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George S. K. Wong

Schering-Plough

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Publication

Featured researches published by George S. K. Wong.

Tetrahedron-asymmetry | 2002

The asymmetric synthesis of (3R)-N-methyl-2-oxo-[1,4′-bipiperidine]-3-acetamide in quantity

Gregory A. Reichard; James M. Spitler; Ingrid Mergelsberg; Alan Miller; George S. K. Wong; Ramani R. Raghavan; John K. Jenkins; Tong Gan; Andrew T. McPhail

Abstract The asymmetric synthesis of the enantiomerically pure bipiperidine core fragment of a potent dual NK 1 /NK 2 antagonist is described. The utilization of a diastereoselective Michael addition employing Evans’ auxiliary as the key step allowed for the preparation of the fragment on a multi-kilogram scale.

Journal of the American Chemical Society | 2012

Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization

Tao Li; Jack Liang; Alexandre Ambrogelly; Tim Brennan; Guy Gloor; Gjalt Huisman; James Lalonde; Azzeddine Lekhal; Ben Mijts; Sheela Muley; Lisa M. Newman; Matt Tobin; George S. K. Wong; Aleksey Zaks; Xiyun Zhang

Archive | 2004

Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof

Jeonghan Park; Anantha Sudhakar; George S. K. Wong; Minzhang Chen; Juergen Weber; Xiaojing Yang; Daw-long Kwok; Ingyu Jeon; Ramani R. Raghavan; Maria Tamarez; Weidong Tong; Eugene J. Vater

Organic Process Research & Development | 2003

Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug Intermediate

Maria Tamarez; Brian Morgan; George S. K. Wong; Weidong Tong; Frank Bennett; Raymond G. Lovey; Jinping Mccormick; Aleksey Zaks

Archive | 2004

Process and intermediates for the preparation of (1R,2S,5S)-3-azabicyclo[3,1,0]hexane-2-carboxamide, N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[1,1-dimethylethyl]amino]carbonylamino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl

Anantha Sudhakar; Vilas Radhika Nilayam IInd Floor Dahanukar; Ilia A. Zavialov; Cecilia A. Orr; Hoa N. Nguyen; Juergen Weber; Ingyu Jeon; Minzhang Chen; Michael D. Green; George S. K. Wong; Jeonghan Park; Tetsuo Iwama

Archive | 2010

PROCESS FOR THE PREPARATION OF 6,6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE COMPOUNDS AND ENANTIOMERIC SALTS THEREOF

George G. Wu; Frank Xing Chen; Paitoon Rashatasakhon; Jeffrey M. Eckert; George S. K. Wong; Hong-Chang Lee; Nolan C. Erickson; Jennifer Ann Vance; Peter C. Nirchio; Juergen Weber; David Jieh-Shyh Tsai; Nanfei Zou

Archive | 2007

PREPARATION OF 3-AMINO-3-(CYCLOBUTYLMETHYL)-2-(HYDROXY)-PROPIONAMIDE HYDROCHLORIDE

Jeonghan Park; Eugene J. Vater; Shuan Dong; Tetsuo Iwama; Ramani R. Raghavan; Hong-Chang Lee; George S. K. Wong

Archive | 2007

Process for preparing (1r,2s,5s)-n-[(1s)-3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2s)-2-[[[(1,1-dimethylethyl)amino]-carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide

George S. K. Wong; Hong-Chang Lee; Jennifer Ann Vance; Weidong Tong; Tetsuo Iwama

Organic Process Research & Development | 2011

The Safe Use of Sodium Hydride on Scale: The Process Development of a Chloropyrimidine Displacement

Jamie McCabe Dunn; Alicia Duran-Capece; Brendan Meehan; James Ulis; Tetsuo Iwama; Guy Gloor; George S. K. Wong; Evan Bekos

Archive | 2002

Synthesis of 4-[(z)-(4-bromophenyl)(ethoxyimino)methyl]-1'-[2,4-dimethyl-1-oxido-3-pyridinyl)carbonyl]-4'methyl-1,4'bipiperidine

Minzhang Chen; Bosco D'sa; William Leong; Tong Gan; George S. K. Wong; Suhan Tang; Christopher M. Nielsen

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Jeonghan Park

Schering-Plough

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Juergen Weber

Schering-Plough

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Minzhang Chen

Schering-Plough

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Anantha Sudhakar

Schering-Plough

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Ramani R. Raghavan

Schering-Plough

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Tetsuo Iwama

Schering-Plough

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Weidong Tong

Schering-Plough

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Ingyu Jeon

Merck

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Eugene J. Vater

Schering-Plough

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Hong-Chang Lee

Schering-Plough

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