Geraldo Magela Magalhães

Clinical and immunohistochemical assessment of the effect of cyclosporin in keratinocytes and dermal dendrocytes in psoriasis.

Background:  Cyclosporine is a potent immunosupressor, which induces cytokeratin expression pattern changes and dermal dendrocytes number increase.

Mycetoma caused by Nocardia caviae in the first Brazilian patient

Background Mycetoma is a chronic subcutaneous mycosis caused by exogenous fungi or actinomycetes. This infection has a progressive course and shows a typical clinical characteristic of tumefaction, draining sinuses, and grains. Infection initiation is related to local trauma and can spread to muscle, underlying bone, and adjacent organs. Nocardia brasiliensis is the most frequent actinomycete isolated, while N. caviae is a rare agent.

Terapia fotodinâmica para tratamento de múltiplas lesões no couro cabeludo na síndrome do nevobasocelular - Relato de caso

Photodynamic therapy is an effective alternative for the treatment of non-melanoma skin cancer, selectively destroying the neoplastic cells through the use of photosensitizer substances that are irradiated with a source of light of adequate wave length. Nevoid Basal Cell Carcinoma Syndrome is a genodermatosis characterized by multiples basal cell carcinomas occurring at an early age, compelling patients to various surgeries, some of them disfiguring. The aim of this article is to show the excellent result of the treatment of multiple basal cell carcinomas on the scalp of a patient suffering from Nevoid Basal Cell Carcinoma Syndrome.

Subsídios para o estudo histopatológico das lesões ungueais

BACKGROUND: In this paper a broad review of nail biopsy is presented, emphasizing its anatomy, embryology, histology and histopathology. The indication and purpose of nail biopsy as well as the techniques available are reviewed in detail. OBJECTIVE: Define the appropriate site for nail biopsy according to nail disorder, compare two different methods of nail specimen softening: soaking in 20% potassium hydroxide and in 10% aqueous solution of Tween 40 and establish a routine for the nail biopsy procedure. METHODS: Our group studied eleven patients with nail disease who presented at the Dermatology Department in Pedro Ernesto University Hospital for a definite diagnosis. Twelve biopsies were performed. RESULTS: There were no differences in the softness achieved with the two methods and none harmed the cytologic and histologic analysis. CONCLUSIONS: The authors concluded that nail biopsy is a safe and useful procedure for nail diseases when clinical and laboratory methods fail to reach a diagnosis. A complete and thorough understanding of the nail unit anatomy is necessary to perform the procedure

Ação da pentoxifilina nos dendrócitos dérmicos FXIIIa de placas de psoríase

FUNDAMENTOS: Nao ha consenso sobre o papel dos dendrocitos dermicos (DD) nos eventos fisiopatologicos nos periodos de exacerbacao e de acalmia da doenca. A pentoxifilina (PTX) e uma metilxantina que inibe varios mecanismos inflamatorios. OBJETIVO: Estudar os efeitos da PTX sobre os dendroticos dermicos de placas de psoriase com tecnicas imuno-histoquimicas. MATERIAL E METODOS: Trinta biopsias de placas de psoriase antes e apos oito semanas de uso oral diario de 1.200mg de PTX foram incubadas com anticorpo primario de coelho antiFator XIIIa e anticorpo de ligacao conjugado com fosfatase alcalina. RESULTADOS: As celulas imunomarcadas Fator XIIIa+ foram proeminentes com morfologia dendritica arborescente na derme papilar formando linha celular logo abaixo da epiderme e exibindo arranjo nodular ao redor dos vasos. Apos tratamento, as celulas apresentaram-se com morfologia dendritica e fusiforme, distribuidas ao redor dos vasos da derme papilar e predominantemente fusiformes dispostas paralelamente a juncao dermoepidermica retificada. CONCLUSOES: A PTX promove aumento do fluxo sanguineo e diminuicao da adesividade endotelial, com aumento dos mastocitos e DD FXIIIa. A PTX inibe o TNF-alfa, que implica a diminuicao da expressao de receptores pelos DDs, como CCR7 e a manutencao do estimulo tecidual para sinalizacao e migracao dos precursores, uma vez que os processos etiopatogeneticos nao sao afetados pela droga.