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Dive into the research topics where George T. Lee is active.

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Featured researches published by George T. Lee.


Tetrahedron Letters | 2002

A facile synthesis of 2,4-diaza-1-borines from anilines

George T. Lee; Kapa Prasad; Oljan Repic

Abstract A general synthesis of diazaborines is described with the in situ preparation of amidines from anilines using a nitrile and AlCl3, followed by the addition of BCl3 and heating. The diazaborines were isolated as hydrochlorides in pure form and, in the case of 5 , the structure was confirmed by an X-ray analysis.


Synthetic Communications | 1995

A Practical Preparation of Methyl 4-(Trimethylsilyl)-benzoate: An Intermediate in the Synthesis of SDZ 63135

John C. Amedio; George T. Lee; Kapa Prasad; Oljan Repic

Abstract An improved synthesis of ester 1 is described utilizing a bromine-lithium exchange and a Grignard-mediated methoxy-carbonylation reaction starting from 1, 4-dibromobenzene. Compound 1 was converted to 2 through a condensation and dehydration sequence with an overall yield of 41.5%.


Archive | 2002

Heterocyclic compounds and methods of use

Andrew Bach; Prasad Koteswara Kapa; George T. Lee; Eric Loeser; Michael Lloyd Sabio; James Lawrence Stanton; Thalaththani Ralalage Vedananda


Organic Process Research & Development | 2004

Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of Fragment C7-24

Stuart J. Mickel; Gottfried Sedelmeier; Daniel Niederer; Friedrich Schuerch; Manuela Seger; Klaus Schreiner; Robert Daeffler; Adnan Osmani; Dominique Bixel; Olivier Loiseleur; Jacques Cercus; Hans Stettler; and Karl Schaer; Remo Gamboni; Andrew Bach; Guang-Pei Chen; Weichun Chen; Peng Geng; George T. Lee; Eric Loeser; Joseph McKenna; Frederick Ray Kinder; Kurt Königsberger; Kapa Prasad; Timothy Michael Ramsey; Noela Reel; Oljan Repic; Larry Rogers; Wen-Chung Shieh; Run-Ming Wang


Organic Process Research & Development | 2004

Large-scale synthesis of the anti-cancer marine natural product (+)-discodermolide. Part 3: Synthesis of fragment C15-21

Stuart J. Mickel; Gottfried Sedelmeier; Daniel Niederer; Friedrich Schuerch; Guido Koch; Ernst Kuesters; Robert Daeffler; Adnan Osmani; Manuela Seeger-Weibel; Emil Schmid; Alfred Hirni; Karl Schaer; Remo Gamboni; Andrew Bach; Stephen Chen; Weichun Chen; Peng Geng; Christopher Turchik Jagoe; Frederick Ray Kinder; George T. Lee; Joseph McKenna; Timothy Michael Ramsey; Oljan Repic; Larry Rogers; Wen-Chung Shieh; Run-Ming Wang; Liladhar Murlidhar Waykole


Archive | 1991

Processes for the synthesis of 3-disubstituted aminoacroleins

George T. Lee; Oljan Repic


Archive | 1992

Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes

George T. Lee; Prasad Koteswara Kapa; Oljan Repic


Advanced Synthesis & Catalysis | 2005

Pd-Catalyzed ortho-Selective Oxidative Coupling of Halogenated Acetanilides with Acrylates

George T. Lee; Xinglong Jiang; Kapa Prasad; Oljan Repic; Thomas J. Blacklock


Organic Process Research & Development | 2001

The Story of Lescol: From Research to Production†

Oljan Repic; and Kapa Prasad; George T. Lee


Organic Process Research & Development | 2003

An Expedient Synthesis of LAF389, a Bengamide B Analogue

David Xu; Liladhar Murlidhar Waykole; John Vincent Calienni; Lech Ciszewski; George T. Lee; Wenming Liu; Joanna Szewczyk; Kevin Vargas; Kapa Prasad; Oljan Repic; Thomas J. Blacklock

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