George W. Jones

Blood hormone profiles in prostate cancer patients in high‐risk and low‐risk populations

Epidemiologic data reveal that the incidence rate of prostate gland carcinoma among the black population in the United States (US) is several times higher than among Nigerians. A collaborative study between the two countries was undertaken, and blood hormone (testosterone [T], dihydrotestosterone [DHT], estrone [E1], estradiol [E2], and prolactin [P1]), total acid phosphatase (TP), and prostatic acid phosphatase (PAP) profiles in the two population groups were compared. In the US groups (patients and controls) there were significantly higher levels of T (P < 0.01) and E1 (P < 0.05) compared with the Nigerians. Also, the US patients had significantly higher levels of T (P < 0.05) and E1 (P < 0.01) compared with their matched controls. In the Nigerians T but not E1 levels were significantly lower (P < 0.05) in patients compared with controls. DHT, E2, and PI were not significantly different in patients and controls between and within the populations. Nigerian patients had higher levels (P < 0.001) of TP and PAP compared with US patients. It is concluded that differences in blood hormone profiles in the two population groups are based on factors other than the genetic makeup of the populations.

The role of diet in prostate cancer.

This is a one-to-one, age- and race-matched case-control study involving 55 histologically confirmed black prostate cancer patients and 55 controls who were seen at three major hospitals in Washington, DC from 1982 to 1984. Personal interviews were conducted to obtain the number of times food items of specified serving size were consumed per week by cases and controls; the subjects were grouped according to the age periods 30-49 and 50 years and older. We then calculated the average daily consumption of each of 18 nutrients per 1,000 calories. There was a significant negative association between linoleic acid (p less than 0.04) for the 50 years and older group, thiamin (p less than 0.05) for those 30-49 years old, riboflavin (p less than 0.03) for the 50 and older group, and iron (p less than 0.05) for those 30-49 years old. The results of this study suggest that the intake of thiamin and iron (in subjects 30-49 years old), linoleic acid and riboflavin (in subjects 50 years and over) could be protective because control subjects consumed more of these nutrients than did the cases.

Prospective, conservative management of localized prostate cancer.

Background. Currently, no randomized trials of the various treatment options for localized prostate cancer have been reported. Therefore, radical prostatectomy and external irradiation are offered as the primary management options and are thought by many to be curative.

Epidemiologic association between gonorrhea and prostatic carcinoma

The curves for death rates from prostatic cancer and gonorrhea incidence rates in Denmark, over a span of thirty years, matched well with a lag period of forty-five years. Moreover, a retrospective study conducted in the United States involving 75 cancer patients and 75 age-matched controls demonstrated a statistically significant association between gonorrheal infection and subsequent development of prostatic carcinoma. Two postulates are presented: the viral-venereal and the chronic infection theories. The recent increase in incidence of prostatic cancer in the United States could be the beginning of an epidemic in which astronomically high rates may be reached.

Renal angiomyolipoma associated with tuberous sclerosis: Review of the literature

Abstract A case of bilateral renal angiomyolipoma associated with tuberous sclerosis is presented. Although in our patient right renal biopsy specimen demonstrated angiomyoma, we believe that the lipomatous element could be found in a larger specimen. Roentgenographic and therapeutic considerations are presented and the different lesions of tuberous sclerosis reviewed. Unlike most patients exhibiting stigmata of tuberous sclerosis, our patient had normal mentality and seizures preceded skin lesions. Fundoscopic examination revealed retinal arteriolitis with an occlusive phenomenon which, to our knowledge, has not been reported previously.

Mixed mesodermal tumor of urinary bladder: A Light and Electron Microscopic Study☆

Light and ultrastructural findings in a mixed mesodermal tumor of the urinary bladder are reported. The mesenchymal component of the tumor contained undifferentiated mesenchymal cells and cells with chondroblastic differentiation. The neoplastic chondrocytes displayed an abundance of cytoplasmic microfilaments and had a scalloped cell surface.

Idiopathic renal arteriovenous fistula

Abstract A large and symptomatic idiopathic renal arteriovenous (AV) fistula closed over a two-year period of clinicoradiologic observation. This feature of idiopathic renal AV fistulas has not been eported previously, to our knowledge. If the presenting symptoms permit nonintervention, not only the trauma-related but also the idiopathic renal AV fistula can be conservatively managed and may heal spontaneously.

Diagnosis and management of prostate cancer

Representing 18% of male cancers, carcinoma of the prostate gland is the second most common cancer and the third leading cause of cancer deaths in US males. In 1982, it is estimated 73,000 new cases and 23,000 deaths will occur from the most common cancer in men older than 65 years of age. US blacks have the highest incidence in the world. Annual rectal digital examination of the prostate gland discovering a suspicious nodule or indurated area of the gland remains the earliest means of detection of the prostatic cancer in the asymptomatic man. However, more commonly the earliest unsuspected detection occurs in the surgical specimen removed following operations to relieve obstructive symptoms of benign prostatism. Survival of patients with this disease correlates with the stage and grade of disease at time of diagnosis, consequently it is imperative to ascertain the extent of disease in order to select the appropriate therapy for the patient. Radical prostatectomy, interstitial radiation implantation, and external radiation are the current means of treatment patients with low‐stage disease, while hormonal manipulation alone or in combination with external radiation and chemotherapy are the primary means of treatment symptomatic patients with carcinoma of the prostate. The expected five‐year survival for low‐stage disease is 70–80%.

Gonadal stromal tumor in black male

A twenty-five-year-old black male presented with a right testicular mass which had progressively increased in size over three years. He was in good health and noted no other general abnormalities. Taking all malignant precautions, excisional biopsy of the lesion revealed gonadal stromal tumor by frozen section. The testis was left in situ, and the patient has continued to remain asymptomatic.