George A. Boswell

Singlet oxygen oxidation of pyrroles: Synthesis and chemical transformations of novel 4,4-bis(trifluoromethyl)imidazoline analogs

Abstract A novel singlet oxygen ring cleavage of pyrrole 5a and subsequent acid-catalyzed facile dehydrocyclization afforded a new series of 4,4-bis(trifluoromethyl)imidazolines with a p-fluorophenacyl side chain at the 5-position, which have shown potent acyl CoA: cholesterol acyltransferase (ACAT) and cholesterol biosynthesis inhibitory activities.

Cyclobutanone analogs of β-lactam antibiotics: sythesis of n-acetyldeazathienamycin

Cyclobutanone analogs of thienamycin, including N-acetyldeazathienamycin, have been synthesized and their chemical and biological properties studied.

A FACILE SYNTHESIS OF FLUORINATED 4-HYDROXYCOUMARINS

Abstract Fluorinated 4-hydroxycoumarins were prepared from readily available fluorinated phenols via a AlCl 3 catalyzed Friedel-Crafts ring closure and followed by sequential one pot decarboxylation and deacetylation with 90% H 2 SO 4 .

Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors

Abstract An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis.