George E. Meinken

Tin-117M-labeled stannic (SN4+) chelates

The radiopharmaceutical reagents of this invention and the class of Tin-117m radiopharmaceuticals are therapeutic and diagnostic agents that incorporate gamma-emitting nuclides that localize in bone after intravenous injection in mammals (mice, rats, dogs, and rabbits). Images reflecting bone structure or function can then be obtained by a scintillation camera that detects the distribution of ionizing radiation emitted by the radioactive agent. Tin-117m-labeled chelates of stannic tin localize almost exclusively in cortical bone. Upon intravenous injection of the reagent, the preferred chelates are phosphonate compounds, preferable, PYP, MDP, EHDP, and DTPA. This class of reagents is therapeutically and diagnostically useful in skeletal scintigraphy and for the radiotherapy of bone tumors and other disorders.

High-Specific-Activity 99mTc Human Serum Albumin

The authors describe a method of preparing high-specific-activity 99mTc HSA for use in cisternography and preparation of macroaggregates by adding 25 mg HSA, pertechnetate, and buffer to stannous chloride solution. The 99mTc HSA yield is >95%, as determined by gel chromatography.

High-specific-activity 99m Tc Human serum albumin.

The authors describe a method of preparing high-specific-activity 99mTc HSA for use in cisternography and preparation of macroaggregates by adding 25 mg HSA, pertechnetate, and buffer to stannous chloride solution. The 99mTc HSA yield is >95%, as determined by gel chromatography.