George J. Armelagos

Paleopathology at the Origins of Agriculture

In 1982, the Conference on Paleopathology and Socioeconomic Change at the Origins of Agriculture was held in Plattsburgh, New York, to examine previously untested theories about how the adoption of agriculture had impacted human health. The collection of those conference proceedings transformed into this landmark book that set the standard for how to collect, analyse, and interpret osteological data in the study of health transitions. Using skeletal pathologies, the contributors examine how the transition from foraging to farming affected human health and nutrition. Now back in print and for the first time in paperback, Paleopathology at the Origins of Agriculture is a foundational piece in bioarchaeological literature and a central source of information regarding the impact of early farming on socioeconomic evolution. It remains a highly cited reference for archaeologists and physical anthropologists. Contributors present data from nineteen different regions before, during, and after agricultural transitions, analysing populations in Africa, Asia, the Middle East, Europe, and South America while primarily focusing on North America. A wide range of health indicators are discussed, including mortality, episodic stress, physical trauma, degenerative bone conditions, isotopes, and dental pathology.

Part Two: The role of constitutional factors, diet, and infectious disease in the etiology of porotic hyperostosis and periosteal reactions in prehistoric infants and children

Abstract A model of analysis incorporating methodological improvements and epidemiological refinements has been employed to investigate the etiology of porotic hyperostosis and periosteal reactions in infants and children from the Libben Site, a Late Woodland ossuary and occupation site from Ottawa County, Ohio. Results of the age-specific intrapopulational analysis of porotic hyperostosis demonstrate that the skeletal lesion strongly fits the age-specific distribution of hypochromic microcytic iron-deficiency anemia in infants and children. The data indicate that the lesion is a response to nutritional stress. Similarly, our findings show that the age-specific distribution of periosteal reactions strongly coincides with, and appears to be a response to, infectious disease as it occurs in infants and children. More importantly, survivorship and growth data indicate that porotic hyperostosis and periosteal reactions are strongly associated with patterns of infant and child morbidity and mortality, and therefore appear to play an important role in selection and fitness at Libben. Based upon the age-specific patterns and associations observed for porotic hyperostosis and periosteal reactions in the Libben infants and children, it is suggested that: 1. the current methodological procedure of partitioning skeletal populations into broad age categories can significantly distort important age-specific pathophysiological relationships; 2. skeletal lesions should be classified according to their physical quality (i.e., remodeled and unremodeled) to provide an estimate of both the morbidity and mortality associated with the age-specific distribution of a particular skeletal lesion; 3. porotic hyperostosis may be a valuable indicator of nutritional stress which can be employed to evaluate the nutritional status of prehistoric human populations; 4. the pathogenesis of porotic hyperostosis can best be understood in terms of the synergistic interactions between constitutional factors, diet, and infectious disease.

Nutritional Inference from Paleopathology

Publisher Summary This chapter reviews how patterns of skeletal growth and pathology can be used to investigate changing patterns of human interaction with the nutritional environment. Much of the effort in paleonutrition research has been directed toward the identification of dietary items. The realization that the skeletal pathologies of archaeological populations could aid in interpreting adaptation stimulated research in this area. The greatest drawback to the use of skeletal populations in nutritional studies is the generalized nature of their response to Stressors. Skeletal pathologies are most useful for archaeological reconstruction when a series of general and specific measures are analyzed for an entire skeletal population. In this way, both chronic and acute stress can be recognized, and the severity of each assessed. The future productivity of paleonutritional studies will require cooperation not only between anthropological subdisciplines, but between anthropology and a variety of other disciplines. Skeletal analysis, in particular, is increasingly oriented toward the techniques of chemistry and microbiology.

On the Origin of the Treponematoses: A Phylogenetic Approach

Background Since the first recorded epidemic of syphilis in 1495, controversy has surrounded the origins of the bacterium Treponema pallidum subsp. pallidum and its relationship to the pathogens responsible for the other treponemal diseases: yaws, endemic syphilis, and pinta. Some researchers have argued that the syphilis-causing bacterium, or its progenitor, was brought from the New World to Europe by Christopher Columbus and his men, while others maintain that the treponematoses, including syphilis, have a much longer history on the European continent. Methodology/Principal Findings We applied phylogenetics to this problem, using data from 21 genetic regions examined in 26 geographically disparate strains of pathogenic Treponema. Of all the strains examined, the venereal syphilis-causing strains originated most recently and were more closely related to yaws-causing strains from South America than to other non-venereal strains. Old World yaws-causing strains occupied a basal position on the tree, indicating that they arose first in human history, and a simian strain of T. pallidum was found to be indistinguishable from them. Conclusions/Significance Our results lend support to the Columbian theory of syphiliss origin while suggesting that the non-sexually transmitted subspecies arose earlier in the Old World. This study represents the first attempt to address the problem of the origin of syphilis using molecular genetics, as well as the first source of information regarding the genetic make-up of non-venereal strains from the Western hemisphere.

Apportionment of Racial Diversity: A Review

It has become increasingly popular to theorize and assert significant genetic differences between arbitrary regional, ethnic, and racial groupings of humans. Beginning with Livingstone, Brace, and Newman is the early 1960s, biological anthropologists have shown that variation in human traits is non‐concordant along racial lines, as they are products of overlapping, dynamic selective pressures.

The origins of agriculture: population growth during a period of declining health.

The increase in the Neolithic human population following the development of agriculture has been assumed to result from improvements in health and nutrition. Recent research demonstrates that this assumption is incorrect. With the development of sedentism and the intensification of agriculture, there is an increase in infectious disease and nutritional deficiencies particularly affecting infants and children.Declining health probably increased mortality among infants, children and oldest adults. However, the productive and reproductive core would have been able to respond to this increase in mortality by reducing birth spacing. That is, agricultural populations increased in size, despite higher mortality, because intervals between births became shorter.

Infant and childhood morbidity and mortality risks in archaeological populations.

Abstract Infants and children are nearly universally found to be among the most vulnerable subgroups of a population. Their health can be a sensitive indicator of the health of the population as a whole. Furthermore, repeated bouts of illness during infancy and childhood, periods of rapid development, can have lasting functional effects on the individual and the group. In this paper we provide a framework for studying infant and childhood health in archaeological populations, briefly review methods for studying infant‐childhood health in skeletal remains, and provide examples of the sensitivity and adaptive significance of this segment of the population by examining infant and childhood health at Dickson Mounds, Illinois and Wadi Haifa, Sudanese Nubia. A variety of methods are available for studying infant and childhood health in archaeological groups. Taken together, these methods can provide insights into the patterns and consequences of health in prehistory.

The Changing Disease-Scape in the Third Epidemiological Transition

The epidemiological transition model describes the changing relationship between humans and their diseases. The first transition occurred with the shift to agriculture about 10,000 YBP, resulting in a pattern of infectious and nutritional diseases still evident today. In the last two centuries, some populations have undergone a second transition, characterized by a decline in infectious disease and rise in degenerative disease. We are now in the throes of a third epidemiological transition, in which a resurgence of familiar infections is accompanied by an array of novel diseases, all of which have the potential to spread rapidly due to globalization.

Bone chemistry and past behavior: an overview

Human bone is a complex amalgam of compounds and chemicals—a variety of elements and isotopes—arranged in both organic and inorganic phases. In addition to the major components—calcium, phosphate and water—a number of minor and trace elements are also incorporated during the manufacture of bone tissue. These building materials are obtained by ingestion and the chemical composition of bone is thus in part a reflection of the local environment from which foods are obtained. Both isotopes and trace elements in prehistoric bone have been used to obtain information on human diet and the local environment. These new techniques are outlined here as a means for studying questions such as subsistence, status, and residence. Bone mineralization processes are also discussed as a means for the discovery of paleopathology and disease. Example applications are reviewed to document the potential of such techniques for the reconstruction of the past.

Factors Influencing the Etiology of Cribra Orbitalia in Prehistoric Nubia

Abstract The present research represents an attempt to explain the occurrence of cribra orbitalia in Nubian skeletal remains associated with Meroitic, X-Group and Christian cultural horizons. The distribution of cribra orbitalia among 285 crania examined revealed a concentration of lesions among infants and aged individuals. While earlier studies have suggested cribra orbitalia may reflect the occurrence of abnormal hemoglobins such as sickle cell anemia or thalassemia, a consideration of the environmental context in which the lesions occurred makes an alternative hypothesis more likely. Particularly in Nubia (past and present), where parasitic infection is high, the diet is poor in iron, weanling diarrhea is frequent and multiparity is the norm, chronic iron deficiency anemia is a more likely causal factor. This interpretation is also compatable with clinical observations of cribra orbitalia among modern individuals suffering from chronic iron deficiency anemia.