Gerald E. Hanks

Linear regressive analysis using prostate-specific antigen doubling time for predicting tumor biology and clinical outcome in prostate cancer

Background. This study was undertaken to calculate the prostate‐specific antigen doubling time (PSA‐DT) of prostate cancers recurrent after external beam radiation therapy and to investigate if a correlation exists between the PSA‐DT and the clinical behavior of prostate cancer as a possible reflection of the tumor doubling time.

Localized carcinoma of the prostate (Stages T1B, T1C, T2, and T3). Review of management with external beam radiation therapy

Background. Optimal treatment for patients with localized carcinoma of the prostate is controversial. Radiation therapy is an established modality in the management of these patients, and several reports indicate the results are comparable to those achieved with radical prostatectomy. Recently effectiveness of therapy for carcinoma of the prostate is being evaluated in light of posttreatment prostate‐specific antigen (PSA) determinations.

Defining the optimal radiation dose with three-dimensional conformal radiation therapy for patients with nonmetastatic prostate carcinoma by using recursive partitioning techniques

The objective of this study was to determine the effect of dose and its interaction with known prognostic variables, including pretreatment prostate specific antigen (PSA), Gleason score (GS), and T classification, on patients with nonmetastatic prostate carcinoma treated with three‐dimensional conformal radiation therapy (3DCRT) alone using recursive partitioning analysis.

Evidence of increased failure in the treatment of prostate carcinoma patients who have perineural invasion treated with three‐dimensional conformal radiation therapy

The detection of perineural invasion (PNI) in the diagnostic transrectal biopsy of the prostate is associated with a 93% frequency of extracapsular disease extension in patients treated by prostatectomy for adenocarcinoma of the prostate. Extracapsular extension is associated with an inferior outcome compared with that of patients who have organ‐confined disease. This study examined the association of PNI and treatment failure in a consecutive series of patients treated with three‐dimensional conformal radiation therapy (3DCRT) alone.

Validation of a treatment policy for patients with prostate specific antigen failure after three‐dimensional conformal prostate radiation therapy

The objective of this report was to present an outcomes validation for the Fox Chase Cancer Center (FCCC) management policy for patients who demonstrate prostate specific antigen (PSA) failure after receiving three‐dimensional conformal radiation therapy (3DCRT).

A gleason score of 7 predicts a worse outcome for prostate carcinoma patients treated with radiotherapy

In most reported surgical series, prostate carcinoma patients with a Gleason score of 7 have had worse outcomes than those with other moderately differentiated cancers. Because of variations in reporting grade and grouping Gleason scores, radiation series have conflicting results.

Histopathologic review of prostate biopsies from patients referred to a comprehensive cancer center

Clinicians at the Fox Chase Cancer Center (FCCC) base prostate carcinoma treatment decisions regarding need to treat, field size, total dose, and adjuvant hormonal therapy on known prognostic factors including clinical stage, Gleason score (GS), perineural invasion (PNI), and pretreatment prostate specific antigen levels. The pathology of every patient is reviewed at FCCC to confirm a diagnosis of malignancy. The objective of this study was to define differences between pathologic reviews and their impact on treatment between outside institutions and FCCC.

Patterns of radiation treatment of elderly patients with prostate cancer

Background. The patterns of radiation care of elderly patients with prostate cancer treated with radiation therapy have not been described. As our population ages and screening increases the number of patients diagnosed, this becomes an important issue.

The challenge of treating node-positive prostate cancer. An approach to resolving the questions.

Background. Prostate cancer commonly presents with positive pelvic lymph nodes. The appropriate management of patients with prostate cancer is controversial and no satisfactory randomized trials have been conducted.

Modeling postradiation prostate specific antigen level kinetics

The goals of this study are twofold: 1) to describe the postradiation kinetics of nonrecurring prostate carcinoma based on prostate specific antigen (PSA) levels in men who remain biochemically free of disease; and 2) to determine predictors of all three components of the resulting piecewise exponential model based on pretreatment and treatment characteristics.