Gerald E. Gutowski

BIOCHEMISTRY AND BIOLOGICAL EFFECTS OF THE PYRAZOFURINS* (PYRAZOMYCINS): INITIAL CLINICAL TRIAL

Pyrazofurin* (PF)’*2 is one of three biologically active C-nucleosides isolated from the broth filtrates of a strain of Streptomyces candidus. Along with PF, this culture produces lesser amounts of its C1,-a-anomer, Pyrazofurin B (PFB),3*4 and a third factor, tentatively identified as OxazinomycinS (Minimycin).6 Among these and the four other naturally occurring C-nucleosides, PF alone enjoys the distinction of possessing pharmacological activity that warrants its consideration as a clinical candidate.

Pyrazomycin B: Isolation and characterization of an α-C-nucleoside antibiotic related to pyrazomycin

Abstract This communication reports the isolation and structure of pyrazomycin B, the α-anomer of the anti-tumor and anti-viral antibiotic pyrazomycin. Spectral, chemical and x-ray crystallographic evidence is provided.

Carbon-13 nuclear magnetic resonance spectral analysis of C-nucleosides. The structure of pyrazomycin B1

Abstract The 13C nmr spectra of three nucleosides and four C-nucleosides have been recorded and all carbon signals assigned. These data have been utilized for the determination of the structure and conformation of the antibiotic pyrazomycin B. Steric differences have been shown to be reflected in the chemical shift values.