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Gemma Victoria White

GlaxoSmithKline

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Publication

Featured researches published by Gemma Victoria White.

Bioorganic & Medicinal Chemistry Letters | 2010

Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.

Xianfeng Li; Yong-Kang Zhang; Yang Liu; Charles Z. Ding; Qun Li; Yasheen Zhou; Jacob J. Plattner; Stephen J. Baker; Xuelei Qian; Dazhong Fan; Liang Liao; Zhi-Jie Ni; Gemma Victoria White; Jackie E. Mordaunt; Linos Lazarides; Martin John Slater; Richard L. Jarvest; Pia Thommes; Malcolm Ellis; Colin M. Edge; Julia A. Hubbard; Don O. Somers; Paul Rowland; Pamela Nassau; Bill McDowell; Tadeusz Skarzynski; Wieslaw M. Kazmierski; Richard Martin Grimes; Lois L. Wright; Gary K. Smith

We have designed and synthesized a novel series of alpha-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position. These compounds are inhibitors of the HCV NS3 serine protease, and structural studies show that they inhibit the NS3 protease by trapping the Ser-139 hydroxyl group in the active site. Synthetic methodologies and SARs of this series of compounds are described.

Archive | 2007

2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS

Richard Martin Grimes; C.D. Hartley; Jacqueline Elizabeth Mordaunt; Pritom Shah; Martin John Slater; Gemma Victoria White

Archive | 2006

Antiviral 2-Carboxy-Thiophene Compounds

John Andrew Corfield; Richard Martin Grimes; David Harrison; Charles David Hartley; Peter D. Howes; Joelle Le; Malcolm Lees Meeson; Jacqueline Elizabeth Mordaunt; Pritom Shah; Martin John Slater; Gemma Victoria White

Archive | 2006

4-carboxy pyrazole derivatives as anti-viral agents

Gianpaolo Bravi; Anne Cheasty; John Andrew Corfield; Richard Martin Grimes; David Harrison; Charles David Hartley; Peter D. Howes; Katrina Jane Medhurst; Malcolm Lees Meeson; Jacqueline Elizabeth Mordaunt; Pritom Shah; Martin John Slater; Gemma Victoria White

Archive | 2008

Novel cyclic boronate inhibitors of hcv replication

Dazhong Fan; Richard L. Jarvest; Linos Lazarides; Qun Li; Xianfeng Li; Yang Liu; Liang Liao; Jacqueline Elizabeth Mordaunt; Zhi-Jie Ni; Jacob J. Plattner; Xuelei Qian; Martin John Slater; Gemma Victoria White; Yong Kang Zhang

Archive | 2014

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Niall Andrew Anderson; Deepak Bandyopadhyay; Alain Claude-Marie Daugan; Frédéric Donche; Patrick M. Eidam; Nicolas Eric Faucher; Nicolas S. George; Philip A. Harris; Jae U. Jeong; Bryan W. King; Clark A. Sehon; Gemma Victoria White; David D. Wisnoski

Archive | 2017

Compuestos de N-(2-(fenil) piridina-4-il)-5-morfolinopiridina-3-sulfonamida como inhibidores de la actividad PL3-quinasa

Anthony William James Cooper; Nicholas Paul Barton; Sebastien Andre Campos; Edward Paul Cannons; Kenneth David Down; Kevin James Doyle; Julie Nicole Hamblin; Graham George Adam Inglis; Armelle Le Gall; Vipulkumar Kantibhai Patel; Peace Simon; Sharpe Andrew; Gemma Victoria White; Niall Andrew Anderson

Archive | 2017

Chemical compounds as inhibitors of kinase activity

Niall Andrew Anderson; Nicholas Paul Barton; Sebastien Andre Campos; Edward Paul Cannons; Anthony William James Cooper; Kenneth David Down; Kevin James Doyle; Julie Nicole Hamblin; Graham George Adam Inglis; Gall Armelle Le; Vipulkumar Kantibhai Patel; Simon Peace; Andrew Sharpe; Gemma Victoria White

4th GSK/University of Strathclyde MPhil/PhD Symposium | 2014

Insight into improving the FBDD process

William Kerr; Gemma Victoria White

4th GSK/University of Strathclyde MPhil/PhD Symposium | 2014

Novel synthetic strategies to access borolane inhibitors of Lp-PLA2

William Kerr; Storm James Hart; Vipulkumar Kantibhai Patel; Gemma Victoria White

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Collaboration

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Martin John Slater

GlaxoSmithKline

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Jacqueline Elizabeth Mordaunt

GlaxoSmithKline

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Pritom Shah

GlaxoSmithKline

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Charles David Hartley

University of California

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Richard Martin Grimes

Research Triangle Park

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John Andrew Corfield

GlaxoSmithKline

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Niall Andrew Anderson

GlaxoSmithKline

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Vipulkumar Kantibhai Patel

GlaxoSmithKline

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William Kerr

University of Strathclyde

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Gianpaolo Bravi

University of California

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