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Dive into the research topics where George Hartofilakidis is active.

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Featured researches published by George Hartofilakidis.


Journal of Bone and Joint Surgery, American Volume | 1996

Congenital Hip Disease in Adults. Classification of Acetabular Deficiencies and Operative Treatment with Acetabuloplasty Combined with Total Hip Arthroplasty

George Hartofilakidis; Konstantinos Stamos; Theofilos Karachalios; Theologos T Ioannidis; Nikolaos Zacharakis

We describe three distinct types of congenital hip disease in adults. The first type is dysplasia, in which the femoral head is contained within the original true acetabulum. The second type is low dislocation, in which the femoral head articulates with a false acetabulum, the inferior lip of which contacts or overlaps the superior lip of the true acetabulum, giving the appearance of two overlapping acetabula. The third type is high dislocation, in which the femoral head has migrated superoposteriorly and there is no contact between the true and the false acetabulum. We describe and classify the acetabular abnormalities and deficiencies found with these three types. If the anterior, posterior, and superior aspects of the acetabular component cannot be covered during a total hip arthroplasty because of a deficient acetabulum in an adult who has congenital hip disease, we advocate an acetabuloplasty technique (which we have named a cotyloplasty) that involves medial advancement of the acetabular floor by the creation of a controlled comminuted fracture of its medial wall, autogenous bone-grafting, and the implantation of a small acetabular component with cement. This procedure was performed in sixty-six patients (eighty-six hips). Forty-nine of the hips had a high dislocation, thirty-one had a low dislocation, and six were dysplastic. Two to fifteen years (mean, seven years) after the operation, the clinical and radiographic results were satisfactory. Only two acetabular components needed to be revised for aseptic loosening, at 5.3 and 7.5 years postoperatively. Moreover, the cumulative success rate for the acetabular components was 100 per cent at five years and 93.2 per cent at ten years.


Journal of Bone and Joint Surgery, American Volume | 2004

Total Hip Arthroplasty for Congenital Hip Disease

George Hartofilakidis; Theofilos Karachalios

BACKGROUND It is generally agreed that the clinical and radiographic results of total hip replacement performed for degenerative arthritis secondary to congenital hip disease vary depending on the severity of the anatomical abnormality. In this study, we report the mid-term and long-term clinical and radiographic results of total hip arthroplasty performed for each of the three different types of congenital hip disease. METHODS Between 1976 and 1994, the senior author performed 229 consecutive primary total hip arthroplasties in 168 patients with osteoarthritis secondary to congenital hip disease. Seventy-six hips were dysplastic, sixty-nine had a low dislocation, and eighty-four had a high dislocation. The Charnley low-friction technique was performed in 178 hips, and the so-called hybrid technique was performed in forty-six hips. Cementless arthroplasty was used in only five hips. RESULTS After a minimum of seven years of follow-up, the rates of revision of the acetabular components were 15% in the dysplastic hips, 21% in the hips with a low dislocation, and 14% in those with a high dislocation. The rates of revision of the femoral components were 14%, 14%, and 16%, respectively. Survivorship analysis predicted an overall rate of prosthetic survival at fifteen years of 88.8% +/- 4.8% in the dysplastic hips, 73.9% +/- 7.2% in the hips with a low dislocation, and 76.4% +/- 8.1% in those with a high dislocation. CONCLUSIONS An understanding of the anatomical abnormalities and the use of appropriate techniques and implants make total hip arthroplasty feasible for treatment of the three types of congenital hip disease. In patients with a low dislocation, the major technical problem is reconstruction of the natural acetabulum. In those with a high dislocation, the challenge is to place the acetabular component inside the reconstructed true acetabulum and to use an appropriate femoral implant in the hypoplastic narrow femoral diaphysis.


Journal of Bone and Joint Surgery-british Volume | 1988

Low friction arthroplasty for old untreated congenital dislocation of the hip

George Hartofilakidis; K Stamos; Tt Ioannidis

We report the replacement of 42 hips in 34 adults with untreated congenital dislocation. We used Charnley low friction implants, cementing the cup at the level of the true acetabulum after deepening and enlarging it by our own technique of cotyloplasty. Results were evaluated in 38 hips after a mean of 5.5 years. All the patients showed marked improvement, with no infection and, as yet, no late revision. The technical difficulties of the operation and the complications are discussed.


Journal of Bone and Joint Surgery-british Volume | 2011

An examination of the association between different morphotypes of femoroacetabular impingement in asymptomatic subjects and the development of osteoarthritis of the hip

George Hartofilakidis; N. V. Bardakos; George C. Babis; G. Georgiades

We retrospectively examined the long-term outcome of 96 asymptomatic hips in 96 patients with a mean age of 49.3 years (16 to 65) who had radiological evidence of femoroacetabular impingement. When surveillance commenced there were 17, 34, and 45 hips with cam, pincer, and mixed impingement, respectively. Overall, 79 hips (82.3%) remained free of osteoarthritis for a mean of 18.5 years (10 to 40). In contrast, 17 hips (17.7%) developed osteoarthritis at a mean of 12 years (2 to 28). No statistically significant difference was found in the rates of development of osteoarthritis among the three groups (p = 0.43). Regression analysis showed that only the presence of idiopathic osteoarthritis of the contralateral diseased hip was predictive of development of osteoarthritis on the asymptomatic side (p = 0.039). We conclude that a substantial proportion of hips with femoroacetabular impingement may not develop osteoarthritis in the long-term. Accordingly, in the absence of symptoms, prophylactic surgical treatment is not warranted.


Journal of Bone and Joint Surgery-british Volume | 2010

Congenital hip disease in adults

Theofilos Karachalios; George Hartofilakidis

This paper reviews the current knowledge relating to the management of adult patients with congenital hip disease. Orthopaedic surgeons who treat these patients with a total hip replacement should be familiar with the arguments concerning its terminology, be able to recognise the different anatomical abnormalities and to undertake thorough pre-operative planning in order to replace the hip using an appropriate surgical technique and the correct implants and be able to anticipate the clinical outcome and the complications.


Journal of Bone and Joint Surgery, American Volume | 1998

Treatment of High Dislocation of the Hip in Adults with Total Hip Arthroplasty. Operative Technique and Long-Term Clinical Results*

George Hartofilakidis; Konstantinos Stamos; Theofilos Karachalios

The clinical results of eighty-four total hip arthroplasties performed through a transtrochanteric approach in sixty-seven patients who had a high dislocation of the hip (the femoral head completely out of the acetabulum), from 1976 to 1994, were reviewed. The acetabular component was placed in the true acetabulum and the femur was shortened at the level of the femoral neck, along with release of the psoas tendon and the small external rotators, in order to facilitate reduction of the components and to avoid neurovascular complications. Eleven hip prostheses (13 per cent) failed at a mean of 6.4 years (range, two months to sixteen years) postoperatively; the failure was due to aseptic loosening of both components in four hips, aseptic loosening of the stem only in three, late infection in three, and malpositioning of the acetabular component that caused recurrent dislocations in one. The other seventy-three hips were functioning well at the latest follow-up examination, two to twenty years (mean, 7.1 years) postoperatively. The overall cumulative rate of success was 92.4 per cent (95 per cent confidence interval, 89.5 to 95.3 per cent) at five years and 88.0 per cent (95 per cent confidence interval, 82.2 to 93.8 per cent) at ten years. We believe that this operative technique of total hip arthroplasty is effective for the treatment of the difficult condition of high dislocation of the hip.


Orthopedics | 2000

Epidemiology, demographics, and natural history of congenital hip disease in adults.

George Hartofilakidis; Theofilos Karachalios; Konstantinos Stamos

This study examined the epidemiology and demographics of congenital hip disease in 468 (660 hips) patients who were examined between 1970 and 1996. In 356 (54%) hips, the diagnosis was secondary osteoarthritis due to congenital hip disease, and in 272 (41%) hips, the diagnosis was idiopathic osteoarthritis. In the remaining 32 (5%) hips, the diagnosis was uncertain. Of the hips with congenital hip disease, 170 (47.7%) hips were dysplastic, 85 (23.9%) had low dislocation, and 101 (28.4%) high dislocation. The majority of patients with congenital hip disease were women (338 [95%] hips). The natural history of the three types of congenital hip disease was studied in 157 patients (202 hips: 102 dysplastic, 42 low dislocation, and 58 high dislocation) who had received no treatment before the initial examination. Average length of follow-up was 17 years. In dysplastic hips, the disease remained undiagnosed until the onset of symptoms at an average age of 34.5 years. In patients with low dislocation, pain had started at an average of 32.5 years due to progressive degenerative arthritis within the false acetabulum. In patients with high dislocation, in the presence of a false acetabulum, pain started at an average age of 31.2 years, while in its absence, pain started at an average age of 46.4 years due to muscle fatigue. These findings suggest dysplasia, low dislocation, and high dislocation in adults are the results of untreated dysplasia, subluxation, and complete dislocation in infancy, respectively.


Clinical Orthopaedics and Related Research | 1993

A 12- to 18-year radiographic follow-up study of Charnley low-friction arthroplasty : the role of the center of rotation

Theofilos Karachalios; George Hartofilakidis; Nikolaos Zacharakis; Memi Tsekoura

In a 12- to 18-year radiographic follow-up study of 95 Charnley low-friction total hip arthroplasties (THA), there was a statistically significant correlation between location of the center of rotation of the total hip prosthesis (notably the element horizontal distance cup to tear-drop) and long-term, unfavorable, radiographic signs, such as acetabular and stem demarcation, cup wear, cup migration, subsidence of the stem, and calcar resorption. Small differences, as little as 2 mm, in the placement of the cup in relation to anatomic landmarks were responsible for these findings. A logistical regression analysis showed that the horizontal distance cup to teardrop was the most significant parameter influencing long-term unfavorable radiographic signs of a THA in comparison with the parameters of age, gender, diagnosis, and body-weight.


Journal of Arthroplasty | 2010

Effect of Cementless Acetabular Component Orientation, Position, and Containment in Total Hip Arthroplasty for Congenital Hip Disease

George Georgiades; George C. Babis; Georgia Kourlaba; George Hartofilakidis

We evaluated the effect of the inclination angle, position, and containment of 53 cementless cups inserted in patients with congenital hip disease (CHD), after a minimum of 10 years of follow-up. The polyethylene wear rate was significantly greater when the cup was placed in more than 45° inclination (P=.045) or if the cup was placed lateral to the teardrop position by more than 25 mm (P=.001). Aseptic loosening of the femoral component was significantly greater when the cup was placed more than 25 mm superiorly to the teardrop (P=.049). Cup placement of more than 25 mm lateral to the teardrop affected significantly periacetabular osteolysis (P=.032). In CHD cases, it is preferable to avoid excessive vertical inclination, lateral, and superior placement of cementless cups in an attempt to obtain better containment.


Clinical Orthopaedics and Related Research | 2008

The Morphologic Variations of Low and High Hip Dislocation

George Hartofilakidis; Christos K. Yiannakopoulos; George C. Babis

AbstractThree different types of congenital hip disease in adults have been distinguished based upon the position of the femoral head relative to the acetabulum and the underlying pathoanatomy of the joint: (1) dysplasia; (2) low dislocation; and (3) high dislocation. To facilitate classification of borderline or ambiguous cases, we studied the morphologic variations of low and high dislocation as observed on the radiographs of 101 hips with low and 74 hips with high dislocation. In low dislocation, 54 hips (53.5%) had extended coverage of the true acetabulum (Type B1) and 47 hips (46.5%) had limited coverage (Type B2). Among the cases with high dislocation, a false acetabulum with an adjacent femoral head occurred in 46 hips (62.2%) (Type C1), and the femoral head was floating within the gluteal muscles in 28 hips (37.8%) (Type C2). The kappa value for interobserver agreement between two raters who made radiographic measurements was 0.963, and for intraobserver agreement between the two evaluations of the same observer it was 0.946 and 0.971, respectively. The two types of low and high dislocation were associated with high intra- and interobserver agreement. Whether these distinctions have clinical utility requires further validation. Level of Evidence: Level III, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence.

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Kalliopi Lampropoulou-Adamidou

National and Kapodistrian University of Athens

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George C. Babis

National and Kapodistrian University of Athens

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John Vlamis

National and Kapodistrian University of Athens

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Konstantinos Stamos

National and Kapodistrian University of Athens

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Christos K. Yiannakopoulos

National and Kapodistrian University of Athens

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Georgia Kourlaba

National and Kapodistrian University of Athens

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Theologos T Ioannidis

National and Kapodistrian University of Athens

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E.A. Magnissalis

National and Kapodistrian University of Athens

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