Georges Ziade

Structural and Anatomic Laryngeal Measurements in Geriatric Population Using MRI

OBJECTIVE The study aims to evaluate the changes in volume and dimensions of the thyroarytenoid (TA) muscle in the elderly using magnetic resonance imaging (MRI). STUDY DESIGN This is a retrospective study. METHODS The neck MRIs of 40 adult patients aged less than 65 years old and 40 patients aged 65 years old and above were compared. Demographic data included age and gender. The length, width, and height of the TA muscle as well as its volume were measured on each side, right and left, in both groups. RESULTS The differences in the mean length, width, and height of TA muscle were not statistically significant between the two groups on either right or left side. Similarly, there was no statistically significant difference in the mean volume of the TA muscles between the two groups on either side as well. The mean volume of the right and left TA muscles in those aged less than 65 years was 0.65 ± 0.26 mL and 0.69 ± 0.30 mL, respectively. The mean volume of the right and left TA muscles in the elderly group was 0.72 ± 0.31 mL and 0.72 ± 0.32 mL, respectively. CONCLUSION Using MRI, there are no dimensional or volumetric changes in TA muscles with aging.

Transnasal Injection Laryngoplasty

Objectives: The objective of this study was to evaluate the role of transnasal fiber-optic injection laryngoplasty in the treatment of glottic insufficiency. Methods: Video recordings of 16 patients who underwent fiber-optic injection laryngoplasty for the treatment of glottic insufficiency were reviewed. Outcome measures included perceptual evaluation using the GRBAS (grading, roughness, breathiness, asthenia, straining) classification, laryngeal videostroboscopy, and frame-by-frame analysis to assess the extent, shape, and duration of glottic closure. Results: Nine patients were ultimately included in this study. Their mean age was 66.2 years, with 7 men and 2 women. The most common symptoms were dysphonia and aspiration, and the most common diagnosis was vocal fold paralysis. Patients underwent transnasal fiber-optic injection laryngoplasty with hyaluronic acid as a filling material (0.2-0.8 mL). The procedure was well tolerated by all patients, with improvement in the phonatory symptoms and aspiration in 66.66% and 50% of patients, respectively. There were significant decreases in the mean scores of all perceptual parameters (P < .05 for all). All subjects had glottal gap preoperatively that was closed completely in 66.66% and reduced to <2 mm in 33.33%. The mean closed quotient significantly increased from 0.10 to 0.51 (P < .05). Conclusions: Transnasal fiber-optic injection laryngoplasty is a safe procedure well tolerated by patients with good results.

Adaptation of the Arabic Version of the Tinnitus Handicap Inventory

Objective To translate the Tinnitus Handicap Inventory (THI) into literary Arabic to come up with a unified Arabic version and to determine its validity and reliability in assessing the quality of life of Arabic-speaking patients with tinnitus. Study Design Clinical measurement study. Setting Tertiary care center. Subjects and methods The original English THI was translated into literary Arabic by a forward- and back-translation process according to the published guidelines for cross-cultural adaptation of health-related quality-of-life measures and applied to 100 patients with chronic tinnitus. Internal consistency reliability was then assessed by calculating Cronbach’s alpha coefficient. Pearson correlation coefficients were also calculated for the different scales and the different baseline characteristics. Results Results showed high internal consistency and reliability coefficients (total THI: 0.93, functional subscale: 0.86, emotional subscale: 0.86, catastrophic subscale: 0.66) comparable to those of the original English THI. Conclusion The Arabic version of the THI is a valid and reliable tool for the assessment of the impact of tinnitus on the quality of life of Arabic-speaking patients with the complaint of chronic tinnitus.

Correlation Between the Position of the Hyoid Bone on Lateral Cephalographs and Formant Frequencies

OBJECTIVES The objective of this study is to examine the F1, F2, F3, and F4 during sustained vowels /ɑ/, /i/, /o/, /u/. STUDY DESIGN Prospective cross-sectional study. METHODS Fifty-two consecutive patients aged between 9 years and 38 years were invited to participate in this study. Linear measurements included linear vertical distance from the hyoid bone to the sella turcica (H-S); linear vertical distance from the hyoid bone to the posterior nasal spine (H-PNS); linear measure from the hyoid bone to the most anterior point of the cervical vertebra C3 (H-C3); and linear vertical distance from the hyoid bone to the mandibular plane (H-MP). RESULTS The results showed a moderate and statistically significant correlation between the average fundamental frequency for the vowel /ɑ/ and H-C3, H-S, and H-PNS and another moderate negative correlation between F3 and F4, and the vertical position of the hyoid bone H-C3 and H-S. For the vowel /i/, there was a moderate negative correlation between F1, F3, and F4 and H-S and also a moderate negative correlation between F3 and F4 and H-C3. For the vowel /o/, there was a moderate negative correlation between F4 and H-S and H-PNS. For the vowel /u/, only F4 correlated significantly with H-S. CONCLUSION There is a moderate correlation between the high formants, mostly F4, and the cephalo-caudal position of the hyoid bone.

Vocal Symptoms and Acoustic Findings in Menopausal Women in Comparison to Pre-menopause Women with Body Mass Index as a Confounding Variable

Objectives To compare the prevalence of phonatory symptoms in menopausal women compared to pre-menopause women with body mass index (BMI) as a confounding variable. Methods A total of 69 women, 34 menopausal and 35 pre-menopausal were invited to participate in this study. Demographic variables included age, smoking, and BMI. All subjects were asked about the presence hoarseness, loss of high or low frequencies, pitch breaks, throat clearing, dryness in the throat and vocal fatigue. Acoustic analysis was performed and the Voice Handicap Index (VHI)-10 was filled by all the subjects. Results There was a significantly higher prevalence of throat clearing and dryness in the menopausal group compared to the pre-menopause group with a P value of 0.035 and 0.032 respectively. When BMI was taken into account, there was no statistically significant difference in the prevalence of any of the phonatory symptoms in menopausal women with high BMI and pre-menopause. There was no statistically significant difference in the means of any of the acoustic parameters between the menopausal group and pre-menopausal group. There was no significant difference in the mean VHI-10 between the menopause group and the pre-menopause (P = 0.652). Conclusions The results of this investigation substantiate the importance of fat as an alternative source of estrogen which can mask some of the phonatory symptoms.

Effect of Rapid Maxillary Expansion on Voice.

OBJECTIVE The purpose of this investigation is to evaluate the effect of rapid maxillary expansion (RME) on the fundamental frequency (F0) and formant frequencies F1-F4. STUDY DESIGN Cross-sectional study. MATERIALS AND METHODS A total of 14 consecutive patients between the ages of 9.6 years and 15 years with a constricted maxilla undergoing RME were included in this study. Measurements were made before (T1) and after treatment (T2). These included maxillary arch length, depth, width, and perimeter in addition to F0, habitual pitch, and formants F1, F2, F3, and F4 for the vowels /ɑ/, /i/, /o/, and /u/. RESULTS There was a significant difference in the mean of F1/ɑ/ and F2/ɑ/ before and after treatment (P value of 0.04 and 0.013, respectively). It is worth noting that F1/ɑ/ decreased in 11 and F2/ɑ/ decreased in 10 of the 14 subjects. CONCLUSION The application of RME in the treatment of maxillary constriction leads to a significant lowering of the first and second formants for the vowel /ɑ/ in most subjects. Subjects undergoing rapid maxillary application should be aware of the potential change in voice quality especially in case of professional voice users.

Late pneumolabyrinth after stapedectomy.

INTRODUCTION Pneumolabyrinth is defined as the presence of air within the inner ear causing cochleovestibular signs and symptoms. Twenty-seven cases of pneumolabyrinth are published in the literature of which only two were described as delayed pneumolabyrinth as a complication of stapes surgery. CASE REPORT A 45-year-old male patient presented with vertigo after Valsalva maneuver 12 years after stapedectomy. He was diagnosed with delayed pneumolabyrinth on high resolution computed tomography and underwent an exploratory tympanotomy with surgical repair. DISCUSSION Delayed pneumolabyrinth is a rare complication of stapes surgery and should be considered in patients presenting with vestibulocochlear symptoms even many years later. An exploratory tympanotomy is recommended for patients diagnosed with pneumolabyrinth and having a sensorineural hearing loss and/or persistent vertigo.

Voice outcome measures after flexible endoscopic injection laryngoplasty

Objective To report voice outcome measures after injection laryngoplasty using the transnasal or transoral flexible endoscopic technique. Methods A retrospective review of all patients who underwent flexible endoscopic injection laryngoplasty between June 2010 and August 2016 was carried out. Only those patients who had pre- and post-injection voice outcome measures recorded were included. Voice outcome measures recorded included perceptual voice evaluation using GRBAS, Voice Handicap Index-10 (VHI-10), maximum phonation time (MPT) and closed quotient (CQ) before and after treatment. Results Forty-six patients were identified, of which 32 had pre- and post-injection voice outcome measures recorded. There were 19 males and 13 females. The mean age was 56.97 years (range 20–86 years) and the most common indication was unilateral vocal fold paralysis. Thirteen patients had a transnasal flexible endoscopic injection), while 19 patients were injected transorally. Following injection laryngoplasty, there was significant improvement in the mean grade of dysphonia (2.81 vs. 1.22, P < 0.01, roughness (2.44 vs. 1.34, P < 0.01), breathiness (2.72 vs. 1.13, P < 0.01), asthenia (2.78 vs. 1.06, P < 0.01), and strain (2.44 vs. 1.19, P < 0.01), MPT (3.85 s vs. 9.85 s, P < 0.01) and mean CQ (0.19 vs. 0.46, P < 0.01). There was also a decrease in the mean VHI-10 score (33.31 vs. 7.94, P < 0.01). Conclusion s: Patients achieved significant improvement in both subjective and objective voice measures after flexible endoscopic injection laryngoplasty via the nasal or transoral route. Voice outcomes were comparable to those reported for other approaches. This technique provides an alternative approach for the management of patients with vocal fold paralysis or glottal insufficiency.

Frame by Frame Analysis of Glottic Closure in Fasting Subjects

Objective : The purpose of the study is to examine vocal fold closure in fasting subjects using frame by frame analysis. Subjects and Methods : Twenty-two male subjects were recruited for this study. All subjects were evaluated while fasting and non fasting. Frame by frame analysis of at least three glottic cycles was performed and reported as a mean closed quotient. The degree of phonatory effort and vocal fatigue was also reported. Results : The mean closed quotient for all subjects while non fasting was 0.427 ± 0.098 and while fasting 0.441 ± 0.073, with no significant difference between the two (p value 0.417). There was a significant increase in the phonatory effort while fasting (0.23 non fasting vs. 0.77 fasting, p value 0.036). Conclusion: There is no change in the mean closed quotient in male subjects while fasting. However, most subjects exhibit a significant increase in

Association Between Facial Length and Width and Fundamental Frequency

OBJECTIVE This study aimed to evaluate the association between facial width and length and fundamental frequency (F0) and habitual frequency. STUDY DESIGN Prospective cross-sectional study. SUBJECTS A total of 50 subjects (35 females;15 males) were included in this study. METHODS Lateral and posteroanterior cephalometric measurements included: facial height (N-Me); widths of the maxilla (J-J), mandible (AG-AG), and face (Zyg-Zyg); ratios J-J to AG-AG, N-Me to Zyg-Zyg, and lower face to total face heights. All subjects underwent acoustic analysis using Visi-Pitch IV. Sample was stratified according to age and gender. RESULTS In the total group (mean age: 14.19±6.49 years; range 6-35 years), a significantly moderate negative correlation existed between Zyg-Zyg, J-J, and AG-AG, and F0 and habitual pitch. Similarly, N-Me moderately correlated with habitual pitch. In males, there was a significant moderate negative correlation between Zyg-Zyg and J-J, and habitual pitch, and between J-J and F0 (-0.571;p=0.026). In females, a significant moderate correlation existed between Zyg-Zyg and AG-AG, and habitual pitch, and between AG-AG and F0 (-0.347;p=0.041). In the prepubertal group (n=25), a negative moderate correlation occurred between J-J and AG-AG, N-Me and habitual frequency, and between J-J and F0 (-0.407;p=0.043). In the postpubertal group, there was a significant moderate correlation only between AG-AG and F0 (-0.403;p=0.046). CONCLUSION Facial length correlates significantly with habitual frequency, and facial width correlates significantly with both F0 and habitual pitch. A larger sample of adult subjects is needed to substantiate this conclusion.