Genadiy Kalayanov
Janssen Pharmaceutica
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Publication
Featured researches published by Genadiy Kalayanov.
Bioorganic & Medicinal Chemistry Letters | 2012
Christian Sund; Oscar Belda; Neera Borkakoti; Jimmy Lindberg; Dean Derbyshire; Lotta Vrang; Elizabeth Hamelink; Cathrine Åhgren; Esmeralda Woestenenk; Kristina Wikström; Anders Eneroth; Erik Lindström; Genadiy Kalayanov
A set of low molecular weight compounds containing a hydroxyethylamine (HEA) core structure with different prime side alkyl substituted 4,5,6,7-tetrahydrobenzazoles and one 4,5,6,7-tetrahydropyridinoazole was synthesized. Striking differences were observed on potencies in the BACE-1 enzymatic and cellular assays depending on the nature of the heteroatoms in the bicyclic ring, from the low active compound 4 to inhibitor 6, displaying BACE-1 IC(50) values of 44 nM (enzyme assay) and 65 nM (cell-based assay).
Journal of Medicinal Chemistry | 2009
David W. Smith; Genadiy Kalayanov; Christian Sund; Anna Winqvist; T. V. Maltseva; Vincent Leveque; Sonal Rajyaguru; Sophie Le Pogam; Isabel Najera; Kurt Benkestock; Xiao-Xiong Zhou; Ann C. Kaiser; Hans Maag; Nick Cammack; Joseph Armstrong Martin; Steven Swallow; Nils Gunnar Johansson; Klaus Klumpp; Mark A. Smith
Journal of Medicinal Chemistry | 2009
David W. Smith; Genadiy Kalayanov; Christian Sund; Anna Winqvist; Pedro Pinho; T. V. Maltseva; Veronique Morisson; Vincent Leveque; Sonal Rajyaguru; Sophie Le Pogam; Isabel Najera; Kurt Benkestock; Xiao-Xiong Zhou; Hans Maag; Nick Cammack; Joseph Armstrong Martin; Steven Swallow; Nils Gunnar Johansson; Klaus Klumpp; Mark A. Smith
Archive | 2016
Genadiy Kalayanov; Staffan Torssell; Horst Wähling
Bioorganic & Medicinal Chemistry Letters | 2012
Magnus Nilsson; Genadiy Kalayanov; Anna Winqvist; Pedro Pinho; Christian Sund; X. Zhou; Horst Wähling; Anna Karin Belfrage; Michael Pelcman; Tatiana Agback; Kurt Benckestock; Kristina Wikström; Mirva Boothee; Anneli Lindqvist; Christina Rydegård; Tim H. M. Jonckers; Koen Vandyck; Pierre Raboisson; Tse-I Lin; Sophie Lachau-Durand; Herman de Kock; David Bernard Smith; Joseph A. Martin; Klaus Klumpp; Kenneth Alan Simmen; Lotta Vrang; Ylva Terelius; Bertil Samuelsson; Åsa Rosenquist; Nils Gunnar Johansson
Archive | 2007
Nils-Gunnar Johansson; Genadiy Kalayanov; Joseph Armstrong Martin; David Bernard Smith; Anna Winqvist
Bioorganic & Medicinal Chemistry Letters | 2013
Bart Kesteleyn; Katie Amssoms; Wim Schepens; Geerwin Hache; Wim Gaston Verschueren; Wim Van De Vreken; Klara Rombauts; Greet Meurs; Patrick Sterkens; Bart Stoops; Lieven Baert; Nigel Austin; Jörg Wegner; Chantal Masungi; Inge Dierynck; Stina Lundgren; Daniel Jönsson; Kevin Edward Burdon Parkes; Genadiy Kalayanov; Hans Wallberg; Åsa Rosenquist; Bertil Samuelsson; Kristof Van Emelen; Jan-Willem Thuring
Bioorganic & Medicinal Chemistry Letters | 2017
Pedro Pinho; Genadiy Kalayanov; Hans Westerlind; Åsa Rosenquist; Horst Wähling; Christian Sund; Maria Rosário Almeida; Susana Ayesa; Jan Tejbrant; Paul Targett-Adams; Anders Eneroth; Annelie Lindqvist
Archive | 2014
Genadiy Kalayanov; Pedro Pinho; Hans Westerlind; Daniel Wiktelius; Horst Wähling
Archive | 2012
Magnus Nilsson; Genadiy Kalayanov; Anna Winqvist; Pedro Pinho; Christian Sund; Xiao-Xiong Zhou; Horst Wähling; Anna-Karin Belfrage; Michael Pelcman; Tatiana Agback; Kurt Benckestock; Kristina Wikström; Mirva Boothee; Anneli Lindqvist; Christina Rydegård; Koen Vandyck; Pierre Jean-Marie Bernard Raboisson; Tse-I Lin; Sophie Lachau-Durand; Herman de Kock; David Bernard Smith; Joseph Armstrong Martin; Klaus Klumpp; Kenneth Alan Simmen; Lotta Vrang; Ylva Terelius; Bertil Samuelsson; Åsa Rosenquist; Nils Gunnar Johansson
