Geraldine Ruth Mcfarlane

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Featured researches published by Geraldine Ruth Mcfarlane.

Bioorganic & Medicinal Chemistry Letters | 2009

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.

David P. Rotella; Geraldine Ruth Mcfarlane; Alexander Alexei Greenfield; Cristina Grosanu; Albert J. Robichaud; Rajiah Aldrin Denny; Rolf W. Feenstra; Sara Núñez-García; Jan-Hendrik Reinders; Martina A.W. van der Neut; Andrew C. McCreary; Chris G. Kruse; Kelly Sullivan; Farhana Pruthi; Margaret Lai; Jean Zhang; Dianne Kowal; Tikva Carrick; Steven M. Grauer; Rachel Navarra; Radka Graf; Karen L. Marquis; Mark H. Pausch

A 5-fluoro-tetrahydrocarbazole serotonin reuptake inhibitor (SRI) building block was combined with a variety of linkers and dopamine D2 receptor ligands in an attempt to identify potent D2 partial agonist/SRI molecules for treatment of schizophrenia. This approach has the potential to treat a broader range of symptoms compared to existing therapies. Selected compounds in this series demonstrate high affinity for both targets and D2 partial agonism in cell-based and in vivo assays.

Journal of Medicinal Chemistry | 2004

Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization

Hassan M. Elokdah; Magid Abou-Gharbia; James K. Hennan; Geraldine Ruth Mcfarlane; Cheryl P. Mugford; Girija Krishnamurthy; David L. Crandall

Archive | 2002

Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Hassan Mahmound Elokdah; Geraldine Ruth Mcfarlane; David Zenan Li; Lee Dalton Jennings; David L. Crandall

Journal of Medicinal Chemistry | 2004

Design, synthesis, and biological evaluation of thio-containing compounds with serum HDL-cholesterol-elevating properties.

Hassan M. Elokdah; Theodore S. Sulkowski; Magid Abou-Gharbia; John A. Butera; Sie-Yearl Chai; Geraldine Ruth Mcfarlane; Mar-Lee McKean; John Babiak; Steven J. Adelman; Elaine Quinet

Journal of Medicinal Chemistry | 2000

Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones.

Adam M. Gilbert; Madelene Antane; Thomas M. Argentieri; John A. Butera; Gerardo D. Francisco; Chris Freeden; Eric G. Gundersen; Russell Graceffa; David R. Herbst; Bradford H. Hirth; Joseph R. Lennox; Geraldine Ruth Mcfarlane; N. Wesley Norton; Dominick Anthony Quagliato; Jeffrey H. Sheldon; Dawn Warga; and Alexandra Wojdan; Morgan Woods

Archive | 2003