Geetha Jayaram

Effects of anticholinergic medication on memory in schizophrenia.

Verbal memory and reaction time of ten schizophrenic patients were compared at two different serum anticholinergic levels. Verbal recall was worse at higher drug levels, while reaction time tended to be improved by anticholinergic treatment. Implications for studies of memory in schizophrenia are considered.

Practice patterns and treatment choices among psychiatrists in New Delhi, India: a qualitative and quantitative study.

ObjectiveSeveral issues relevant to the care of Asian Indian patients remain poorly explored. Little is known about the practice patterns of psychiatrists in India, such as daily practice routines or treatment approaches, which we describe in New Delhi, India.MethodsWe focused on psychiatric practice, as perceived by Indian psychiatrists, using a sample from the USA as a comparison group. We used triangulated, qualitative methods from data gathered in India (ethnographic interviews with 16 Delhi psychiatrists, observation of treatment in India, and treatment of Indian patients) to design and validate a survey distributed to a sample of 34 psychiatrists in New Delhi and 34 in Baltimore, Maryland who treat Indian patients.ResultsDelhi psychiatrists saw more patients daily (24.3 vs. 11, P < 0.001), and spent less time on new evaluations (33.3 vs. 69 min, P < 0.001). Both groups had similar approaches to major disorders. But, Delhi psychiatrists were less likely to combine medication treatment with psychotherapy (P < 0.05), and more likely to advise families to secretly administer medications in treatment refusal, such as in acute schizophrenia (P < 0.001) or major depression (P < 0.01).ConclusionsThese differences highlight the salience of local cultural context in the practice of psychiatry and in the treatment of Indian patients. Delhi psychiatrists are overwhelmed by the epidemic levels of untreated illness, spend less time with patients, and rely more heavily on medication treatment. Delhi psychiatrists employ unique approaches to handling difficult treatment issues, such as treatment refusal, intensive involvement of the family, and recommendations to the family about suitability for marriage for a patient.

A within-subject comparison of propofol and methohexital anesthesia for electroconvulsive therapy

Objectives The optimal anesthetic for electroconvulsive therapy (ECT) is a frequently studied but unresolved issue. Methohexital and propofol are 2 widely used anesthetic agents for ECT. The purpose of this study was to determine which of the 2 agents was associated with superior clinical outcomes. Methods Records from all patients who had undergone separate ECT courses with methohexital and propofol between 1992 and 2008 (n = 48) were reviewed for a retrospective within-subject comparison of outcome measures. The clinical outcomes we examined were number of treatments required in a course of ECT, changes in the Montgomery-Åsberg Depression Rating Scale and Mini Mental Status Examination, and length of stay in the hospital after initiation of ECT. Additionally, we compared treatment delivery between methohexital and propofol treatment courses, measuring rate of restimulation for brief seizures, seizure duration, percentage of treatments that were bilateral, and average charge administered. Results Data from 1314 treatments over 155 ECT courses were reviewed. Improvement in depressive symptoms, based on the Montgomery-Åsberg Depression Rating Scale, was not affected by choice of anesthetic agent. However, when right unilateral electrode placement was used, patients receiving propofol required significantly more treatments than those receiving methohexital. Propofol was also associated with a significantly higher requirement for bilateral ECT and higher stimulus dosing. Seizure duration was significantly shorter in the propofol condition, with more patients requiring restimulation for brief seizures. Length of stay in the hospital and cognitive outcomes were not significantly different between propofol and methohexital treatments. Conclusions We recommend methohexital as the induction agent of choice for ECT, especially with right unilateral placement.

What is the measure of a safe hospital? Medication errors missed by risk management, clinical staff, and surveyors.

Research in the last decade has identified medication errors as a more frequent cause of unintended harm than was previously thought. Inpatient medication errors and error-prone medication usage are detected internally by medication error reporting and externally through hospital licensing and accreditation surveys. A hospitals rate of medication errors is one of several measures of patient safety available to staff. However, prospective patients and other interested parties must rely upon licensing and accreditation scores, along with varying access to outcome data, as their sole measures of patient safety. We have previously reported that much higher rates of medication errors were found when an independent audit was used compared with rates determined by the usual process of self-report. In this study, we summarize these earlier findings and then compare the error detection sensitivity of licensing and accreditation surveys with that of an independent audit. When experienced surveyors fail to detect a highly error prone medication usage system, it raises questions about the validity of survey scores as a measure of safety (i.e., lack of medication errors). Replication of our findings in other hospital settings is needed. We also recommend measures for improving patient safety by reducing error rates and increasing error detection.

Identifying and reducing medication errors in psychiatry: creating a culture of safety through the use of an adverse event reporting mechanism.

Medication errors (MEs) in psychiatry have not been extensively studied. No long-term prospective efforts to demonstrate error reduction in psychiatric care using multidisciplinary interventions have been published in the literature. This article discusses the implementation of the Patient Safety Net (PSN) (an error reporting system) and of the Provider Order Entry (POE) program (a prescribing system). We educated and trained staff in their use, conducted concurrent chart reviews to estimate true error reduction, and provided continuous feedback as errors occurred. The intervention described here resulted in a reduction in MEs in association with performance improvement efforts that were conducted over 5 years and involved 65,466 patient days, and 617,524 billed doses, which is the largest study of an intervention to reduce psychiatric medication errors reported to date. (Journal of Psychiatric Practice. 2011;17:81–88).

Understanding clinician perception of common presentations in South Asians seeking mental health treatment and determining barriers and facilitators to treatment

BACKGROUND Little is known about the presentation of mental health symptoms among South Asians living in the US. OBJECTIVE To explore mental health symptom presentation in South Asians in the US and to identify facilitators and barriers to treatment. DESIGN Focus group study. PARTICIPANTS Four focus groups were conducted with 7-8 participants in each group. All participants (N = 29) were clinicians who had been involved in the care of South Asian patients with emotional problems and/or mental illness in the US. APPROACH Qualitative content analysis. RESULTS Key themes identified included: generational differences in symptom presentation, stress was the most common symptom for younger South Asians (<40 years of age), while major mental illnesses such as severe depression, psychosis and anxiety disorder were the primary symptoms for older South Asians (>40 years of age). Substance abuse and verbal/physical/sexual abuse were not uncommon but were often not reported spontaneously. Stigma and denial of mental illness were identified as major barriers to treatment. Facilitators for treatment included use of a medical model and conducting systematic but patient-centered evaluations. CONCLUSIONS South Asians living in the US present with a variety of mental health symptoms ranging from stress associated with acculturation to major mental illnesses. Facilitating the evaluation and treatment of South Asians with mental illness requires sensitivity to cultural issues and use of creative solutions to overcome barriers to treatment.

Decreasing adverse outcomes of unmodified electroconvulsive therapy: suggestions and possibilities.

Abstract Electroconvulsive therapy (ECT) is far and away the most effective treatment for depression and quite effective for a range of other psychiatric conditions that are unresponsive to medication. Electroconvulsive therapy in the developed world has been administered with anesthesia, muscle relaxants, and ventilation since the mid-1950s following 20 years of unmodified treatment. However, in much of the developing world, ECT continues to be administered unmodified because of lack of resources. We review the efficacy of unmodified compared with modified treatment. We also review the potential drawbacks of unmodified treatment including fear and anxiety, worse postictal confusion, fracture risk, and the negative effects of unmodified treatment on how ECT is perceived in the general community. Finally, we consider potential solutions in developing countries to minimize adverse outcomes of unmodified treatment by pretreating patients either with low-dose benzodiazepines or sedating, but not anesthetizing, dosages of anesthetic agents. Randomized controlled trials are necessary before either of these options could be considered an acceptable alternative to completely unmodified treatment when modified treatment is unavailable.

Safety considerations for outpatient electroconvulsive therapy.

As electroconvulsive therapy (ECT) requires general anesthesia and is associated with both cognitive and non-cognitive side effects, careful consideration must be given to the safety aspects of providing ECT on an outpatient basis. Drawing upon published literature and their clinical experience administering outpatient ECT, the authors propose best practices for safely providing ECT to outpatients. They review criteria for selecting patients for outpatient ECT as well as treatment and programmatic issues. The authors highlight the importance of educating referring clinicians as well as patients and their families about factors involved in the safe delivery of ECT for outpatients. Fiscal considerations and the drive toward reduced length of stay are prompting insurers and caregivers to choose outpatient over inpatient ECT. For each patient, such a choice merits a careful analysis of the risks of outpatient ECT, as well as the implementation of measures to ensure patient safety. (Journal of Psychiatric Practice 2012;18:130–136)

Perspectives on the use of eHealth in the management of patients with schizophrenia

Abstract Mobile devices, digital technologies, and web-based applications—known collectively as eHealth (electronic health)—could improve health care delivery for costly, chronic diseases such as schizophrenia. Pharmacologic and psychosocial therapies represent the primary treatment for individuals with schizophrenia; however, extensive resources are required to support adherence, facilitate continuity of care, and prevent relapse and its sequelae. This paper addresses the use of eHealth in the management of schizophrenia based on a roundtable discussion with a panel of experts, which included psychiatrists, a medical technology innovator, a mental health advocate, a family caregiver, a health policy maker, and a third-party payor. The expert panel discussed the uses, benefits, and limitations of emerging eHealth with the capability to integrate care and extend service accessibility, monitor patient status in real time, enhance medication adherence, and empower patients to take a more active role in managing their disease. In summary, to support this technological future, eHealth requires significant research regarding implementation, patient barriers, policy, and funding.

Overcoming cultural barriers to deliver comprehensive rural community mental health care in Southern India

AIM To describe obstacles overcome in establishing and implementing a comprehensive community psychiatry program in rural India. BACKGROUND Studies in low income countries point to a significant association of common mental disorders with female gender, low education, poverty, lack of access to running water in the home, and experiencing hunger. Gynecological complaints are associated with an increased risk of mental disorders. Suicide is a major public health problem with women outnumbering men in completed suicides in India. Among barriers to care are low value given to mental health by individuals in society, high prevalence of mental and neurological problems, apathy toward psychosocial aspects of health and development, and chronic lack of resources. DESIGN/METHODS We developed and implemented a program of care delivery thus (a) targeting the indigent women in the region; (b) integrating mental health care with primary care; (c) making care affordable and accessible; and (d) sustaining the program long term. I also review pertinent articles to demonstrate our success. RESULTS We provided mental healthcare for the indigent using a successful and vibrant model that overcame hurdles to treat patients from 187 villages in Southern India. Of note are low resource use, and the lack of accessibility, comprehensive care, the use of indigenous case workers and primary care professionals. CONCLUSIONS Rural mental health care must be culturally congruent, integrate primary care and local community workers for success.