Geir Langli

9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis

9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.

Regiochemistry in Stille couplings of 2,6-dihalopurines

Abstract The regiochemistry in Stille couplings of 2,6-dihalopurines have been studied. 2,6-Dichloropurines react selectively in the 6-position, and 6-chloro-2-iodopurines and 2-bromo-6-chloropurines in the 2-position.

Regioselective Pd-mediated coupling between 2,6-dichloropurines and organometallic reagents

Abstract Selective coupling in the purine 6-position has been achieved, by reacting N -benzylated 2,6-dichloropurines with organotin and organozinc reagents. The positional identity products were established from long range HETCOR or nOe NMR experiments.

Preparation of a Bridged Verbenindenyl Ligand for Metallocenes

Abstract The preparation of an annulated verbenyl indene is described. Reduction of the verbenone oxo group and water elimination provided a verbenylindene with an embedded fulvene unit, which was reduced to an annulated verbenylindene, a fluorene derivative. The ansa‐bridge was constructed between the fluorene 9‐position and 6,6‐dimethylfulvene by way of the lithiated indene. Dilithiation of the ligand and treatment with ZrCl4 yielded the corresponding zirconocene.