Gerald L. Larson

A regio- and stereoselective synthesis of (Z) enol methyldiphenylsilyl ethers

Abstract The thermal rearrangement of α-(methyldiphenylsilyl) ketones in an apolar solvent or in the absence of a solvent provides Z:E mixtures of the corresponding enol silyl ethers. This same rearrangement in acetonitrile, however, gives the Z isomer cleanly, thus providing a regio- and stereoselective entry into (Z) enol silyl ethers.

The Synthesis of Gliflozins

of the general approaches to the key steps in the synthesis of gliflozins, a class of glucose transporters, are discussed. In particular the glycosidation step for the introduction of the key aryl moiety onto the glucose and the reduction steps are presented. The synthesis of gliflozins