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George Balanikas

National Institutes of Health

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Featured researches published by George Balanikas.

Cancer Letters | 1985

Mutagenicity and tumor initiating activity of methylated benzo [k] fluoranthenes

Shantu Amin; Nalband Hussain; George Balanikas; Keith Huie; Stephen S. Hecht

The mutagenic activities toward Salmonella typhimurium TA100 and tumor initiating activities on mouse skin of the polynuclear aromatic hydrocarbons benzo[k]fluoranthene (BkF),2-methylBkF,8-methylBkF,9-methyl-BkF and 7,12-dimethylBkF were compared. BkF and 2-methylBkF were the most mutagenic of the compounds tested and had comparable activity; they were more active than 7,12-dimethylBkF. 8-MethylBkF and 9-methylBkF were not mutagenic. BkF and the methylated BkFs had similar tumor initiating activities on mouse skin. The results suggest that 8,9-dihydro-8,9-epoxy-BkF might be involved in the metabolic activation of BkF to a mutagen, but do not indicate which metabolite may be involved in BkF tumorigenesis.

Journal of Organic Chemistry | 1988

Oxidation of polynuclear aromatic hydrocarbons with ceric ammonium sulfate: preparation of quinones and lactones

George Balanikas; Nalband Hussain; Shantu Amin; Stephen S. Hecht

Cancer Research | 1987

High Stereoselectivity in Mouse Skin Metabolic Activation of Methylchrysenes to Tumorigenic Dihydrodiols

Shantu Amin; Keith Huie; George Balanikas; Stephen S. Hecht; John Pataki; Ronald G. Harvey

Journal of Organic Chemistry | 1986

Synthesis of potential phenolic metabolites of benzo[b]fluoranthene

Shantu Amin; Keith Huie; Nalband Hussain; George Balanikas; Steven G. Carmella; Stephen S. Hecht

Journal of Organic Chemistry | 1985

Synthesis and fluorescence spectra of structural analogues of potential benzo[b]fluoranthene-DNA adducts

Shantu Amin; George Balanikas; Keith Huie; Nalband Hussain; J.Edgar Geddie; Stephen S. Hecht

Carcinogenesis | 1988

Synthesis and mutagenicity of 5-alkyl-substituted chrysene-1,2-diol-3,4-epoxides

Shantu Amin; Keith Huie; George Balanikas; Stephen S. Hecht

Journal of Organic Chemistry | 1985

Synthesis of Methylated Benzo[b]fluoranthenes and Benzo[k]fluoranthenes

Shantu Amin; Keith Huie; Nalband Hussain; George Balanikas; Stephen S. Hecht

Chemical Research in Toxicology | 1988

Synthesis and tumor-initiating activities of dimethylchrysenes.

Shantu Amin; George Balanikas; Keith Huie; Stephen S. Hecht

Journal of Organic Chemistry | 1983

Preparation and stereochemistry of methylation of some cycloalkyl sulfones

Irvin Rothberg; Boby Sundoro; George Balanikas; Sheldon Kirsch

ChemInform | 1986

A Study of Chemical Carcinogenesis. Part 84. Synthesis and Fluorescence Spectra of Structural Analogues of Potential Benzo[b]fluoroanthene-DNA Adducts.

S. Amin; George Balanikas; Keith Huie; Nalband Hussain; J. E. Geddie; Stephen S. Hecht

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Stephen S. Hecht

University of Minnesota

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Keith Huie

National Institutes of Health

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Shantu Amin

Penn State Cancer Institute

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S. Amin

National Institutes of Health

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Carmella Sg

University of Minnesota

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J.Edgar Geddie

National Institutes of Health

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John Pataki

University of Chicago

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Ronald G. Harvey

University of Chicago

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Steven G. Carmella

University of Minnesota

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