George K. Andrikopoulos

Lack of Association between Common Polymorphisms in Genes of the Renin-Angiotensin System and Mortality after Myocardial Infarction

The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C polymorphism in the AT1R gene have been associated with left ventricular remodelling and prognosis after acute myocardial infarction (AMI). We investigated whether these genetic variants associate with impaired left ventricular ejection fraction (LVEF) and increased risk for in-hospital mortality after AMI. Consecutive AMI patients were recruited on admission and were genotyped for the above-mentioned polymorphisms. The frequency of the studied genotypes did not differ significantly between deceased patients and those who survived. The LVEF did not differ among patients with or without the DD genotype (45 ± 10 vs. 45 ± 10%, p = 0.892) or the CC genotype (45 ± 10 vs. 46 ± 10%, p = 0.859). These data question the role of the studied genotypes in the pathogenesis of AMI and do not support the previously supported hypothesis that these genotypes influence prognosis after AMI.

Significance of QRS Duration Changes in the Evaluation of ST-Segment Depression Presenting Exclusively During the Postexercise Recovery Period

Background: The aim of this study was to evaluate the contribution of QRS prolongation in the diagnosis of coronary artery disease (CAD) in patients with exercise‐induced ST‐segment depression exclusively during the recovery period.

Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings.

Background: Heart rate recovery (HRR) has been identified as a reliable predictor of cardiac mortality, correlated with autonomic tone. In a model of sequential exercise testings, we investigated the reproducibility of HRR and the association between HRR modification and myocardial adaptation to ischemia.

Detection of Multivessel Disease Post Myocardial Infarction Using an Exercise‐Induced QRS Score

Objective:u2002The aim of this study was to investigate the ability of Athens QRS score values to detect stenoses in other coronary arteries than the obstructed ones (which caused the myocardial infarction [MI]) in patients with a history of MI.

Contents Vol. 135, 2016

D. Atar, Oslo H. Boudoulas, Columbus, Ohio J.A. Franciosa, New York, N.Y. I.J. Gelb, Boca Raton, Fla. D. Heistad, Iowa City, Iowa X. Huang, Boca Raton, Fla. J.T. Kassotis, Brooklyn, N.Y. J.M. Lazar, Brooklyn, N.Y. B.S. Lewis, Haifa A.B. Miller, Jacksonville, Fla. J.V. Nixon, Richmond, Va. D.J. Sahn, Portland, Oreg. A. Salemi, New York, N.Y. J. Somberg, Chicago, Ill. H. Taegtmeyer, Houston, Tex. International Journal of Cardiovascular Medicine, Surgery, Pathology and Pharmacology