Geir Vegge
Lillehammer University College
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Featured researches published by Geir Vegge.
PLOS ONE | 2015
Håvard Nygaard; G. Slettaløkken; Geir Vegge; Ivana Hollan; Jon Elling Whist; Tor A. Strand; Bent R. Rønnestad; Stian Ellefsen
Purpose Irisin is a recently identified exercise-induced hormone that increases energy expenditure, at least in rodents. The main purpose of this study was to test the hypothesis that Irisin increases acutely in blood after singular sessions of intense endurance exercise (END) and heavy strength training (STR). Secondary, we wanted to explore the relationship between body composition and exercise-induced effects on irisin, and the effect of END and STR on muscular expression of the irisin gene FNDC5. Methods Nine moderately trained healthy subjects performed three test days using a randomized and standardized crossover design: one day with 60 minutes of END, one day with 60 minutes of STR, and one day without exercise (CON). Venous blood was sampled over a period of 24h on the exercise days. Results Both END and STR led to transient increases in irisin concentrations in blood, peaking immediately after END and one hour after STR, before gradually returning to baseline. Irisin responses to STR, but not END, showed a consistently strong negative correlation with proportions of lean body mass. Neither END nor STR affected expression of FNDC5, measured 4h after training sessions, though both protocols led to pronounced increases in PGC-1α expression, which is involved in transcriptional control of FNDC5. Conclusion The results strongly suggest that single sessions of intense endurance exercise and heavy strength training lead to transient increases in irisin concentrations in blood. This was not accompanied by increased FNDC5 expression, measured 4h post-exercise. The results suggest that irisin responses to resistance exercise are higher in individuals with lower proportions of lean body mass.
American Journal of Physiology-regulatory Integrative and Comparative Physiology | 2015
Stian Ellefsen; Daniel Hammarström; Tor A. Strand; Erika Zacharoff; Jon Elling Whist; Irene Rauk; Håvard Nygaard; Geir Vegge; Marita Hanestadhaugen; Mathias Wernbom; Kristoffer T. Cumming; Roar Rønning; Truls Raastad; Bent R. Rønnestad
Limited data exist on the efficacy of low-load blood flow-restricted strength training (BFR), as compared directly to heavy-load strength training (HST). Here, we show that 12 wk of twice-a-week unilateral BFR [30% of one repetition maximum (1RM) to exhaustion] and HST (6-10RM) of knee extensors provide similar increases in 1RM knee extension and cross-sectional area of distal parts of musculus quadriceps femoris in nine untrained women (age 22 ± 1 yr). The two protocols resulted in similar acute increases in serum levels of human growth hormone. On the cellular level, 12 wk of BFR and HST resulted in similar shifts in muscle fiber composition in musculus vastus lateralis, evident as increased MyHC2A proportions and decreased MyHC2X proportions. They also resulted in similar changes of the expression of 29 genes involved in skeletal muscle function, measured both in a rested state following 12 wk of training and subsequent to singular training sessions. Training had no effect on myonuclei proportions. Of particular interest, 1) gross adaptations to BFR and HST were greater in individuals with higher proportions of type 2 fibers, 2) both BFR and HST resulted in approximately four-fold increases in the expression of the novel exercise-responsive gene Syndecan-4, and 3) BFR provided lesser hypertrophy than HST in the proximal half of musculus quadriceps femoris and also in CSApeak, potentially being a consequence of pressure from the tourniquet utilized to achieve blood flow restriction. In conclusion, BFR and HST of knee extensors resulted in similar adaptations in functional, physiological, and cell biological parameters in untrained women.
Scandinavian Journal of Medicine & Science in Sports | 2014
Stian Ellefsen; Olav Vikmoen; Erika Zacharoff; I. Rauk; G. Slettaløkken; Daniel Hammarström; Tor A. Strand; Jon Elling Whist; M. Hanestadhaugen; Geir Vegge; Cathrine E. Fagernes; Håvard Nygaard; Ivana Hollan; Bent R. Rønnestad
Determination of muscle fiber composition in human skeletal muscle biopsies is often performed using immunohistochemistry, a method that tends to be both time consuming, technically challenging, and complicated by limited availability of tissue. Here, we introduce quantitative reverse transcriptase polymerase chain reaction (qRT‐PCR)‐based Gene‐family profiling (GeneFam) of myosin heavy chain (MyHC) mRNA expression as a high‐throughput, sensitive, and reliable alternative. We show that GeneFam and immunohistochemistry result in similar disclosures of alterations in muscle fiber composition in biopsies from musculus vastus lateralis and musculus biceps brachii of previously untrained young women after 12 weeks of progressive strength training. The adaptations were evident as (a) consistent increases in MyHC2A abundance; (b) consistent decreases in MyHC2X abundance; and (c) consistently stable MyHC1 abundance, and were not found using traditional reference gene‐based qRT‐PCR analyses. Furthermore, muscle fiber composition found using each of the two approaches was correlated with each other (r = 0.50, 0.74, and 0.78 for MyHC1, A, and X, respectively), suggesting that GeneFam may be suitable for ranking of individual muscle phenotype, particularly for MyHC2 fibers. In summary, GeneFam of MyHC mRNA resulted in reliable assessment of alterations in muscle fiber composition in skeletal muscle of previously untrained women after 12 weeks of strength training.
Journal of The International Society of Sports Nutrition | 2012
Geir Vegge; Bent R. Rønnestad; Stian Ellefsen
BackgroundThe effect on performance of protein ingestion during or after exercise is not clear. This has largely been attributed to the utilization of different scientific protocols and the neglection of accounting for factors such as differences in physical and chemical properties of protein supplements and differences in athletic performance level.MethodsWe hypothesized that ingestion of unprocessed whey protein (15.3 g·h-1) together with carbohydrate (60 g·h-1), would provide no ergogenic effect on 5-min mean-power performance following 120 min cycling at 50% of maximal aerobic power (2.8 ± 0.2 W·kg-1, corresponding to 60 ± 4% of VO2max), compared to CHO alone (60 g·h-1). Conversely, we hypothesized that ingestion of the hydrolyzed marine protein supplement NutriPeptin™ (Np, 2.7 g·h-1), a processed protein supplement with potentially beneficial amino acid composition, together with a PROCHO beverage (12.4 g·h-1 and 60 g·h-1, respectively) would provide an ergogenic effect on mean-power performance. We also hypothesized that the magnitude of the ergogenic effect of NpPROCHO would be dependent on athletic performance. As for the latter analysis, performance level was defined according to a performance factor, calculated from individual pre values of Wmax, VO2max and 5-min mean-power performance, wherein the performance of each subject was ranked relative to the superior cyclist whos performance was set to one. Twelve trained male cyclists (VO2max = 65 ± 4 ml·kg-1·min-1) participated in a randomized double-blinded cross-over study.Results and conclusionsOverall, no differences were found in 5-min mean-power performance between either of the beverages (CHO 5.4 ± 0.5 W·kg-1; PROCHO 5.3 ± 0.5 W·kg-1; NpPROCHO 5.4 ± 0.3 W·kg-1) (P = 0.29). A negative correlation was found between NpPROCHO mean-power performance and athletic performance level (using CHO-performance as reference; Pearson R = -0.74, P = 0.006). Moreover, ingestion of NpPROCHO resulted in improved 5-min mean-power performance relative to ingestion of CHO in the six lesser performing subjects compared to the six superior performing subjects (P < 0.05). This suggests that with the current protocol, NpPROCHO provided an ergogenic effect on 5-min mean-power performance in athletes with a lower performance level.
Journal of Sports Sciences | 2017
Bent R. Rønnestad; Joar Hansen; Geir Vegge; Iñigo Mujika
ABSTRACT Endurance athletes usually achieve performance peaks with 2–4 weeks of overload training followed by 1–3weeks of tapering. With a tight competition schedule, this may not be appropriate. This case investigates the effect of a 7-day overload period including daily high-intensity aerobic training followed by a 5-day step taper between two competitions in an elite cross-country mountain biker. Pre-test peak oxygen consumption was 89 ml·kg−1·min−1, peak aerobic power 6.8 W·kg−1, power output at 2 mmol·L−1 blood lactate concentration 3.9 W·kg−1, maximal isometric force 180 Nm and squat jump 21 cm. During overload, perceived leg well-being went from normal to very heavy. On day 1 after overload, vastus lateralis and vastus medialis EMGmean activity was reduced by 3% and 7%, respectively. Other baseline measurements were reduced by 3–7%. On day 4 of the taper, he felt that his legs were good and all measurements were 3–7% higher than before overload. On day 6 after the taper, his legs felt very good. This case shows that an elite mountain biker (11th in UCI World Cup one week prior to the pre-test) could achieve a rather large supercompensation by using a 12-day performance peaking protocol.
European Journal of Applied Physiology | 2014
Stian Ellefsen; Olav Vikmoen; G. Slettaløkken; Jon Elling Whist; Håvard Nygaard; Ivana Hollan; I. Rauk; Geir Vegge; Tor A. Strand; Truls Raastad; Bent R. Rønnestad
Scandinavian Journal of Medicine & Science in Sports | 2015
Bent R. Rønnestad; Joar Hansen; Geir Vegge; E. Tønnessen; G. Slettaløkken
International Journal of Sports Physiology and Performance | 2012
Ernst Albin Hansen; Bent R. Rønnestad; Geir Vegge; Truls Raastad
PubliCE Premium | 2017
Bent R. Rønnestad; Joar Hansen; Geir Vegge; Iñigo Mujika
PubliCE | 2017
Bent R. Rønnestad; Joar Hansen; Geir Vegge; Iñigo Mujika