004

Enzymatic resolution of a secondary amine using novel acylating reagents

Gary Francis Breen

Organic Process Research & Development | 2003

The development of a manufacturing route for the GPIIb/IIIa receptor antagonist SB-214857-A. Part 2: Conversion of the key intermediate SB-235349 to SB-214857-A

Richard J. Atkins; Adam Banks; Richard K. Bellingham; Gary Francis Breen; John S. Carey; Stephen K. Etridge; Jerome F. Hayes; Nigel Hussain; David O. Morgan; Paul Oxley; Stephen C. Passey; Timothy Charles Walsgrove; Andrew Wells

Organic Process Research & Development | 1997

Synthetic Routes to Quinoline Derivatives: Novel Syntheses of 3-Butyryl-8-methoxy-4-[(2-methylphenyl)amino]quinoline and 3-Butyryl-8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]quinoline

Richard J. Atkins; Gary Francis Breen; Lynne P. Crawford; Trevor J. Grinter; Michael Anthony Harris; Jerome F. Hayes; Clive J. Moores; Richard Neville Saunders; Andrew C. Share; and Timothy C. Walsgrove; Christopher Wicks

Organic Process Research & Development | 2009

Process Development and Scale Up of a Glycine Antagonist

Adam Banks; Gary Francis Breen; Darren Caine; John S. Carey; Christopher Drake; Michael Anthony Forth; Asa Gladwin; Simone Guelfi; Jerome F. Hayes; Paolo Maragni; David O. Morgan; Paul Oxley; Alcide Perboni; Matthew E. Popkin; Fiona Rawlinson; Guillaume Roux

Archive | 2004

Novel process salts compositions and use

Gary Francis Breen; Michael Anthony Forth; Susan Shumei Hu Kopelman; F. Muller; Francis Dominic Sanderson

Organic Process Research & Development | 2003

The development of a manufacturing route for the GPIIb/IIIa receptor antagonist SB-214857-A. Part 1: Synthesis of the key intermediate 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester, SB-235349

Ian P. Andrews; Richard J. Atkins; Gary Francis Breen; John S. Carey; Michael Anthony Forth; David O. Morgan; Amin Shamji; Andrew C. Share; Stephen A. Smith; Timothy Charles Walsgrove; Andrew Wells

Archive | 2002

Process for preparing 1-methyl-1,2,3,4-tetrahydroisoquinoline or a salt thereof

Gary Francis Breen; Michael Anthony Forth; Matthew E. Popkin

Archive | 2004

Process salts compositions and use

Gary Francis Breen; Michael Anthony Forth; Susan Shumei Hu Kopelman; F. Muller; Francis Dominic Sanderson

Practical Methods for Biocatalysis and Biotransformations 2 | 2012

Industrial Hydrolases and Related Enzymes

Mark Dow; Rebecca Meadows; Rhona Sinclair; Andrew Wells; Gary Francis Breen; John S. Carey; Fiona Rawlinson; K. E. Holt‐tiffin; M. C. Lloyd; Beat Wirz; Paul Spurr; Christophe Pfleger; Graham Checksfield; Stewart T. Hayes; Wilfried Hoffmann; Christian T. Regius; Gemma Scotney; Sarah L. Spencer; Roger M. Howard; Colin M. Burns; Gordon Ward; Robert Walton; Neil Barnwell; Matthew D. Truppo; Gregory Hughes

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